37950-87-1

Basic information

• Product Name: 4-Fluoro-N-Methyl-N-phenylbenzaMide, 97%
• Synonyms: 4-Fluoro-N-Methyl-N-phenylbenzaMide, 97%
• CAS NO: 37950-87-1
• Molecular Formula: C₁₄H₁₂FNO
• Molecular Weight: 229.2495832
• Mol File: 37950-87-1.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-Fluoro-N-Methyl-N-phenylbenzaMide, 97%(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoro-N-Methyl-N-phenylbenzaMide, 97%(37950-87-1)
• EPA Substance Registry System: 4-Fluoro-N-Methyl-N-phenylbenzaMide, 97%(37950-87-1)

Safety Data

• Hazardous Substances Data: 37950-87-1(Hazardous Substances Data)

Upstream product

• 403-43-0 4-fluorobenzoyl chloride 
• 459-57-4 4-fluorobenzaldehyde 
• 100-61-8 N-methylaniline 
• 451-46-7 4-fluorobenzoic acid ethyl ester 
• 35954-01-9 lithium N-methylanilide 
• 403-33-8 methyl 4-flurobenzoate 
• 352-34-1 4-fluoro-1-iodobenzene 
• 201230-82-2 carbon monoxide 
• 121-69-7 N,N-dimethyl-aniline 

Downstream Products

• 366-63-2 4-fluoro-N-phenylbenzamide 
• 459-57-4 4-fluorobenzaldehyde 
• 16547-13-0 4-fluoro-N-methyl-N-phenylbenzylamine 
• 403-33-8 methyl 4-flurobenzoate 

Relevant articles and documents

Nickel-Catalyzed Oxidative Transamidation of Tertiary Aromatic Amines with N -Acylsaccharins

The use of tertiary amines as surrogates for secondary amines has prominent advantages in terms of stabilization and ease of handling. A Ni-catalyzed transamidation of N -acylsaccharins with tertiary aromatic amines is reported. By using tert -butyl hydroperoxide as the terminal oxidant, this reaction permits selective cleavage of the C(sp 3)-N bonds of unsymmetrical tertiary aromatic amines depending on the sizes of the alkyl substituents.

Ultrafast amidation of esters using lithium amides under aerobic ambient temperature conditions in sustainable solvents

Lithium amides constitute one of the most commonly used classes of reagents in synthetic chemistry. However, despite having many applications, their use is handicapped by the requirement of low temperatures, in order to control their reactivity, as well as the need for dry organic solvents and protective inert atmosphere protocols to prevent their fast decomposition. Advancing the development of air- and moisture-compatible polar organometallic chemistry, the chemoselective and ultrafast amidation of esters mediated by lithium amides is reported. Establishing a novel sustainable access to carboxamides, this has been accomplished via direct C-O bond cleavage of a range of esters using glycerol or 2-MeTHF as a solvent, in air. High yields and good selectivity are observed while operating at ambient temperature, without the need for transition-metal mediation, and the protocol extends to transamidation processes. Pre-coordination of the organic substrate to the reactive lithium amide as a key step in the amidation processes has been assessed, enabling the structural elucidation of the coordination adduct [{Li(NPh2)(OCPh(NMe2))}2] (8) when toluene is employed as a solvent. No evidence for formation of a complex of this type has been found when using donor THF as a solvent. Structural and spectroscopic insights into the constitution of selected lithium amides in 2-MeTHF are provided that support the involvement of small kinetically activated aggregates that can react rapidly with the organic substrates, favouring the C-O bond cleavage/C-N bond formation processes over competing hydrolysis/degradation of the lithium amides by moisture or air.

Palladium-catalyzed aminocarbonylation of aryl iodides with amides and N-alkyl anilines

A novel and efficient palladium-catalyzed aminocarbonylation of aryl iodides with amides and N-alkyl anilines has been developed. The reaction tolerates a wide range of functional groups and is a reliable method for the rapid synthesis of a variety of valuable imides and tertiary benzanilides under an atmospheric pressure of CO. Copyright