3815-60-9Relevant academic research and scientific papers
A facile method for the preparation of carbodiimides from thioureas and (Boc)2O
Wu, He,Sun, Yan-Fang,Zhang, Chen,Miao, Chun-Bao,Yang, Hai-Tao
, p. 739 - 742 (2018/01/27)
A concise method for the preparation of carbodiimides from thioureas using di-tert-butyl dicarbonate [(Boc)2O] as the dehydrosulfurizative reagent has been developed. Using DMAP as the catalyst, a variety of symmetric and asymmetric 1,3-diaryl thioureas were converted into the corresponding carbodiimides efficiently in a short time.
Palladium-catalyzed cross-coupling reaction of azides with isocyanides
Zhang, Zhen,Li, Zongyang,Fu, Bin,Zhang, Zhenhua
, p. 16312 - 16315 (2015/11/16)
An efficient palladium-catalyzed cross-coupling reaction of azides with isocyanides is developed, providing a general synthetic route to unsymmetric carbodiimides with excellent yields. This method shows a broad substrate scope, including not only aryl azides, but also unactivated benzyl and alkyl azides. Furthermore, from readily available substrates, Pd-catalyzed coupling with a tandem amine insertion cascade to obtain unsymmetric trisubstituted guanidines has been achieved in a one-pot fashion.
Synthesis of phosphaguanidines by hydrophosphination of carbodiimides with phosphine boranes
Busacca, Carl A.,Milligan, John A.,Rattanangkool, Eakkaphon,Ramavarapu, Cyrus,Chen, Anji,Saha, Anjan K.,Li, Zhibin,Lee, Heewon,Geib, Steven J.,Wang, Guijun,Senanayake, Chris H.,Wipf, Peter
, p. 9878 - 9887 (2015/01/09)
The direct addition of anionic secondary phosphine boranes to carbodiimides yields both chiral and achiral phosphaguanidine boranes under ambient temperature conditions. An analogous preparation of menthol-derived phosphinite boranes is also described. These products can be deborinated to give the corresponding phosphines, and subsequently oxidized to give phosphine oxides. The robustness of this method was further demonstrated in the synthesis of structurally novel cyclic phosphaguanidines. (Chemical Equation Presented).
A New synthetic protocol for the preparation of carbodiimides using a hypervalent iodine(III) reagent
Zhu, Chenjie,Xu, Dan,Wei, Yunyang
supporting information; experimental part, p. 711 - 714 (2011/04/24)
A new, simple, and efficient preparation of symmetrical and unsymmetrical carbodiimides from the corresponding thioureas via dehydrosulfurization using a hypervalent iodine(III) reagent is described. The oxidation afforded carbodiimides in excellent yields and high selectivity. A possible mechanism for the transformation is proposed. Georg Thieme Verlag Stuttgart New York.
