378185-89-8

Upstream product

• 68-12-2 N,N-dimethyl-formamide 
• 378185-88-7 tert-butyl(4-iodo-3,5-dimethylphenoxy)dimethylsilane 
• 149228-92-2 (4-bromo-3,5-dimethylphenoxy)(tert-butyl)-di-methylsilane 
• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 7463-51-6 4-bromo-3,5-dimethylphenol 
• 108-68-9 3,5-Dimethylphenol 
• 80826-86-4 4-iodo-3,5-dimethylphenol 

Downstream Products

• 70547-87-4 2,6-dimethyl-4-hydroxybenzaldehyde 
• 75056-97-2 2,6-dimethyl-4-hydroxybenzoic acid 
• 95741-45-0 4-(benzyloxy)-2,6-dimethylbenzoic acid 
• 28924-92-7 4-(benzyloxy)-2,6-dimethylbenzaldehyde 
• 1021166-08-4 4-formyl-3,5-dimethylphenyl trifluoromethanesulfonate 
• 378185-90-1 (4-tert-Butyldimethylsilyloxy-2,6-dimethylphenyl)methanol 
• 378185-93-4 (2R)-1-[(4R)-4-Benzyl-2-oxo-1,3-oxazolan-3-yl]-2-cyclohexyl-3-(4-tert-butyldimethylsilyloxy-2,6-dimethylphenyl)propan-1-one 
• 378185-97-8 (2R)-1-[(4R)-4-Benzyl-2-oxo-1,3-oxazolan-3-yl]-3-(4-tert-butyldimethylsilyloxy-2,6-dimethylphenyl)-2-phenylpropan-1-one 
• 378185-91-2 4-(Bromomethyl)-3,5-dimethyl-tert-butyldimethylsilyloxyphenol 

Relevant academic research and scientific papers

NOVEL COMPOUNDS AND THEIR USES AS THYROID HORMONE RECEPTOR AGONISTS

A compound of formula (I) or (Ia), or a tautomer or a pharmaceutically acceptable salt thereof is provided. Compounds of formula (II) to (V), or a tautomer or a pharmaceutically acceptable salt thereof are also provided. These compounds and the pharmaceutical compositions containing them are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto． (I), (Ia)

New Acyloxymethyl Ketones: Useful Probes for Cysteine Protease Profiling

Peptidyl-acyloxymethyl ketones (AOMKs) belong to a class of selective, irreversible inhibitors (activity-based probes) widely used as chemical tools of investigating proteins, for example, in activity-based protein profiling. The synthesis of the AOMKs has always been challenging and current methodologies involve both solution and solid-phase synthesis. Herein, the synthesis of a new scaffold useful for the preparation of peptidyl-AOMKs is reported and it is demonstrated that the new synthetic probes bearing a 4-functionalized 2,6-dimethylbenzoate efficiently inhibit cysteine proteases like cathepsin B.

Enantioselective Construction of Functionalized Tetrahydrocarbazoles Enabled by Asymmetric Relay Catalysis of Gold Complex and Chiral Br?nsted Acid

An intramolecular hydroamination/Michael addition cascade is realized using a combination of gold(I) complex and chiral BINOL-phosphoric acid, affording fused-tetrahydrocarbazole scaffolds in excellent yields and high enantioselectivities.

Stereospecific syntheses of 2-alkyl and 2-phenyl substituted 3-(2,6-dimethyl-4-hydroxyphenyl)propanoic acids

Stereospecific syntheses of 2-methyl-, 2-ethyl-, 2-cyclohexyland 2-phenyl- substituted 3-(2,6-dimethyl-4-hydroxyphenyl)propanoic acids were developed. The key steps for the formation of the stereogenic centers involved the utilization of Evans' 4-benzyl-2-oxazolidinone chiral auxiliary. These compounds were designed to replace the N-terminal tyrosine residue in opioid peptides.