60404-64-0

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 
• 3717-21-3 p-methoxyl benzaldoxime 
• 62-53-3 aniline 
• 38435-51-7 N-hydroxy-4-methoxy-benzenecarboximidoyl chloride 

Downstream Products

• 63105-03-3 4-(4-methoxy-phenyl)-3-phenyl-3H-[1,2,3,5]oxathiadiazole 2-oxide 
• 2620-81-7 2-(4-methoxyphenyl)-1H-benzimidazole 
• 3815-60-9 4-methoxy-N-((phenylimino)methylene)aniline 
• 3746-53-0 N-(4-metoxyphenyl)-N'-phenylurea 
• 838-34-6 2-(p-methoxyphenyl)benzoxazole 

Relevant academic research and scientific papers

Iodine Promoted One-Pot Synthesis of 2-Aryl Benzoxazoles from Amidoximes via Oxidative Cyclization and Ring Contraction

A molecular I2-promoted one-pot synthesis of 2-aryl benzoxazoles has been developed by using amidoximes rather than the limited 2-aminophenols or 2-haloamides as substrates. The amidoxime substrates provided unique and efficient strategies for converting readily available aniline and benzaldehyde precursors into valuable chemicals. This transformation proceeded smoothly under transition-metal-free conditions through a sequential oxidative cyclization and ring contraction, and provided a potential route for introducing certain groups at any site of the scaffold.

Practical synthesis of N -substituted cyanamides via tiemann rearrangement of amidoximes

A facile and general synthesis of various N-substituted cyanamides was accomplished by the Tiemann rearrangement of amidoximes with benzenesulfonyl chlorides (TsCl or o-NsCl) and DIPEA.