378185-88-7

Basic information

• Product Name: Silane, (1,1-dimethylethyl)(4-iodo-3,5-dimethylphenoxy)dimethyl-
• CAS NO: 378185-88-7
• Molecular Formula: C14H23IOSi
• Molecular Weight: 362.326
• Mol File: 378185-88-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Silane, (1,1-dimethylethyl)(4-iodo-3,5-dimethylphenoxy)dimethyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Silane, (1,1-dimethylethyl)(4-iodo-3,5-dimethylphenoxy)dimethyl-(378185-88-7)
• EPA Substance Registry System: Silane, (1,1-dimethylethyl)(4-iodo-3,5-dimethylphenoxy)dimethyl-(378185-88-7)

Safety Data

• Hazardous Substances Data: 378185-88-7(Hazardous Substances Data)

Upstream product

• 80826-86-4 4-iodo-3,5-dimethylphenol 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 108-68-9 3,5-Dimethylphenol 

Downstream Products

• 58537-99-8 4-hydroxy-2,6-dimethylbenzonitrile 
• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 28924-92-7 4-(benzyloxy)-2,6-dimethylbenzaldehyde 
• 95741-45-0 4-(benzyloxy)-2,6-dimethylbenzoic acid 
• 75056-97-2 2,6-dimethyl-4-hydroxybenzoic acid 
• 378185-93-4 (2R)-1-[(4R)-4-Benzyl-2-oxo-1,3-oxazolan-3-yl]-2-cyclohexyl-3-(4-tert-butyldimethylsilyloxy-2,6-dimethylphenyl)propan-1-one 
• 378185-97-8 (2R)-1-[(4R)-4-Benzyl-2-oxo-1,3-oxazolan-3-yl]-3-(4-tert-butyldimethylsilyloxy-2,6-dimethylphenyl)-2-phenylpropan-1-one 
• 378185-91-2 4-(Bromomethyl)-3,5-dimethyl-tert-butyldimethylsilyloxyphenol 
• 378185-90-1 (4-tert-Butyldimethylsilyloxy-2,6-dimethylphenyl)methanol 
• 378185-89-8 4-(tert-butyldimethylsilanyloxy)-2,6-dimethylbenzaldehyde 

Relevant articles and documents

New Acyloxymethyl Ketones: Useful Probes for Cysteine Protease Profiling

Peptidyl-acyloxymethyl ketones (AOMKs) belong to a class of selective, irreversible inhibitors (activity-based probes) widely used as chemical tools of investigating proteins, for example, in activity-based protein profiling. The synthesis of the AOMKs has always been challenging and current methodologies involve both solution and solid-phase synthesis. Herein, the synthesis of a new scaffold useful for the preparation of peptidyl-AOMKs is reported and it is demonstrated that the new synthetic probes bearing a 4-functionalized 2,6-dimethylbenzoate efficiently inhibit cysteine proteases like cathepsin B.