1689-73-2Relevant articles and documents
Redox chemistry, spectroelectrochemistry and catalytic activity of novel synthesized phthalocyanines bearing four schiff bases on the periphery
Karaca, Hüseyin
, p. 39 - 45 (2016)
The synthesis and characterization of novel metallophthalocyanines (M?=?Zn, Co) carrying four schiff base on four peripheral positions were realized. These complexes have been characterized by a combination of FT-IR, 1H NMR, HRMS and UV–Vis spectroscopy t
Synthesis, characterization, and antiproliferative and apoptosis inducing effects of novel: S -triazine derivatives
Shanmugam, Mani,Narayanan, Kuppusamy,Hari Prasad, Kamatam,Karthikeyan, Dhanapalan,Chandrasekaran, Loganathan,Atchudan, Raji,Chidambaranathan
, p. 1698 - 1714 (2018)
In an attempt to design and synthesize a new class of antitumor agents, a mild and eco-friendly protocol for nucleophilic substitution using an s-triazine scaffold, via amine and Schiff base derivatives, has been developed. In order to obtain antitumor activity, all synthesized compounds were screened in vitro for their cytotoxicity against human fibrosarcoma tumor cells (HT-1080) and a cervical cancer cell line (HeLa), for their ability to inhibit the growth of cancer cells. The selected s-triazine analogs (5c, 5d, and 6c) have been preliminarily studied for their reactive oxygen species (ROS) properties, mitochondrial membrane potential (MMP) and apoptosis (AO/EtBr) activity against the HT-1080 cancer cell line. The in vitro anticancer activity analysis has revealed that the synthesized compounds have good/moderate inhibitory activity against the tested cell lines compared to the standard drug. The theoretical study results also provide evidence that the s-triazines scaffolds have been successfully identified as superior p53-MDM2 inhibitors through structure-based design.
Polyoxometalate catalyzed imine synthesis: Investigation of mechanistic pathways
Adhikary, Subhasis D.,Mandal, Debaprasad
supporting information, (2020/05/25)
The syntheses of imines by oxidative coupling of primary alcohols and amines were achieved by using 2 molpercent polyoxometalate (POM) Na12[WZn3(H2O)2(ZnW9O34)2] (Zn–WZn3) catalyst in the presence of t-BuOK and di-oxygen with excellent conversion (up to 100percent) and selectivity (up to 100percent). Non-noble metal-based POM catalyst in the presence of base represents a new reaction protocol for the selective synthesis of imine from both aromatic and aliphatic primary amines with functional group tolerance. Control experiment shows the formation of di-oxygen bind Zn–WZn3 activated species. The electron-density of POM is mostly situated on the surface oxygen atoms of W–O–W bonds which can engage the alcoholic OH group and helps for the imine selectivity in the second step of imine synthesis.
Synthesis of novel 8-hydroxyquinoline derivatives through mannich reaction and their biological evaluation as potential immunomodulatory agents
Faizi, Shaheen,Sarfaraz, Tahira,Sumbul, Saima,Jabeen, Almas,Halim, Sobia A.,Mesaik, Mohammad A.,Ul-Haq, Zaheer
, p. 531 - 543 (2020/06/22)
Background: In continuation of our work on Mannich reaction on 8-hydroxyquinoline, fifteen different combinations of aromatic aldehydes and aniline were subjected to Mannich reaction from which twelve products (eight Mannich bases, two imines and two intr
