38177-33-2

Basic information

• Product Name: [4-(acetyloxy)phenyl]acetic acid
• CAS NO: 38177-33-2
• Molecular Formula: C₁₀H₁₀O₄
• Molecular Weight: 194.184
• Mol File: 38177-33-2.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 344.1°C at 760 mmHg
• Flash Point: 137.5°C
• Density: 1.256g/cm³
• Vapor Pressure: 2.57E-05mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: [4-(acetyloxy)phenyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [4-(acetyloxy)phenyl]acetic acid(38177-33-2)
• EPA Substance Registry System: [4-(acetyloxy)phenyl]acetic acid(38177-33-2)

Safety Data

• Hazardous Substances Data: 38177-33-2(Hazardous Substances Data)

Usage

General Description

[4-(acetyloxy)phenyl]acetic acid is a chemical compound with the molecular formula C10H10O4. It is a derivative of phenylacetic acid, in which the phenyl group is substituted at the 4-position with an acetyloxy group. [4-(acetyloxy)phenyl]acetic acid is a white crystalline solid that is insoluble in water but soluble in organic solvents. It is commonly used in the pharmaceutical industry as a precursor for the synthesis of various pharmaceuticals. It is also used as a building block in the synthesis of organic compounds and as a reagent in organic chemical reactions. Additionally, it has been studied for its potential medicinal properties, including anti-inflammatory and analgesic effects.

Upstream product

• 67741-16-6 O-acetyl-4-hydroxyphenylacetonitrile 
• 56401-28-6 [2-hydroxyimino-3-(4-hydroxyphenyl)]propionic acid 
• 79145-99-6 3-(4-hydroxy-phenyl)-2-thioxo-propionic acid 
• 1197-55-3 4-aminophenylacetic acid 
• 107-21-1 ethylene glycol 
• 156-38-7 4-hydroxyphenylacetate 
• 108-24-7 acetic anhydride 

Downstream Products

• 1217-32-9 2-(4-hydroxyphenyl)-1,3-indandione 
• 65448-20-6 4-acetoxyphenylacetyl chloride 
• 79524-45-1 19-(p-Hydroxyphenylacetoxy)-4-androstene-3,17-dione 
• 79524-44-0 19-(p-Acetoxyphenylacetoxy)-androstenedione 
• 85275-18-9 2-chloro-3-p-hydroxyphenylquinoline 
• 76210-09-8 3-(P-acetoxyphenylacetyl)-8-methoxy-2-methyl-1,2,4,5-tetrahydro-3H,3-benzazepine 
• 1327278-02-3 4-(((S)-4,5-dihydro-4-phenyloxazol-2-yl)methyl)phenyl acetate 
• 1327278-09-0 4-((S)-5,6-dihydro-2-oxo-5-phenyl-2H-1,4-oxazin-3-yl)phenyl acetate 
• 1327278-14-7 4-((3R,5S)-2-oxo-5-phenyl-morpholin-3-yl)phenyl acetate 
• 1327277-97-3 4-(((S)-2-hydroxy-1-phenylethylcarbamoyl)methyl)phenyl acetate 
• 22818-40-2 D-4-hydroxyphenylglycine 
• 37763-23-8 D-2-p-hydroxyphenylglycine methyl ester 
• 131179-73-2 4-<<<4-(trifluoromethyl)anilino>carbonyl>methyl>phenol 
• 914490-51-0 acetic acid 4-[(4-trifluoromethyl-phenylcarbamoyl)-methyl]-phenyl ester 

Relevant articles and documents

Hit-to-lead optimization of novel benzimidazole phenylacetamides as broad spectrum trypanosomacides

Trypanosoma cruzi and Trypanosoma brucei are the parasitic causative agents of Chagas disease and human African trypanosomiasis (HAT), respectively. The drugs currently used to treat these diseases are not efficacious against all stages and/or parasite sub-species, often displaying side effects. Herein, we report the SAR exploration of a novel hit, 2-(4-chlorophenyl)-N-(1-propyl-1H-benzimidazol-2-yl)acetamide previously identified from high throughput screens against T. cruzi, Trypanosoma brucei brucei and Leishmania donovani. An informative set of analogues was synthesized incorporating key modifications of the scaffold resulting in improved potency whilst the majority of compounds retained low cytotoxicity against H9c2 and HEK293 cell lines. The SAR observed against T. cruzi broadly matches that observed against T.b. brucei, suggesting the possibility for a broad-spectrum candidate. This class of compounds therefore warrants further investigation towards development as a treatment for Chagas disease and HAT. This journal is

QUINOLINE AND QUINOXALINE DERIVATIVES AS INHIBITORS OF KINASE ENZYMATIC ACTIVITY

Compounds of formula (IA) or (IB), are inhibitors of aurora kinase activity: Formula (IA), (IB) wherein -L1Y1-[CH2]z- is a linker radical wherein Y1, L1 and z are as defined in the claims; R6 is C1-C4alkoxy, hydrogen or halo; W represents a bond, -CH2-, -O-, -S-, -S(=O)2-, or -NR5- where R5 is hydrogen or C1-C4 alkyl; Q is =N-, =CH- or =C(X1)- wherein X1 is cyano, cyclopropyl or halo; linker radicals L2 are as defined in the claims; R is a radical of formula (X) or (Y): wherein R1 is a carboxylic acid group (-COOH), or an ester group which is hydrolysable by one or more intracellular carboxylesterase enzymes to a carboxylic acid group; R4 is hydrogen; or optionally substituted C1-C6 alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, heteroaryl(C1-C6 alkyl)-, -(C=O)R3, -(C=O)OR3, or -(C=O)NR3 wherein R3 is hydrogen or optionally substituted (C1-C6)alkyl, C3-C7 cycloalkyl, aryl, aryl(C1-C6 alkyl)-, heteroaryl, or heteroaryl(C1-C6 alkyl)-; R41 is hydrogen or optionally substituted C1-C6 alkyl; and D is a monocyclic heterocyclic ring of 5 or 6 ring atoms.

New cyclohexadienone derivatives: Preparation and chiral discrimination in high-pressure diels - Alder cycloadditions

A wide range of cyclohexadienones has been synthesised in order to study their reactivity and their regio- and stereoselectivity with the enantiopure diene 1 under high-pressure conditions. Computational investigations were used to point out some paramete