381220-85-5

Upstream product

• 100-39-0 benzyl bromide 
• 120-80-9 benzene-1,2-diol 
• 2420-26-0 4-chlorosalicylaldehyde 
• 937-14-4 3-chloro-benzenecarboperoxoic acid 
• 6272-38-4 O-benzylcatechol 

Downstream Products

• 847148-61-2 2-[2-(benzyloxy)-4-chlorophenoxy]-2-methylpropanoic acid 
• 1289486-13-0 4-(3-((2-(benzyloxy)-4-chlorophenoxy)methyl)phenyl)-4-methoxytetrahydro-2H-pyran 
• 1261736-99-5 5-chloro-2-(difluoromethoxy)phenol 
• 847148-62-3 2-(4-chloro-2-hydroxyphenoxy)-2-methylpropionic acid 

Relevant academic research and scientific papers

1,3 DI-SUBSTITUTED CYCLOBUTANE OR AZETIDINE DERIVATIVES AS HEMATOPOIETIC PROSTAGLANDIN D SYNTHASE INHIBITORS

A compound of formula (I), wherein R, R1, R2, R3, Y, Y1, a, X, and Z are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne Muscular Dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase

Cyclooxygenase-1/2 (COX-1/2) and 5-lipoxygenase (5-LOX) are enzymes in two different pathways in the inflammatory process. In the present study, a variety of new nimesulide derivatives were synthesized through incorporation of a 5-LOX pharmacophore into nimesulide followed with some structural modifications, which were then characterized for dual enzyme inhibitors for these two types of enzymes. Their structure-activity relationships (SARs) were studied, and compound 20f was found to be an excellent dual enzyme inhibitor. Its binding conformation and interaction mode were studied with molecular docking experiments. Compound 20f could become a lead compound for further development for potential anti-inflammatory drugs.

PHENOXIACETIC ACID DERIVATIVES

The invention relates to certain 2-substituted phenoxyacetic acid derivatives of formula (I), in which the variables are as defined in the claims, useful in the treatment of diseases or conditions in which modulation of the CRTh2 receptor is beneficial, s