113230-84-5

Usage

Type of compound

chemical compound

Properties

+ Stable free radical
+ Used as a catalyst
+ Used as a spin labeling reagent
+ Has a nitroxide functional group
+ Useful in studying the behavior of radicals
+ Useful in studying the mechanisms of various chemical reactions
+ Used in the synthesis of various organic compounds
+ Used as a stabilizer in polymerization reactions
+ Potential antioxidant and anti-inflammatory properties
+ Promising candidate for pharmaceutical and biomedical applications.

Upstream product

• 591-50-4 iodobenzene 
• 201230-82-2 carbon monoxide 
• 14691-88-4 4-amino-2,2,6,6-tetramethyl-1-piperidine-1-oxyl 
• 1620751-81-6 N-(1-{[7-(diethylamino)-2-oxo-2H-chromen-4-yl]methoxy}-2,2,6,6-tetramethylpiperidin-4-yl)benzamide 
• 1620751-80-5 (±)-N-{1-[1-(4,5-dimethoxy-2-nitrophenyl)ethoxy]-2,2,6,6-tetramethylpiperidin-4-yl}benzamide 
• 1620751-79-2 (±)-N-{1-[1-(2-nitrophenyl)ethoxy]-2,2,6,6-tetramethylpiperidin-4-yl}benzamide 
• 37819-89-9 N-[2,2,6,6-tetramethyl-4-piperidinyl]benzamide 
• 98-88-4 benzoyl chloride 

Downstream Products

• 37819-89-9 N-[2,2,6,6-tetramethyl-4-piperidinyl]benzamide 
• 404852-90-0 C₁₆H₂₄N₂O₂ 
• 1620751-81-6 N-(1-{[7-(diethylamino)-2-oxo-2H-chromen-4-yl]methoxy}-2,2,6,6-tetramethylpiperidin-4-yl)benzamide 

Relevant academic research and scientific papers

4-Amino-TEMPO as N-Nucleophile in Palladium-Catalyzed Aminocarbonylation

Palladium-catalyzed aminocarbonylation of iodobenzene and iodoalkenes (1-iodocyclohexene, 4-tert-butyl-1-iodocyclohexene, α-iodostyrene, 17-iodoandrost-16-ene) was carried out using a free radical (4-amino-TEMPO) for the first time. Its reduced form (4-amino-2,2,6,6-tetramethylpiperidine) was also used as N-nucleophile. The free radical was partially reduced under aminocarbonylation conditions; however, the isolation of carbonylated products bearing a stable radical moiety was successfully accomplished. It was proved that the reduction of the 1-oxyl functionality took place to higher extent when more severe conditions (40 bar CO pressure) were used. The mixture of carboxamide and 2-ketocarboxamide products was obtained using iodobenzene because of single and double carbon monoxide insertion, respectively. In turn, carboxamide derivatives were formed exclusively when iodoalkenes were used as substrates.

Synthesis, physicochemical properties and antimicrobial activity of mono-/dinitroxyl amides

Two comparative sets of mono-/dinitroxyl amides were designed and prepared. The novel TEMPO and/or PROXYL derivatives were fully characterised and their spin, redox and antimicrobial properties were determined. Cyclic voltammetry revealed (quasi)reversibl

Photolabile protecting groups for nitroxide spin labels

Nitroxide spin labels can be protected against critical conditions of DNA/RNA or peptide synthesis by reduction and alkylation with light-sensitive groups such as nitrobenzyl- or aminocoumarins. High chemical stability qualifies tetraethylisoindoline 5 an