37819-89-9

Upstream product

• 36768-62-4 4-AMINO-2,2,6,6-TETRAMETHYLPIPERIDINE 
• 98-88-4 benzoyl chloride 
• 113230-84-5 N-(1-oxo-2,2,6,6-tetramethylpiperidin-4-yl)-benzoylamide 
• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 14691-88-4 4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl 

Downstream Products

• 63206-88-2 4-benzoylamino-2,2,6,6-tetramethyl-piperidine-1-carbonitrile 
• 113230-84-5 N-(1-oxo-2,2,6,6-tetramethylpiperidin-4-yl)-benzoylamide 

Relevant academic research and scientific papers

Based on metal catalyzed coupling reaction of formaldehyde in food detection method and kit therefor (by machine translation)

The invention provides a method and a kit for detecting formaldehyde in food based on metal catalysis coupling reaction. The metal catalysis coupling reaction comprises that coupling reaction is carried out on formaldehyde, amine and alkyne in presence of

4-Amino-TEMPO as N-Nucleophile in Palladium-Catalyzed Aminocarbonylation

Palladium-catalyzed aminocarbonylation of iodobenzene and iodoalkenes (1-iodocyclohexene, 4-tert-butyl-1-iodocyclohexene, α-iodostyrene, 17-iodoandrost-16-ene) was carried out using a free radical (4-amino-TEMPO) for the first time. Its reduced form (4-amino-2,2,6,6-tetramethylpiperidine) was also used as N-nucleophile. The free radical was partially reduced under aminocarbonylation conditions; however, the isolation of carbonylated products bearing a stable radical moiety was successfully accomplished. It was proved that the reduction of the 1-oxyl functionality took place to higher extent when more severe conditions (40 bar CO pressure) were used. The mixture of carboxamide and 2-ketocarboxamide products was obtained using iodobenzene because of single and double carbon monoxide insertion, respectively. In turn, carboxamide derivatives were formed exclusively when iodoalkenes were used as substrates.

Visual detection of formaldehyde by highly selective fluorophore labeling via gold(iii) complex-mediated three-component coupling reaction

A novel method for visual detection of formaldehyde with excellent selectivity via a gold(iii) complex-mediated three-component coupling reaction of resin-linked sterically bulky amines and fluorescent alkynes has been developed.

Visual detection of formaldehyde by highly selective fluorophore labeling via gold(III) complex-mediated three-component coupling reaction

A novel method for visual detection of formaldehyde with excellent selectivity via a gold(iii) complex-mediated three-component coupling reaction of resin-linked sterically bulky amines and fluorescent alkynes has been developed.

Photolabile protecting groups for nitroxide spin labels

Nitroxide spin labels can be protected against critical conditions of DNA/RNA or peptide synthesis by reduction and alkylation with light-sensitive groups such as nitrobenzyl- or aminocoumarins. High chemical stability qualifies tetraethylisoindoline 5 an

Anticonvulsant activity and interactions with neuronal voltage- dependent sodium channel of analogues of ameltolide

Fifteen compounds related to ameltolide (LY 201116) were studied for (i) anticonvulsant potential in the maximal electroshock-induced seizures (MES) and the subcutaneous pentylenetetrazol (sc Ptz)tests in mice and rats and (ii) interactions with neuronal voltage-dependent sodium channels. Compounds were chosen ranging in anticonvulsant activity in mice from very active to inactive. The active compounds were defined as those protecting 50% of the animals at doses between 10 and 50 μmol/kg and inactive compounds as those protecting 50% of the animals at doses greater than 1 mmol/kg. The series studied included three N-(2,6-dimethylphenyl)benzamides (compounds 1, 2 (ameltolide), and 3), three N-(2,2,6,6-tetramethyl)piperidinyl-4-benzamides (compounds 4, 5, 6), one phenylthiourea (compound 7), five N-(2,6- dimethylphenyl)phthalimides (compounds 8, 9, 10, 13, and 14), two N- phenylphthalimide derivatives (compounds 11 and 12), and one N-(2,2,6,6- tetramethyl)piperidinyl-4-phthalimide (compound 15). Phenytoin (PHT) was employed as the reference prototype antiepileptic drug. After inital screening in mice, compounds 1, 2, 3, 5, 8, 9, 10, 13, and 14 were selected for further testing in rats. Anticonvulsant ED50s (effective doses in at least 50% of animals tested) of compounds in the MES test were determined in rats dosed orally and amounted to 52 (1), 135 (2), 284 (3), 231 (8), 131 (9), 25 (10), 369 (13), 354 (14), and 121 (PHT) μmol/kg, compound 5 presenting with an ED50 value higher than 650 μmol/kg. In our hands, the apparent IC50s (inhibitory concentrations 50) of compounds toward binding to rat brain synaptosomes of [3H]batrachotoxinin-A-20α-benzoate were 0.25 (1), 0.97 (2), 0.35 .(3), 25.8 (5), 161.3 (8), 183.5 (9), 0.11 (10), 1.86 (13), 47.8 (14), and 0.86 (PHT) μM. The relationship between the activity in the MES test and the capacity to interact in vitro with neuronal voltage- dependent sodium channels and the fact that the IC50 values obtained in the in vitro test are close to the brain concentrations at which anticonvulsant activities are reported to occur for ameltolide strongly suggest that the anticonvulsant properties of most compounds tested could be a direct result of their interaction with the neuronal voltage-dependent sodium channel.