37906-15-3Relevant academic research and scientific papers
Pd-Catalyzed Csp2-H Functionalization of Heteroarenes via Isocyanide Insertion: Concise Synthesis of Di-(Hetero)Aryl Ketones and Di-(Hetero)Aryl Alkylamines
Sharma, Upendra K.,Sharma, Nandini,Xu, Jun,Song, Gonghua,Van Der Eycken, Erik V.
supporting information, p. 4908 - 4912 (2015/03/30)
We report herein an efficient Pd-catalyzed direct C-H bond functionalization of heteroarenes via an isocyanide insertion strategy for the synthesis of di-(hetero)aryl ketones and di-(hetero)aryl alkylamines. The methodology involves a three component reaction between an azole, a haloarene and an isocyanide resulting in the formation of an imine, which in turn is either hydrolyzed or reduced to get the desired product.
A novel one-pot synthesis of α-keto-1,3,4-oxadiazole derivatives based on isocyanide-Nef reaction
Cui, Liren,Liu, Qiong,Yu, Jingxun,Ni, Chongzhi,Yu, Hui
experimental part, p. 5530 - 5533 (2011/11/05)
Various α-keto-1,3,4-oxadiazole derivatives were synthesized through a sequential intermolecular dehydrochlorination/intramolecular aza-Wittig reaction of carboxylic acids and imidoyl chloride intermediates, which were generated by isocyanide-Nef reaction
