381248-06-2

Basic information

• Product Name: 5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one
• Synonyms: 5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one;3-BroMo-1-phenyl-5-(pyridin-2-yl)pyridin-2(1H)-one;3-Bromo-1-phenyl-5-(pyridin-2-yl)-1,2-dihydropyridin-2-one;3-Bromo-1-phenyl-5-(pyridin-2-yl)-2(1H)-pyridone;3-Bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one
• CAS NO: 381248-06-2
• Molecular Formula: C₁₆H₁₁BrN₂O
• Molecular Weight: 327.17534
• Mol File: 381248-06-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 461.7±45.0 °C(Predicted)
• Appearance: /
• Density: 1.539±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: 4.73±0.19(Predicted)
• Stability: Light Sensitive
• CAS DataBase Reference: 5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one(381248-06-2)
• EPA Substance Registry System: 5'-broMo-1'-phenyl-[2,3'-bipyridin]-6'(1'H)-one(381248-06-2)

Safety Data

• Hazardous Substances Data: 381248-06-2(Hazardous Substances Data)

Usage

Uses

3-Bromo-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one is an intermediate in the synthesis of Perampanel (P285522), an antiepileptic drug.

Upstream product

• 197958-29-5 pyridin-2-ylboronic acid 
• 381233-79-0 3-bromo-5-(2-pyridyl)-1,2-dihydropyridin-2-one 
• 98-80-6 phenylboronic acid 
• 163105-89-3 2-methoxy-pyridine-5-boronic acid 
• 381725-49-1 2-methoxy-5-(pyridin-2-yl)pyridine 
• 17997-47-6 2-tri-n-butylstannylpyridine 
• 381233-78-9 5-(2-Pyridyl)-1,2-dihydropyridin-2-one 
• 13472-85-0 2-methoxy-5-bromopyridine 
• 624-28-2 2,5-dibromopyridine 
• 381725-50-4 1-phenyl-5-(pyridin-2-yl)-2(1H)-pyridone 

Downstream Products

• 380917-97-5 [14C]-Perampanel 
• 380918-50-3 C₂₃H₁₈N₂O 

Relevant articles and documents

NOVEL PROCESS FOR THE PREPARATION OF PERAMPANEL AND ITS INTERMEDIATES THEREOF

The present invention provides novel process for preparation of 3-(2-cyanophenyl)-5-(2- pyridyl)-1-phenyl-1,2-dihydropyridin-2-one, commonly known as perampanel having the formula I. The present invention also provides novel intermediate compound of formula VI and process for the preparation of intermediate compound of formula VI. The present invention also provides purification of perampanel.

A practical, laboratory-scale synthesis of Perampanel

The orally active, noncompetitive, selective AMPA receptor antagonist Perampanel, 2-[1,6-dihydro-6-oxo-1-phenyl-(2,3-bipyridin)-5-yl]benzonitrile, has been prepared from readily available, relatively inexpensive starting materials. The synthesis was carried out on a laboratory scale with no specialized equipment, and involved only two chromatographic purifications. Georg Thieme Verlag Stuttgart. New York.

CRYSTAL OF 1,2-DIHYDROPYRIDINE COMPOUND (TYPE IV)

A crystal of 3-(2-cyanophenyl)-5-(2-pyridyl)-1-phenyl-1,2-dihydropyridin-2-one characterized in having a diffraction peak at a diffraction angle (2θ±0.2°) of 15.4° in a powder X-ray diffraction or others.