378748-06-2Relevant academic research and scientific papers
Second generation of TSAO compounds directed against HIV-1 TSAO-resistant strains
Lobaton,Velazquez,Perez-Perez,Jimeno,San-Felix,De Clereq,Balzarini,Camarasa
, p. 707 - 710 (2001)
A second generation of TSAO molecules directed against TSAO-resistant strains have been prepared. The presence of two neighboring carbonyl groups at the 4″ position of the 3′-spiro moiety seems to be important for the anti-HIV-1 activity against both wild type and TSAO-resistant strains. NMR conformational studies in solution and theoretical calculations of the novel compounds have also been carried out.
Novel non-nucleoside human cytomegalovirus inhibitors based upon TSAO nucleoside derivatives: Structure-activity relationships
De Castro, Sonia,Andrei, Graziela,Snoeck, Robert,Balzarini, Jan,Camarasa, Maria-Jose,Velazquez, Sonsoles
, p. 625 - 628 (2008/09/17)
TSAO derivatives are a unique group of potent and highly specific inhibitors of HIV-1 replication. We have recently reported 4′-ureido TSAO derivatives that are devoid of anti-HIV-1 activity, but inhibit human cytomegalovirus with an activity comparable t
Novel [2′,5′-Bis-O-(tert-butyldimethylsily)-β-D- ribofuranosyl]-3′-spiro-5″-(4″-amino-1″, 2″-oxathiole-2″,2″-diozide) derivatives with anti-HIV-1 and anti-human-cytomegalovirus activity
De Castro, Sonia,Lobatón, Esther,Pérez-Pérez, María-Jesús,San-Félix, Ana,Cordeiro, Alessandra,Andrei, Graciela,Snoeck, Robert,De Clercq, Erik,Balzarini, Jan,Camarasa, María-José,Velázquez, Sonsoles
, p. 1158 - 1168 (2007/10/03)
New [2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D- ribofuranosyl]-3′-spiro-5″-(4″-amino-1″, 2″-oxathiole-2″,2″-dioxide) (TSAO) derivatives substituted at the 4″-amino group of the spiro moiety with different carbonyl functionalities have been designed and sy
