381233-79-0 Usage
Uses
Used in Coordination Chemistry:
5'-Bromo-[2,3'-bipyridin]-6'(1'H)-one is used as a ligand for forming stable complexes with metal ions. Its ability to coordinate with metals makes it a valuable component in the synthesis of coordination compounds.
Used in Catalysis:
BpyBr is used as a catalyst or catalyst precursor in various chemical reactions. Its coordination with metal ions can enhance the catalytic activity and selectivity of the reactions.
Used in Material Science:
5'-Bromo-[2,3'-bipyridin]-6'(1'H)-one is used in the development of new materials, such as metal-organic frameworks (MOFs) and coordination polymers, due to its ability to form stable complexes with metal ions.
Used in Pharmaceutical Research:
BpyBr is used as a building block or intermediate in the synthesis of pharmaceutical compounds. Its unique structure and properties can contribute to the development of new drugs with improved efficacy and selectivity.
Used in Analytical Chemistry:
5'-Bromo-[2,3'-bipyridin]-6'(1'H)-one can be used as a reagent or reference compound in analytical techniques, such as spectroscopy and chromatography, for the detection and analysis of various substances.
Check Digit Verification of cas no
The CAS Registry Mumber 381233-79-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,8,1,2,3 and 3 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 381233-79:
(8*3)+(7*8)+(6*1)+(5*2)+(4*3)+(3*3)+(2*7)+(1*9)=140
140 % 10 = 0
So 381233-79-0 is a valid CAS Registry Number.
381233-79-0Relevant academic research and scientific papers
PROCESS FOR THE PREPARATION OF PERAMPANEL
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Paragraph 0059, (2016/04/26)
The present invention relates to processes for the preparation of perampanel and its intermediates.
Discovery of 2-(2-Oxo-1-phenyl-5-pyridin-2-yl-1,2-dihydropyridin-3-yl) benzonitrile (Perampanel): A novel, noncompetitive α-amino-3-hydroxy-5- methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonist
Hibi, Shigeki,Ueno, Koshi,Nagato, Satoshi,Kawano, Koki,Ito, Koichi,Norimine, Yoshihiko,Takenaka, Osamu,Hanada, Takahisa,Yonaga, Masahiro
, p. 10584 - 10600 (2013/02/23)
Dysfunction of glutamatergic neurotransmission has been implicated in the pathogenesis of epilepsy and numerous other neurological diseases. Here we describe the discovery of a series of 1,3,5-triaryl-1H-pyridin-2-one derivatives as noncompetitive antagonists of AMPA-type ionotropic glutamate receptors. The structure-activity relationships for this series of compounds were investigated by manipulating individual aromatic rings located at positions 1, 3, and 5 of the pyridone ring. This culminated in the discovery of 2-(2-oxo-1-phenyl-5- pyridin-2-yl-1,2-dihydropyridin-3-yl)benzonitrile (perampanel, 6), a novel, noncompetitive AMPA receptor antagonist that showed potent activity in an in vitro AMPA-induced Ca2+ influx assay (IC50 = 60 nM) and in an in vivo AMPA-induced seizure model (minimum effective dose of 2 mg/kg po). Perampanel is currently in regulatory submission for partial-onset seizures associated with epilepsy.
