37795-76-9Relevant academic research and scientific papers
O-amino aromatic amide derivative as well as preparation method and application thereof
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Paragraph 0041-0044; 0086-0090, (2021/08/14)
The invention discloses an o-amino aromatic amide derivative as well as a preparation method and application thereof. The o-amino aromatic amide derivative is a compound with a structural general formula I, II and III or a pharmaceutically acceptable salt
Discovery of new potent protein arginine methyltransferase 5 (PRMT5) inhibitors by assembly of key pharmacophores from known inhibitors
Zhu, Kongkai,Song, Jia-Li,Tao, Hong-Rui,Cheng, Zhi-Qiang,Jiang, Cheng-Shi,Zhang, Hua
supporting information, p. 3693 - 3699 (2018/10/24)
Protein arginine methyltransferase 5 (PRMT5) is an epigenetics related enzyme that has been validated as a promising therapeutic target for human cancer. Up to now, two small molecule PRMT5 inhibitors has been put into phase I clinical trial. In the prese
2,3 Dihydro 9H isoxazolo[3,2 b]quinazolin 9 ones and 3,4 dihydro (1,2) oxazino[3,2 b]quinazolin 10(2H) ones
Reisner,Ludwig,Simon,Dejneka,Sofia
, p. 766 - 770 (2007/10/09)
Two series of compounds, 2,3-dihydro-9H-isoxazolo [3,2-b] quinazolin-9-ones and 3,4-dihydro-(1,2)-oxazino-[3,2-b]quinazolin-10 (2H)-ones, were synthesized and evaluated for anti-inflammatory, antipyretic and analgesic activity. The isoxazolo compounds were generally more active than their oxazino homologs. Three compounds, i.e., 2,3-dihydro 9H isoxazolo [3,2-b]quinazolin-9-one (W-2429) and its 2- and 3-methyl congeners, were the most active of all compounds tested in this study. On the basis of the biological results herein reported, W-2429 is considerably more effective than acetylsalicylic acid in inhibiting carrageenan-induced edema and in reducing brewer's yeast-induced fever in rats. Also, it was found to be more potent than propoxyphene hydrochloride in the Randall-Selitto test for analgesic activity.
