38152-19-1Relevant academic research and scientific papers
Cobalt-Catalyzed Esterification of Amides
Bourne-Branchu, Yann,Gosmini, Corinne,Danoun, Grégory
, p. 10043 - 10047 (2017)
The first cobalt-catalyzed amide activation of N-Boc-amides, and their conversion into esters, is reported here. This new methodology presents a very practical process that does not require an inert atmosphere, uses an inexpensive cobalt catalyst, and proceeds under mild reaction conditions. This catalytic system has a broad substrate scope and has been shown to be highly efficient, with catalyst loadings as low as 1 mol %.
