378750-01-7

Upstream product

• 58479-61-1 tert-butylchlorodiphenylsilane 
• 378749-99-6 ethyl (E,5S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-hexenoate 
• 378750-00-6 (2E,5S)-5-[(tert-butyldiphenylsilyl)oxy]hex-2-en-1-ol 
• 364597-23-9 (3S)-3-{[tert-butyl(diphenyl)silyl]oxy}butanal 
• 215444-96-5 methyl (3S)-3-{[tert-butyl(diphenyl)silyl]oxy}butanoate 
• 328114-40-5 (2R,3R,5S)-5-(tert-butyldiphenylsilyl)-2,3-(oxiranyl)hexan-1-ol 

Downstream Products

• 378749-97-4 2-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxy)-6-[((1E,3E)-2-penta-1,3-dienyl)-[1,3]dithian-2-ylmethyl]-benzoic acid (R)-1-methyl-2-((2R,3R)-3-vinyl-oxiranyl)-ethyl ester 
• 378749-98-5 C₄₃H₅₆O₅S₂Si₂ 
• 378749-96-3 4-(tert-Butyl-diphenyl-silanyloxy)-2-hydroxy-6-[((1E,3E)-2-penta-1,3-dienyl)-[1,3]dithian-2-ylmethyl]-benzoic acid (R)-1-methyl-2-((2R,3R)-3-vinyl-oxiranyl)-ethyl ester 
• 378749-94-1 4-(tert-Butyl-diphenyl-silanyloxy)-2-chloromethyl-6-hydroxy-benzoic acid (R)-1-methyl-2-((2R,3R)-3-vinyl-oxiranyl)-ethyl ester 
• 12772-57-5 (9Z,11E)-(4R,6R,8R)-16-Chloro-17,19-dihydroxy-4-methyl-3,7-dioxa-tricyclo[13.4.0.0^6,8]nonadeca-1⁽¹⁵⁾,9,11,16,18-pentaene-2,13-dione 
• 75207-13-5 Monocillin I 
• 378750-02-8 (3R,4R,6S)-6-(tert-butyldiphenylsilyl)-3,4-(oxiranyl)hept-1-ene 

Relevant academic research and scientific papers

Concise asymmetric syntheses of radicicol and monocillin I

Radicicol (1) exhibits potent anticancer properties in vitro, which are likely to be mediated through its high affinity (20 nM) for the molecular chaperone Hsp90. Recently, we reported the results of a synthetic program targeting radicicol (1) and monocil