38052-67-4

Upstream product

• 4461-33-0 benzoyl isocyanate 
• 18107-18-1 diazomethyl-trimethyl-silane 
• 1468-39-9 Isovaleric anhydride 

Downstream Products

• 19340-77-3 N-Phenylmethyl hydroxyacetamide 
• 163936-42-3 trifluoromethanesulfonic acid 2-phenyl-oxazol-4-yl ester 
• 1402942-08-8 C₁₃H₁₅NO₃ 
• 1402942-54-4 2-phenyl-1,3-oxazolidin-4-one 
• 425605-13-6 (R)-4-phenyl-3-(2-phenylethynyl)oxazolidin-2-one 
• 503590-28-1 (R)-4-phenyl-3-(2-triisopropylsilylethynyl)oxazolidin-2-one 

Relevant academic research and scientific papers

Catalytic, enantioselective N-acylation of lactams and thiolactams using amidine-based catalysts

In contrast to alcohols and amines, racemic lactams and thiolactams cannot be resolved directly via enzymatic acylation or classical resolution. Asymmetric N-acylation promoted by amidine-based catalysts, particularly Cl-PIQ 2 and BTM 3, provides a convenient method for the kinetic resolution of these valuable compounds and often achieves excellent levels of enantioselectivity in this process. Density functional theory calculations indicate that the reaction occurs via N-acylation of the lactim tautomer and that cation-π interactions play a key role in the chiral recognition of lactam substrates.

Synthesis of vinyl-functionalized oxazoles by olefin cross-metathesis

(Chemical Equation Presented) A ruthenium-based catalyzed olefin cross-methathesis reaction involving 2- and 4-vinyl-functionalized oxazoles was developed. A wide range of olefinic partners was coupled in good to excellent yields and high stereoselectivities under mild conditions. This methodology offers new opportunities for the synthesis of a plethora of biologically active natural products.