19340-77-3

Basic information

• Product Name: N-BENZYL-2-HYDROXYACETAMIDE
• Synonyms: N-BENZYL-2-HYDROXYACETAMIDE
• CAS NO: 19340-77-3
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.19
• Mol File: 19340-77-3.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 398.1°Cat760mmHg
• Flash Point: 194.6°C
• Appearance: /
• Density: 1.161g/cm³
• Vapor Pressure: 4.73E-07mmHg at 25°C
• Refractive Index: 1.554
• CAS DataBase Reference: N-BENZYL-2-HYDROXYACETAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-BENZYL-2-HYDROXYACETAMIDE(19340-77-3)
• EPA Substance Registry System: N-BENZYL-2-HYDROXYACETAMIDE(19340-77-3)

Safety Data

• Hazardous Substances Data: 19340-77-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11NO2/c11-7-9(12)10-6-8-4-2-1-3-5-8/h1-5,11H,6-7H2,(H,10,12)

Upstream product

• 38052-67-4 2-phenyl-1,3-oxazolidin-4-one 
• 13831-30-6 acetoxyacetic acid 
• 100-46-9 benzylamine 
• 50-00-0 formaldehyd 
• 88333-03-3 Benzyl isocyanide 
• 3551-78-8 N,N'-dibenzylethanediamide 
• 107-21-1 ethylene glycol 
• 105310-97-2 N-benzyl-α-diazoacetamide 
• 507-09-5 tiolacetic acid 
• 107-96-0 3-mercaptopropionic acid 
• 4530-20-5 BOC-glycine 
• 99-96-7 4-hydroxy-benzoic acid 
• 65-85-0 benzoic acid 
• 79-43-6 dichloro-acetic acid 

Downstream Products

• 99856-03-8 methoxycarbonyloxy-acetic acid benzylamide 
• 19340-78-4 Phenylacetoxyessigsaeure-benzylamid 
• 17153-22-9 benzylcarbamoyloxy-acetic acid 
• 21775-46-2 N-p-Anisyl-N'-benzyloxamid 
• 17153-05-8 N-benzyl-oxazolidine-2,4-dione 
• 67823-89-6 3-benzyl-2-methyl-oxazolidin-4-one 
• 67823-90-9 3-benzyl-2-phenyl-1, 3-oxazolidine-4(5H)-one 

Relevant articles and documents

CATALYST FOR CONVERTING ESTER TO AMIDE USING HYDROXYL GROUP AS ORIENTATION GROUP

Provided is a method for amidating a hydroxy ester compound at a high chemical selectivity. The amidation reaction method for a hydroxy ester compound comprises, in the presence of a catalyst containing a compound of a transition metal of the group 4 or group 5 in the periodic table, reacting at least one kind of hydroxy ester compound selected from the group consisting of an α-hydroxy ester compound, a β-hydroxy ester compound, a γ-hydroxy ester compound and a δ-hydroxy ester compound with an amino compound so as to amidate an ester group having a hydroxyl group at the α-, β-, γ- or δ-position of the hydroxy ester compound.

Reagents and methods for esterification

A method for esterification of one or more carboxylic acid groups in a compound containing one or more carboxylic acid groups wherein the esterification reagent is a diazo-compound of formula: wherein the R1 and R2 groups of the diazo compound are selected such that the corresponding organic compound of formula: exhibits a —C—H pKa value between 18 and 29 as measured in DMSO. Specific reagents and methods for esterification are provided. The esterification reagents provided exhibit high selectivity for esterification of carboxylic acid groups over reaction with amine, alcohol or thiol groups in the compound containing one or more carboxylic acid groups. The method can be used to selectively esterify carboxylic acid groups in peptides or proteins.

The use of 2-hydroxymethyl benzoic acid as an effective water surrogate in the Passerini reaction: A straightforward access to α-hydroxyamides

Dozens of strategies have been described for the synthesis of α-hydroxyamides over the years, but they share common drawbacks in terms of generality and tolerability, especially to acid labile functionalities. Here we report a truncated Passerini reaction suitable for the easy and mild preparation of functionalized α-hydroxyamides. In particular, this procedure is tolerant to acid sensitive protecting groups, which remain intact during the multicomponent reaction.