37816-20-9

Basic information

• Product Name: 7-hydroxy-8-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one
• Synonyms: Astragalus Metabolite 6;4H-1-Benzopyran-4-one, 7-hydroxy-8-methoxy-3-(4-methoxyphenyl)-
• CAS NO: 37816-20-9
• Molecular Formula: C₁₇H₁₄O₅
• Molecular Weight: 298.2901
• Mol File: 37816-20-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 517.4°C at 760 mmHg
• Flash Point: 194.2°C
• Density: 1.321g/cm³
• Vapor Pressure: 2.51E-11mmHg at 25°C
• Refractive Index: 1.621
• CAS DataBase Reference: 7-hydroxy-8-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 7-hydroxy-8-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one(37816-20-9)
• EPA Substance Registry System: 7-hydroxy-8-methoxy-3-(4-methoxyphenyl)-4H-chromen-4-one(37816-20-9)

Safety Data

• Hazardous Substances Data: 37816-20-9(Hazardous Substances Data)

Upstream product

• 124-41-4 sodium methylate 
• 485-72-3 7-Hydroxy-3-(4-methoxy-phenyl)-chromen-4-on 

Downstream Products

• 75187-63-2 8-hydroxydaidzein 
• 38412-64-5 7-acetoxy-8,4'-dimethoxyisoflavone 

Relevant articles and documents

Synthetic method of polyhydroxy isoflavone

The invention discloses a synthetic method of polyhydroxy isoflavone. The method comprises the following steps: (1) enabling formononetin to react with N-bromosuccinimide serving as a bromination reagent, and replacing one or more hydrogen atoms on a formononetin carbon ring with bromine atoms by controlling a molar ratio of formononetin to N-bromosuccinimide and controlling a reaction temperatureso as to obtain corresponding bromide; (2) enabling the bromide in the step (1) to react with sodium methoxide under the action of cuprous salt so as to allow bromine atoms on a carbon ring of the bromide to be substituted by a methoxy group, thereby obtaining a methoxylation product; and (3) subjecting the methoxylation product obtained in the step (2) to a demethylation reaction under the action of aluminum trichloride and dimethyl sulfide so as to obtain the polyhydroxy isoflavone. Compared with the prior art, the method of the invention has the advantages of rich sources of initial raw materials, mild reaction conditions, short steps, high yield and easiness in industrial production. The purity of the produced polyhydroxy isoflavone is greater than 99.0%, and the polyhydroxy isoflavone can be used for pharmacological activity research.