377734-27-5

Basic information

• Product Name: Methyl 3-BroMo-5-forMylbenzoate
• Synonyms: Methyl 3-BroMo-5-forMylbenzoate;3-Bromo-5-formyl-benzoic acid methyl ester
• CAS NO: 377734-27-5
• Molecular Formula: C₉H₇BrO₃
• Molecular Weight: 243.05408
• Mol File: 377734-27-5.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 322.4±27.0 °C(Predicted)
• Appearance: /
• Density: 1.566±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: Methyl 3-BroMo-5-forMylbenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 3-BroMo-5-forMylbenzoate(377734-27-5)
• EPA Substance Registry System: Methyl 3-BroMo-5-forMylbenzoate(377734-27-5)

Safety Data

• Hazardous Substances Data: 377734-27-5(Hazardous Substances Data)

Usage

General Description

Methyl 3-Bromo-5-formylbenzoate is a specialized, organic compound that falls into the category of chemical intermediates, specifically, benzoic acid and derivatives. As its name suggests, it consists of a methyl group, a bromine atom, and a formyl group attached to a benzoate foundation. It is generally used in the scientific research and manufacturing processes as it can be a useful building block in organic synthesis. Notably, though, its specific properties such as toxicity, melting point, boiling point, and density may vary because it is usually customized to meet specific needs. Therefore, proper expertise and care is required in its handling and use.

Upstream product

• 51760-21-5 dimethyl 5-bromoisophthalate 
• 67-56-1 methanol 
• 398119-27-2 3-bromo-5-formylbenzoic acid 
• 619-21-6 m-formylphenyl benzoic acid 
• 52178-50-4 Methyl 3-formylbenzoate 

Downstream Products

• 1186519-21-0 methyl 3-bromo-5-(hydroxy(thiazol-2-yl)methyl)benzoate 
• 1186520-08-0 methyl 3-bromo-5-((dimethylamino)methyl)benzoate 
• 1186519-96-9 methyl 3-bromo-5-vinylbenzoate 
• 1186519-94-7 methyl 3-bromo-5-(2,2,2-trifluoro-1-hydroxyethyl)benzoate 
• 1186519-34-5 methyl 3-bromo-5-(oxiran-2-yl)benzoate 
• 1186519-97-0 methyl 3-bromo-5-(1,2-dihydroxyethyl)benzoate 
• 1186519-35-6 methyl 3-bromo-5-(1-(diethylamino)-2-hydroxyethyl)benzoate 
• 1186519-92-5 methyl 5-(hydroxy(thiazol-2-yl)methyl)-4'-methylbiphenyl-3-carboxylate 
• 1186519-22-1 5-(hydroxy(thiazol-2-yl)methyl)-4'-methylbiphenyl-3-carboxylic acid 
• 1186519-36-7 methyl 3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoate 
• 1186520-10-4 3-(2-(diethylamino)-2-hydroxyethyl)-5-(5-methylpyridin-2-yl)benzoic acid 
• 1186517-31-6 5-(hydroxy(thiazol-2-yl)methyl)-4'-methyl-N-((R)-1-(6-methylpyridin-3-yl)ethyl)biphenyl-3-carboxamide 
• 1186517-97-4 3-(2-(diethylamino)-1-hydroxyethyl)-5-(5-methylpyridin-2-yl)-N-((R)-1-(6-methylpyridin-3-yl)ethyl)benzamide 
• 161796-10-7 3-bromo-5-(methoxycarbonyl)benzoic acid 

Relevant articles and documents

NOVEL HETEROARYL-TRIAZOLE COMPOUNDS AS PESTICIDES

The present invention relates to novel heteroaryl-triazole and heteroaryl-tetrazole compounds of the general formula (I), in which the structural elements R1, R2, R3, R4 and R5 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

Exploration of Alternative Scaffolds for P2Y14Receptor Antagonists Containing a Biaryl Core

Various heteroaryl and bicyclo-aliphatic analogues of zwitterionic biaryl P2Y14 receptor (P2Y14R) antagonists were synthesized, and affinity was measured in P2Y14R-expressing Chinese hamster ovary cells by flow cytometry. Given this series' low water solubility, various polyethylene glycol derivatives of the distally binding piperidin-4-yl moiety of moderate affinity were synthesized. Rotation of previously identified 1,2,3-triazole attached to the central m-benzoic acid core (25) provided moderate affinity but not indole and benzimidazole substitution of the aryl-triazole. The corresponding P2Y14R region is predicted by homology modeling as a deep, sterically limited hydrophobic pocket, with the outward pointing piperidine moiety being the most flexible. Bicyclic-substituted piperidine ring derivatives of naphthalene antagonist 1, e.g., quinuclidine 17 (MRS4608, IC50 ≈ 20 nM at hP2Y14R/mP2Y14R), or of triazole 2, preserved affinity. Potent antagonists 1, 7a, 17, and 23 (10 mg/kg) protected in an ovalbumin/Aspergillus mouse asthma model, and PEG conjugate 12 reduced chronic pain. Thus, we expanded P2Y14R antagonist structure-activity relationship, introducing diverse physical-chemical properties.

PHENYLETHYLPYRIDINE DERIVATIVES AS PDE4-INHIBITORS

The invention relates to novel compounds which are inhibitors of the phosphodiesterase 4 (PDE4) enzyme and muscarinic M3 receptor antagonists, methods of preparing such compounds, compositions containing them and therapeutic use thereof.