328114-40-5

Upstream product

• 378750-00-6 (2E,5S)-5-[(tert-butyldiphenylsilyl)oxy]hex-2-en-1-ol 
• 754201-28-0 (S)-tert-butyl (pent-4-en-2-yloxy)diphenylsilane 
• 378749-99-6 ethyl (E,5S)-5-{[tert-butyl(diphenyl)silyl]oxy}-2-hexenoate 
• 364597-23-9 (3S)-3-{[tert-butyl(diphenyl)silyl]oxy}butanal 
• 215444-96-5 methyl (3S)-3-{[tert-butyl(diphenyl)silyl]oxy}butanoate 
• 58479-61-1 tert-butylchlorodiphenylsilane 

Downstream Products

• 378750-01-7 (2R,3R,5S)-5-(tert-butyldiphenylsilyl)-2,3-(oxiranyl)hexan-1-al 
• 378750-02-8 (3R,4R,6S)-6-(tert-butyldiphenylsilyl)-3,4-(oxiranyl)hept-1-ene 
• 378749-97-4 2-(tert-Butyl-dimethyl-silanyloxy)-4-(tert-butyl-diphenyl-silanyloxy)-6-[((1E,3E)-2-penta-1,3-dienyl)-[1,3]dithian-2-ylmethyl]-benzoic acid (R)-1-methyl-2-((2R,3R)-3-vinyl-oxiranyl)-ethyl ester 
• 378749-98-5 C₄₃H₅₆O₅S₂Si₂ 
• 378749-96-3 4-(tert-Butyl-diphenyl-silanyloxy)-2-hydroxy-6-[((1E,3E)-2-penta-1,3-dienyl)-[1,3]dithian-2-ylmethyl]-benzoic acid (R)-1-methyl-2-((2R,3R)-3-vinyl-oxiranyl)-ethyl ester 
• 378749-94-1 4-(tert-Butyl-diphenyl-silanyloxy)-2-chloromethyl-6-hydroxy-benzoic acid (R)-1-methyl-2-((2R,3R)-3-vinyl-oxiranyl)-ethyl ester 
• 12772-57-5 (9Z,11E)-(4R,6R,8R)-16-Chloro-17,19-dihydroxy-4-methyl-3,7-dioxa-tricyclo[13.4.0.0^6,8]nonadeca-1⁽¹⁵⁾,9,11,16,18-pentaene-2,13-dione 
• 75207-13-5 Monocillin I 

Relevant academic research and scientific papers

Synthesis of (3R,5S)-5-hydroxy-de-O-methyllasiodiplodin: A facile and stereoselective approach

A concise and facile synthesis of (3R,5S)-5-hydroxy-de-O-methyllasiodiplodin has been demonstrated in 12 steps starting from methylacetoacetate and (±)propylene oxide. The key reactions involved are Jacobsen's hydrolytic kinetic resolution, Sharpless asymmetric epoxidation, Mitsunobu, and ring closing metathesis reaction for the construction of macrolactone with two chiral substitutions on it.

Concise asymmetric syntheses of radicicol and monocillin I

Radicicol (1) exhibits potent anticancer properties in vitro, which are likely to be mediated through its high affinity (20 nM) for the molecular chaperone Hsp90. Recently, we reported the results of a synthetic program targeting radicicol (1) and monocil