37794-19-7

Basic information

• Product Name: 6-Fluoro-2-methylindanone
• Synonyms: 6-FLUORO-2-METHYL-1-INDANONE;6-FLUORO-2-METHYLINDANONE;2-Methyl-6-fluoro-1-indanone;6-FLUORO-2-METHYL-2,3-DIHYDRO-1H-INDEN-1-ONE;2-METYL-6-FLUORO-1-INDANONE;6-Fluoro-2-methylindan-1-one;6-fluoro-2,3-dihydro-2-Methylinden-1-one;6-FLUORO-2-METHYL-2,3-DIHYDROINDEN-1-ONE
• CAS NO: 37794-19-7
• Molecular Formula: C₁₀H₉FO
• Molecular Weight: 164.18
• EINECS: 1308068-626-2
• Product Categories: PHARMACEUTICAL INTERMEDIATES
• Mol File: 37794-19-7.mol
• Article Data: 29

Chemical Properties

• Boiling Point: 240.9 °C at 760 mmHg
• Flash Point: 95.2 °C
• Appearance: /
• Density: 1.179 g/cm₃
• Vapor Pressure: 0.037mmHg at 25°C
• Refractive Index: 1.534
• Storage Temp.: Sealed in dry,Room Temperature
• Water Solubility: 307.4mg/L at 25℃
• CAS DataBase Reference: 6-Fluoro-2-methylindanone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Fluoro-2-methylindanone(37794-19-7)
• EPA Substance Registry System: 6-Fluoro-2-methylindanone(37794-19-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 37794-19-7(Hazardous Substances Data)

Usage

General Description

6-Fluoro-2-methylindanone is a chemical compound with the molecular formula C10H9FO. It is a yellow-to-brown solid with a molecular weight of 164.18 g/mol. 6-Fluoro-2-methylindanone is commonly used as an intermediate in the synthesis of various pharmaceuticals and agrochemicals. It is also used as a building block in the production of organic compounds for research and development purposes. 6-Fluoro-2-methylindanone is known to have potential biological activities, and its derivatives have been studied for their various pharmacological properties. However, it is important to handle this compound with caution, as it may have hazardous effects if not handled properly.

InChI:InChI=1/C10H9FO/c1-6-4-7-2-3-8(11)5-9(7)10(6)12/h2-3,5-6H,4H2,1H3

Upstream product

• 29417-80-9 Methyl-2-methyl-3-p-fluorphenylpropionat 
• 352-11-4 1-chloromethyl-4-fluorobenzene 
• 22138-72-3 3-(4-fluorophenyl)-2-methylacrylic acid 
• 459-57-4 4-fluorobenzaldehyde 
• 893620-41-2 2-allyl-5-fluorobenzaldehyde 
• 94569-84-3 2-bromo-5-fluorobenzaldehyde 
• 22138-73-4 3-(4-fluorophenyl)-2-methylpropanoic acid 
• 497-19-8 sodium carbonate 
• 860456-47-9 (3-fluorophenyl)isopropenylketone 

Downstream Products

• 1346513-25-4 C₂₅H₂₇FO₂ 
• 1346513-28-7 C₂₀H₁₄F₄O₂ 
• 1346513-26-5 C₂₃H₂₃FO₂ 
• 1346513-42-5 C₂₄H₁₈FNO₂ 
• 1346513-27-6 C₂₁H₁₉FO₃ 
• 1346513-30-1 C₂₀H₁₄FNO₂ 
• 1346513-32-3 C₂₁H₂₀FNO₂ 
• 1346513-29-8 C₂₀H₁₄F₄O₂ 

Relevant articles and documents

Preparation method for indanone compound

The invention especially relates to a preparation method for an indanone compound, belonging to the field of organic synthesis. The preparation method for the indanone compounds comprises the following steps: 1) subjecting a compound as shown in a formula I and a compound as shown in a formula II to a condensation reaction so as to prepare a compound as shown in a formula III; 2) subjecting the compound as shown in the formula III to hydrolysis in the presence of alkali so as to prepare a compound as shown in a formula IV; and 3) carrying out acylation and ring closure on the compound as shownin the formula IV so as to prepare the as shown in a formula V. Compared with the prior art, the preparation method for the indanone compound in the invention has the advantages of low raw material cost, simple operation, low production of waste water, waste gas and industrial residues, high yield and the like, and is more suitable for industrial production; and compared with various traditionalpreparation methods for the indanone compound, the preparation method of the invention has obvious advantages and shows good industrialization prospects.

Synthesis and SAR study of modulators inhibiting tRXRα-dependent AKT activation

RXRα represents an intriguing and unique target for pharmacologic interventions. We recently showed that Sulindac and a designed analog could bind to RXRα and modulate its biological activity, including inhibition of the interaction of an N-terminally truncated RXRα (tRXRα) with the p85α regulatory subunit of phosphatidylinositol-3-OH kinase (PI3K). Here we report the synthesis, testing and SAR of a series of novel analogs of Sulindac as potential modulators for inhibiting tRXRα-dependent AKT activation. A new compound 30 was identified to have improved biological activity.

PROCESS FOR THE PREPARATION OF 6-FLUORO-2-METHYL-1-INDANONE

A process for the preparation of 6-fluoro-2-methyl-l-indanone which relates to a process of preferential cyclization of (3-fluorophenyl)-isopropenyl-ketone to obtain 6-fluoro-2-methyl- 1-indanone regioisomer with respect to 4-fluoro-2-methyl-l-indanone regioisomer, is described.