38063-81-9

Usage

Uses

Used in Organic Synthesis:
4-Aminoacetophenone oxime is used as a building block in the synthesis of heterocyclic compounds, which are essential in the creation of various organic compounds with unique properties and applications.
Used in Pharmaceutical Development:
4-AMINOACETOPHENONE OXIME is utilized in the development of drugs for the treatment of a range of diseases, highlighting its importance in the pharmaceutical industry.
Used in Analytical Chemistry:
4-Aminoacetophenone oxime serves as a reagent for the determination of various metal ions in solution, which is crucial for analytical and environmental chemistry applications.

InChI:InChI=1/C8H10N2O/c1-6(10-11)7-2-4-8(9)5-3-7/h2-5,11H,9H2,1H3/b10-6+

Upstream product

• 99-92-3 p-aminobenzophenone 
• 10342-64-0 p-nitroacetophenone oxime 

Downstream Products

• 38063-88-6 2-[1-(4-amino-phenyl)-ethylideneaminooxy]-N-(2-morpholin-4-yl-ethyl)-N-phenyl-acetamide 
• 38063-89-7 4-{[1-(4-amino-phenyl)-ethylideneaminooxy]-acetyl}-morpholine 
• 129993-17-5 1-vinyl-2-(4-aminophenyl)pyrrole 
• 134703-22-3 2-(4-aminophenyl)pyrrole 
• 134703-24-5 O-vinyl-4-aminoacetophenone oxime 
• 99-92-3 p-aminobenzophenone 
• 122-80-5 N-acetyl-p-phenylenediamine 
• 32479-14-4 C₁₅H₁₇N₃O₂S 
• 32479-13-3 N-(α-Methyl-p-phenylazobenzyl)-α-naphthamid 
• 1202385-74-7 4-amino-3-iodoacetophenone oxime 
• 1446947-62-1 1-(4-{[(E)-3,5-dibromo-2-hydroxybenzylidene]amino}-phenyl)ethanone oxime 
• 1597446-27-9 (Z)-4-({4-[1-(hydroxyimino)ethyl]phenylimino}(phenyl)methyl)-3-methyl-1-phenyl-1H-pyrazol-5(4H)-one 
• 75270-71-2 p-salicyliden-p-aminoacetophenone oxime 

Relevant academic research and scientific papers

Beckmann rearrangement of ketoximes promoted by cyanuric chloride and dimethyl sulfoxide under a mild condition

Synthesis of amides via Beckmann rearrangement of ketoximes promoted by cyanuric chloride (TCT)/DMSO under mild conditions has been reported. Conditions of the Beckmann rearrangement, e.g., solvents, the ratios of TCT/DMSO, and the temperature, were investigated using diphenylmethanone oxime as a substrate. The optimized conditions were adopted to afford fourteen amides with yields ranging from 20% to 99%. A plausible mechanism involving an active dimethyl alkoxysulfonium intermediate was proposed according to the mass spectrometry analysis. To our best knowledge, this is the first case of study on Beckmann rearrangement of ketoximes promoted by TCT/DMSO under a mild condition to afford amides efficiently.

Commercially Available CuO Catalyzed Hydrogenation of Nitroarenes Using Ammonia Borane as a Hydrogen Source

Tandem ammonia borane dehydrogenation and nitroarenes hydrogenation has been reported as a novel strategy for the preparation of aromatic amines. However, the practical application of this strategy is subjected to the high-cost and tedious preparation of supported noble metal nanocatalysts. The commercially available CuO powder is herein demonstrated to be a robust catalyst for hydrogenation of nitroarenes using ammonia borane as a hydrogen source under mild conditions. Numerous amines (even sterically hindered, halogenated, and diamines) could be obtained through this method. This monometallic catalyst is characteristic of support-free, excellent chemoselectivity, low-cost, and high recyclability, which will favor its future utilization in preparative reduction chemistry. Mechanistic studies are also carried out to clarify that diazene and azoxybenzene are key intermediates of this heterogeneous reduction.

Method for preparing aromatic amine compounds from aromatic nitro compounds by catalytic reduction of nano porous gold catalyst

The invention discloses a method for preparing aromatic amine compounds from aromatic nitro compounds by catalytic reduction of a nano porous gold catalyst. The nano porous gold catalyst and the aromatic nitro compounds are taken as substrates and subjected to a reaction in methanol with ammonia borane as a hydrogen source at the room temperature, and a product is obtained. The high probability ofagglomeration of conventional granular catalysts is prevented, the nano porous gold catalyst shows excellent structural stability and good recycling efficiency, has excellent universality, especiallyfor the aromatic nitro compounds, and has green and mild catalytic conditions, high yield and good selectivity. The yield of m-nitroaniline from m-nitrotoluene can reach 98%. Moreover, the catalyst can be centrifugally recovered and can be recycled without other treatment, the yield of preparing m-nitroaniline from m-nitrotoluene by catalyzing can still reach 88% after being recycled five times,and thus, waste is effectively avoided. The catalyst shows high activity during the reaction and excellent stability under the reaction conditions.

SO2F2-Activated Efficient Beckmann Rearrangement of Ketoximes for Accessing Amides and Lactams

A novel, mild and practical protocol for the efficient activation of the Beckmann rearrangement utilizing the readily available and economical sulfuryl fluoride (SO2F2 gas) has been developed. The substrate scope of the operationally simple methodology has been demonstrated by 37 examples with good to nearly quantitative isolated yields (over 90 % yield in most cases) in a short time, including B(OH)2, COOH, NH2, and OH substituted substrates. A tentative mechanism was proposed involving formation and elimination of key intermediate, sulfonyl ester.

Copper-Catalyzed Three-Component Domino Cyclization for the Synthesis of 4-Aryl-5-(arythio)-2-(trifluoromethyl)oxazoles

A copper-catalyzed oxidative cyclization of oxime, arylthiol, and trifluoroacetic anhydride for the construction of trisubstituted oxazoles has been developed. This transformation combines N-O bond cleavage, C-H functionalization, and intramolecular annulation, providing a practical protocol for the introduction of a trifluoromethyl (-CF3) group at oxazole rings.

Mild, calcium catalysed Beckmann rearrangements

A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.

Magnetic nanoparticles supported oxime palladacycle as a highly efficient and separable catalyst for room temperature Suzuki-Miyaura coupling reaction in aqueous media

A novel magnetic nanoparticle-supported oxime palladacycle catalyst was successfully prepared and characterized. The magnetically recoverable catalyst was evaluated in the room temperature Suzuki-Miyaura cross-coupling reaction of aryl iodides and bromides in aqueous media. The catalyst was shown to be highly active under phosphine-free and low Pd loading (0.3 mol%) conditions. The catalyst could be easily separated from the reaction mixture using an external magnet and reused for six consecutive runs without significant loss of activity.

APPLICATIONS OF N6-SUBSTITUTED ADENOSINE DERIVATIVE AND N6-SUBSTITUTED ADENINE DERIVATIVE TO CALMING, HYPNOSES, CONVULSION RESISTANCE, EPILEPTIC RESISTANCE, PARKINSON DISEASE RESISTANCE, AND DEMENTIA PREVENTION AND TREATMENT

PROBLEM TO BE SOLVED: To prepare analgesics, hypnotic agents, anticonvulsant agents, antiepileptics, antiparkinson drugs, dementia prophylactics, and health care food. SOLUTION: The present invention relates to an N6-substituted adenosine derivative and an N6-substituted adenine derivative selected from the group consisting of specific compounds. The present invention also relates to a pharmaceutical composition at least comprising a therapeutically effective amount of the compounds and a pharmaceutically acceptable carrier. The invention further relates to the compounds used in preparation of analgesics, hypnotic agents, anticonvulsant agents, antiepileptics, antiparkinson drugs, dementia prophylactics, and health care food. COPYRIGHT: (C)2016,JPO&INPIT

N6-SUBSTITUTED ADENOSINE DERIVATIVES AND N6-SUBSTITUTED ADENINE DERIVATIVES AND USES THEREOF

The present invention provides N6-substituted adenosine derivatives and N6-substituted adenine derivatives, manufacturing methods thereof, a pharmaceutical composition comprising the said compounds above, and uses of these compounds in manufacturing medicaments and health-care products for treating insomnia, convulsion, epilepsy, and Parkinson's diseases, and preventing and treating dementia.

Synthesis, crystal and supermolecular structure of (Z)-4-({4-[1- (Hydroxyimino)ethyl]-phenylimino}(phenyl)methyl)-3-methyl-1-phenyl-1H-pyrazol- 5(4H)-one

The compound, (Z)-4-({4-[1-(hydroxyimino)ethyl]phenylimino}(phenyl)methyl)- 3-methyl-1-phenyl-1H-pyrazol-5(4H)-one has been synthesized and characterized by elemental analyses, IR spectra and X-ray diffraction method. This compound is a potential tridenta