38175-27-8

Usage

Uses

Used in Organic Synthesis:
(3,4-dimethoxy-phenyl)-succinic acid is used as a building block in organic synthesis for the creation of various organic compounds. Its unique structure and solubility profile make it a valuable component in the synthesis of complex molecules.
Used in the Food Industry:
In the food industry, (3,4-dimethoxy-phenyl)-succinic acid is used as a flavoring agent. Its ability to impart specific flavors to food products makes it a useful ingredient in the development of new and innovative food items.
Used in Pharmaceutical Development:
(3,4-dimethoxy-phenyl)-succinic acid is studied for its potential therapeutic applications, particularly for its anti-inflammatory and antioxidative properties. Its presence in pharmaceutical drugs could contribute to the treatment and management of various health conditions.
Used in Drug Development:
Furthermore, (3,4-dimethoxy-phenyl)-succinic acid has been investigated for its potential use in the development of new pharmaceutical drugs. Its unique chemical properties may offer novel pathways for drug discovery and the treatment of diseases.
Used as a Precursor in Synthesis:
Additionally, (3,4-dimethoxy-phenyl)-succinic acid serves as a precursor in the synthesis of various other organic compounds. Its role in the formation of these compounds is crucial for the advancement of organic chemistry and the creation of new materials and products.

Upstream product

• 64-17-5 ethanol 
• 24393-47-3 ethyl (E)-2-cyano-3-(3,4-dimethoxyphenyl)-2-propenoate 
• 151-50-8 potassium cyanide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 105-56-6 ethyl 2-cyanoacetate 
• 2286-55-7 ethyl α-cyano-β-(3,4-dimethoxyphenyl)acrylate 

Downstream Products

• 19156-11-7 5,6-dimethoxyindan-1-carboxylic acid 
• 317817-76-8 (3S,7aR)-6-(3,4-Dimethoxy-phenyl)-3-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 

Relevant academic research and scientific papers

Discovery, stereospecific characterization and peripheral modification of 1-(pyrrolidin-1-ylmethyl)-2-[(6-chloro-3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinolines as novel selective κ opioid receptor agonists

A novel series of 1-(pyrrolidin-1-ylmethyl)-2-[(3-oxo-indan)-formyl]-1,2,3,4-tetrahydroisoquinoline derivatives maj-3a-maj-3u were synthesized and evaluated in vitro for their binding affinity at κ-opioid receptors. Maj-3c displayed the highest affinity for κ-opioid receptors (Ki = 0.033 nM) among all the compounds evaluated. Furthermore, all four stereoisomers of compound 3c were prepared, and (1S,18S)-3c was identified as the most potent (Ki = 0.0059 nM) κ-opioid receptor agonist among the four stereoisomers. Maj-3c produced significant antinociception (ED50 = 0.000406 mg kg-1) compared to U-50,488H and original BRL 52580 in the acetic acid writhing assay, but its strong sedative effect (ED50 = 0.000568 mg kg-1) observed in the mouse rotation test reduced its druggability. To minimize the central nervous system side effects, a series of hydroxyl-containing analogs of maj-3c were synthesized, and maj-11a was found to be a potent κ-opioid receptor agonist (Ki = 35.13 nM). More importantly, the dose for the sedative effect (ED50 = 9.29 mg kg-1) of maj-11a was significantly higher than its analgesic dose (ED50 = 0.392 mg kg-1), which made it a promising peripheral analgesic candidate compound with weak sedative side effects.

TETRAHYDRO ISOQUINOLINE DERIVATIVES, PREPARATION METHODS AND MEDICINAL USES THEREOF

A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as κ-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1, R2, R3, R4 of general formula (I) are defined as the description.

Tetrahydro isoquinoline derivatives, preparation methods and medicinal uses thereof

A kind of tetrahydro isoquinoline derivatives (I), their preparation methods, medicine compositions and medicinal uses thereof, especially their uses as kappa-opioid receptor excitant in pain relieving, which belongs to the medicine chemistry. The substituents R1, R2, R3, R4 of general formula (I) are defined as the description.