37794-19-7

Basic information

• Product Name: 6-Fluoro-2-methylindanone
• Synonyms: 6-FLUORO-2-METHYL-1-INDANONE;6-FLUORO-2-METHYLINDANONE;2-Methyl-6-fluoro-1-indanone;6-FLUORO-2-METHYL-2,3-DIHYDRO-1H-INDEN-1-ONE;2-METYL-6-FLUORO-1-INDANONE;6-Fluoro-2-methylindan-1-one;6-fluoro-2,3-dihydro-2-Methylinden-1-one;6-FLUORO-2-METHYL-2,3-DIHYDROINDEN-1-ONE
• CAS NO: 37794-19-7
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.18
• EINECS: 1308068-626-2
• Product Categories: PHARMACEUTICAL INTERMEDIATES
• Mol File: 37794-19-7.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 240.9 °C at 760 mmHg
• Flash Point: 95.2 °C
• Appearance: /
• Density: 1.179 g/cm₃
• Vapor Pressure: 0.037mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: 307.4mg/L at 25℃
• CAS DataBase Reference: 6-Fluoro-2-methylindanone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-2-methylindanone(37794-19-7)
• EPA Substance Registry System: 6-Fluoro-2-methylindanone(37794-19-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 37794-19-7(Hazardous Substances Data)

Usage

Description

6-Fluoro-2-methylindanone, with the molecular formula C10H9FO, is a yellow-to-brown solid chemical compound characterized by a molecular weight of 164.18 g/mol. It serves as a versatile intermediate in the synthesis of pharmaceuticals and agrochemicals, and as a building block in the production of organic compounds for research and development. Recognized for its potential biological activities, 6-Fluoro-2-methylindanone and its derivatives have been the subject of pharmacological studies. However, due to its potential hazardous effects, careful handling is advised.

Uses

Used in Pharmaceutical Industry:
6-Fluoro-2-methylindanone is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
6-Fluoro-2-methylindanone is utilized as an intermediate in the production of agrochemicals, playing a role in the creation of compounds that can enhance crop protection and yield.
Used in Research and Development:
6-Fluoro-2-methylindanone is employed as a building block in the synthesis of organic compounds for research purposes, facilitating the exploration of new chemical entities and their potential applications.
Used in Biological Activity Studies:
6-Fluoro-2-methylindanone and its derivatives are used in pharmacological research to study their potential biological activities, with the aim of discovering new therapeutic agents or understanding their mechanisms of action.

InChI:InChI=1/C10H9FO/c1-6-4-7-2-3-8(11)5-9(7)10(6)12/h2-3,5-6H,4H2,1H3

Upstream product

• 29417-80-9 Methyl-2-methyl-3-p-fluorphenylpropionat 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 22138-72-3 3-(4-fluorophenyl)-2-methylacrylic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 893620-41-2 2-allyl-5-fluorobenzaldehyde 
• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 22138-73-4 3-(4-fluorophenyl)-2-methylpropanoic acid 
• 497-19-8 sodium carbonate 
• 860456-47-9 (3-fluorophenyl)isopropenylketone 

Downstream Products

• 49627-27-2 5-fluoro-2-methyl-1-(4-methylsulfanylbenzylidene)-3-indenylacetic acid 
• 38194-50-2 Sulindac 
• 32004-66-3 5-fluoro-2-methyl-1H-indene-3-acetic acid 
• 49627-27-2 sulindac sulfide 
• 61812-45-1 sulindac sulfide 
• 1632470-63-3 C₂₃H₂₂FN 
• 1346513-16-3 (Z)-3-(5-fluoro-1-(4-isopropylbenzylidene)-2-methyl-1H-inden-3-yl)propanenitrile 
• 1346513-15-2 C₂₃H₂₃FO₂ 
• 1346513-33-4 C₂₁H₁₈FNO₃ 
• 1346513-31-2 C₂₀H₁₄FNO₂ 
• 1346513-29-8 C₂₀H₁₄F₄O₂ 
• 1346513-32-3 C₂₁H₂₀FNO₂ 
• 1346513-30-1 C₂₀H₁₄FNO₂ 
• 1346513-27-6 C₂₁H₁₉FO₃ 

Relevant articles and documents

Preparation method for indanone compound

The invention especially relates to a preparation method for an indanone compound, belonging to the field of organic synthesis. The preparation method for the indanone compounds comprises the following steps: 1) subjecting a compound as shown in a formula I and a compound as shown in a formula II to a condensation reaction so as to prepare a compound as shown in a formula III; 2) subjecting the compound as shown in the formula III to hydrolysis in the presence of alkali so as to prepare a compound as shown in a formula IV; and 3) carrying out acylation and ring closure on the compound as shownin the formula IV so as to prepare the as shown in a formula V. Compared with the prior art, the preparation method for the indanone compound in the invention has the advantages of low raw material cost, simple operation, low production of waste water, waste gas and industrial residues, high yield and the like, and is more suitable for industrial production; and compared with various traditionalpreparation methods for the indanone compound, the preparation method of the invention has obvious advantages and shows good industrialization prospects.

Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

RXRα represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXRα and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXRα (tRXRα) with the p85α regulatory subunit of phosphatidylinositol-3-OH kinase (PI3K). Here we report the synthesis, testing and SAR of a series of novel analogs of Sulindac as potential modulators for inhibiting tRXRα-dependent AKT activation. A new compound 30 was identified to have improved biological activity.

PROCESS FOR THE PREPARATION OF 6-FLUORO-2-METHYL-1-INDANONE

A process for the preparation of 6-fluoro-2-methyl-l-indanone which relates to a process of preferential cyclization of (3-fluorophenyl)-isopropenyl-ketone to obtain 6-fluoro-2-methyl- 1-indanone regioisomer with respect to 4-fluoro-2-methyl-l-indanone regioisomer, is described.