379697-34-4Relevant academic research and scientific papers
A convenient access to benzo-substituted phthalazines as potential precursors to DNA intercalators
Tsoungas, Petros G,Searcey, Mark
, p. 6589 - 6592 (2001)
2-Nitro-5-methoxybenzaldehyde is converted to amines 2 and 7 via two alternative routes. Upon diazotisation and Sandmeyer reaction, halides 4 and 9 are formed, which, through lithiation and formylation lead to the o-phthalaldehyde. Further cyclisation with hydrazine gives the 5-methoxy-substituted phthalazine.
