38035-10-8

Basic information

• Product Name: 4-(Dimethylamino)tetrahydro-2H-pyran
• Synonyms: N,N-DIMETHYL TETRAHYDRO-2H-PYRAN-4-AMINE;N,N-Dimethylamine tetrahydro-2H-pyran;TETRAHYDRO-2H-PYRAN-4-DIMETHYLAMINE;4-(Dimethylamino)tetrahydro-2H-pyran;tetrahydro-N,N-dimethyl-2H-pyran-4-amine;N,N-dimethyloxan-4-amine
• CAS NO: 38035-10-8
• Molecular Formula: C₇H₁₅NO
• Molecular Weight: 129.2
• Mol File: 38035-10-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 172.28 °C at 760 mmHg
• Flash Point: 47.284 °C
• Appearance: /
• Density: 0.928 g/cm³
• Vapor Pressure: 1.341mmHg at 25°C
• Refractive Index: 1.458
• CAS DataBase Reference: 4-(Dimethylamino)tetrahydro-2H-pyran(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(Dimethylamino)tetrahydro-2H-pyran(38035-10-8)
• EPA Substance Registry System: 4-(Dimethylamino)tetrahydro-2H-pyran(38035-10-8)

Safety Data

• Hazardous Substances Data: 38035-10-8(Hazardous Substances Data)

Usage

General Description

4-(Dimethylamino)tetrahydro-2H-pyran is a chemical compound that is commonly used as a building block in organic synthesis. It is a cyclic amine with a tetrahydro-2H-pyran ring and a dimethylamino group attached to one of the carbon atoms. 4-(Dimethylamino)tetrahydro-2H-pyran has potential applications in the pharmaceutical and agrochemical industries, particularly in the development of new drugs and crop protection agents. It is known for its ability to participate in various chemical reactions, making it a versatile and valuable intermediate in organic chemistry. Additionally, 4-(Dimethylamino)tetrahydro-2H-pyran may also have uses as a fragrance or flavoring agent in the food and cosmetic industries due to its unique chemical structure.

InChI:InChI=1/C7H15NO/c1-8(2)7-3-5-9-6-4-7/h7H,3-6H2,1-2H3

Upstream product

• 38041-19-9 4-aminotetrahydropyran 
• 50-00-0 formaldehyd 
• 29943-42-8 Tetrahydro-4H-pyran-4-one 
• 124-40-3 dimethyl amine 
• 68-12-2 N,N-dimethyl-formamide 

Downstream Products

• 229005-82-7 N,N-dimethyl-N-[4-[[[7-(4-ethoxyphenyl)-2,3-dihydro-1-benzoxepin-4-yl]carbonyl]amino]benzyl]-N-(tetrahydropyran-4-yl)ammonium chloride 
• 229005-80-5 TAK-779 

Relevant articles and documents

Processes for producing tetrahydropyranyl-4-sulfonates and 4-aminotetrahydropyran compound

The present invention is to provide a process for producing a tetrahydropyranyl-4-sulfonate which comprises allowing 3-buten-1-ol which is easily available to react with a formaldehyde compound and an organic sulfonic acid, and a process for producing a 4-aminotetrahydropyrane derivative, which is industrially useful, under mild conditions and by a simple and easy method to produce the 4-aminotetrahydropyrane derivative in high yield.

Development of a new synthetic route of a non-peptide CCR5 antagonist, TAK-779, for large-scale preparation

A new large-scalable preparation of TAK-779 (1), a non-peptide CCR5 antagonist, has been developed. The route selection was focused on in the process research. The selective reduction of commercially available benzonitrile derivative (4) as the starting material with sodium bis(2-methoxyethoxy)aluminum hydride followed by the Wittig reaction, hydrogenation, and intramolecular acylation gave benzocycloheptanone (7) in good yield. The conversion of α,α-unsaturated carboxylic acid (8) led from 7 to benzyl alcohol (9) and shortened the number of steps using non-protected 4-aminobenzyl alcohol. The reductive alkylation of Me2NH and tetrahydro-4H-pyran-4-one (12) smoothly gave a tertiary amine (3). The coupling of 2 chlorinated 9, and 3 successfully led to an ammonium chloride (1). A new inexpensive preparation which did not require a chromatographic method was achieved.

Anilide derivative, production and use thereof

This invention is to provide a compound of the formula: wherein R1 is an optionally substituted 5- to 6-membered ring: C is a divalent group of the formula: wherein the ring A is an optionally substituted 5- to 6-membered aromatic ring, X is an optionally substituted C, N or O atom, and the ring B is an optionally substituted 5- to 7-membered ring; Z is a chemical bond or a divalent group; R2 is (1) an optionally substituted amino group in which a nitrogen atom may form a quaternary ammonium, etc., or a salt thereof, which is useful for antagonizing MCP-1 receptor.