378749-98-5

Upstream product

• 166322-67-4 2-(chloromethyl)-4,6-dimethoxy-benzaldehyde 
• 378750-00-6 (2E,5S)-5-[(tert-butyldiphenylsilyl)oxy]hex-2-en-1-ol 
• 378749-99-6 ethyl (E,5S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-hexenoate 
• 378750-02-8 (3R,4R,6S)-6-(tert-butyldiphenylsilyl)-3,4-(oxiranyl)hept-1-ene 
• 378749-96-3 4-(tert-Butyl-diphenyl-silanyloxy)-2-hydroxy-6-[((1E,3E)-2-penta-1,3-dienyl)-[1,3]dithian-2-ylmethyl]-benzoic acid (R)-1-methyl-2-((2R,3R)-3-vinyl-oxiranyl)-ethyl ester 
• 378749-91-8 2-(chloromethyl)-4,6-dihydroxybenzaldehyde 
• 378749-88-3 (3R,4R,6S)-6-(hydroxy)-3,4-(oxiranyl)hept-1-ene 
• 145546-15-2 (E,E)-2-(1,3-pentadien-1-yl)-1,3-dithiane 
• 705-76-0 3,5-dimethoxybenzyl alcohol 
• 142-83-6 trans,trans-2,4-Hexadienal 
• 328114-40-5 (2R,3R,5S)-5-(tert-butyldiphenylsilyl)-2,3-(oxiranyl)hexan-1-ol 
• 378750-01-7 (2R,3R,5S)-5-(tert-butyldiphenylsilyl)-2,3-(oxiranyl)hexan-1-al 
• 378749-97-4 2-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxy)-6-[((1E,3E)-2-penta-1,3-dienyl)-[1,3]dithian-2-ylmethyl]-benzoic acid (R)-1-methyl-2-((2R,3R)-3-vinyl-oxiranyl)-ethyl ester 
• 378749-94-1 4-(tert-Butyl-diphenyl-silanyloxy)-2-chloromethyl-6-hydroxy-benzoic acid (R)-1-methyl-2-((2R,3R)-3-vinyl-oxiranyl)-ethyl ester 

Downstream Products

• 12772-57-5 (9Z,11E)-(4R,6R,8R)-16-Chloro-17,19-dihydroxy-4-methyl-3,7-dioxa-tricyclo[13.4.0.0^6,8]nonadeca-1⁽¹⁵⁾,9,11,16,18-pentaene-2,13-dione 
• 75207-13-5 Monocillin I 

Relevant academic research and scientific papers

Effects of temperature and concentration in some ring closing metathesis reactions

Ring closing metathesis (RCM) has emerged as a powerful tool to construct macrocyclic ring systems. However, the product distribution of monomer and oligomers is often a problem in the formation of medium to large rings. In the course of synthetic studies on the natural product radicicol and its analogs, we have found that the reaction temperature, along with concentration, has significant impact on the outcome of the product ratio. Specifically, carrying out the RCM reaction in refluxing toluene (110°C) at higher dilution affords improved yields of the monomeric macrocycle. Similar observations for another family of macrolactone natural products, the epothilones, are also reported.

Concise asymmetric syntheses of radicicol and monocillin I

Radicicol (1) exhibits potent anticancer properties in vitro, which are likely to be mediated through its high affinity (20 nM) for the molecular chaperone Hsp90. Recently, we reported the results of a synthetic program targeting radicicol (1) and monocil