380653-16-7

Basic information

• Product Name: 2-(3-phenyl-1,2,4-oxadiazole-5-yl) benzenethiol
• Synonyms: 2-(3-phenyl-1,2,4-oxadiazole-5-yl) benzenethiol
• CAS NO: 380653-16-7
• Molecular Weight: 254.312
• Mol File: 380653-16-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(3-phenyl-1,2,4-oxadiazole-5-yl) benzenethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3-phenyl-1,2,4-oxadiazole-5-yl) benzenethiol(380653-16-7)
• EPA Substance Registry System: 2-(3-phenyl-1,2,4-oxadiazole-5-yl) benzenethiol(380653-16-7)

Safety Data

• Hazardous Substances Data: 380653-16-7(Hazardous Substances Data)

Upstream product

• 1670-14-0 benzamidine monohydrochloride 
• 147-93-3 Thiosalicylic acid 
• 98051-92-4 (disulfanediylbis(2,1-phenylene))bis(1H-benzo[d][1,2,3]triazol-1-yl)methanone 
• 100-47-0 benzonitrile 
• 119-80-2 2,2'-dithiobenzoic acid 
• 613-92-3 N-hydroxyl-benzamidine 
• 1374773-76-8 1,2-bis(2-(3-phenyl-1,2,4-oxadiazol-5-yl)phenyl)disulfane 

Downstream Products

• 1374754-49-0 4,4-dibutyl-2-phenyl-4H-benzo[e][1,3]thiazine 

Relevant articles and documents

A metal-free tandem approach to prepare structurally diverse N-heterocycles: Synthesis of 1,2,4-oxadiazoles and pyrimidinones

A metal-free one-pot approach to the diversity oriented synthesis of N-heterocycles, 1,2,4-oxadiazoles and 2,6 disubstituted pyrimidin-4-ones is described via carboxamidation of amidines with aryl carboxylic acids and aryl propargylic acids. The reactions occur at room temperature forming N-acylamidines which undergo tandem nucleophilic addition-deamination- intramolecular cyclisation to give the corresponding heterocyclic compounds in good to excellent yields. This one pot approach has led to the successful synthesis of the drug lead molecule, ataluren, 3-(5-(2-fluorophenyl)-1,2,4- oxadiazol-3-yl) benzoic acid in two steps. the Partner Organisations 2014.