38199-92-7Relevant academic research and scientific papers
Catalytic Enantioselective [10+4] Cycloadditions
Donslund, Bjarke S.,Jessen, Nicolaj Inunnguaq,Bertuzzi, Giulio,Giardinetti, Maxime,Palazzo, Teresa A.,Christensen, Mette Louise,J?rgensen, Karl Anker
supporting information, p. 13182 - 13186 (2018/09/12)
The first peri- and stereoselective [10+4] cycloaddition between catalytically generated amino isobenzofulvenes and electron-deficient dienes is described. The highly stereoselective catalytic [10+4] cycloaddition exhibits a broad scope with high yields,
Palladium-Catalyzed Formal [4 + 1] Annulation via Metal Carbene Migratory Insertion and C(sp2)-H Bond Functionalization
Xu, Shuai,Chen, Ri,Fu, Zihao,Zhou, Qi,Zhang, Yan,Wang, Jianbo
, p. 1993 - 1997 (2017/08/14)
A highly efficient and operationally simple palladium-catalyzed formal [4 + 1] annulation reaction has been developed. The reaction is featured by the formation of two different C-C bonds on a carbenic center. It represents a concise method for the synthesis of a wide range of polycyclic aromatic hydrocarbons (PAHs) and 1H-indenes with easily available (trimethylsilyl)diazomethane as the carbene source. Metal carbene migratory insertion and C(sp2)-H bond activation are proposed as the key steps in this transformation. The reaction further demonstrates the versatility of the carbene-based coupling in combination with various transition-metal-catalyzed transformations.
Rhodium(II)- or Copper(I)-Catalyzed Formal Intramolecular Carbene Insertion into Vinylic C(sp2)?H Bonds: Access to Substituted 1H-Indenes
Zhou, Qi,Li, Shichao,Zhang, Yan,Wang, Jianbo
, p. 16013 - 16017 (2017/11/27)
A rhodium(II)- or copper(I)-catalyzed formal intramolecular carbene insertion into vinylic C(sp2)?H bonds is reported herein. This method provides straightforward access to 1H-indenes with high efficiency and excellent functional-group compatibility. Mechanistically, the reaction is proposed to involve the following sequence: metal carbene formation, intramolecular nucleophilic addition of the double bond to the electron-deficient carbene carbon atom, dearomatization, and finally a 1,5-H shift.
Palladium-catalysed direct cross-coupling of secondary alkyllithium reagents
Vila, Carlos,Giannerini, Massimo,Hornillos, Valentin,Fananas-Mastral, Martin,Feringa, Ben L.
, p. 1361 - 1367 (2014/03/21)
Palladium-catalysed cross-coupling of secondary C(sp3) organometallic reagents has been a long-standing challenge in organic synthesis, due to the problems associated with undesired isomerisation or the formation of reduction products. Based on our recently developed catalytic C-C bond formation with organolithium reagents, herein we present a Pd-catalysed cross-coupling of secondary alkyllithium reagents with aryl and alkenyl bromides. The reaction proceeds at room temperature and on short timescales with high selectivity and yields. This methodology is also applicable to hindered aryl bromides, which are a major challenge in the field of metal catalysed cross-coupling reactions.
Synthesis of substituted 4-aroyl-1-indanone and 5-aroyl-1-tetralone
Chang, Meng-Yang,Lee, Nien-Chia
, p. 306 - 308 (2011/10/19)
Several substituted 4-aroyl-1-indanones 2 and 5-aroyl-1-tetralones 3 were prepared in good yields from 1-indanones 1 via a series of reasonable transformations.
Dications of 3-phenyl-indenylidene dibenzo[ a. d ]cycloheptene: The role of charge in the antiaromaticity of cationic systems
Mills, Nancy S.,Cheng, Francine E.,Baylan, Joseph M.,Tirla, Cornelia,Hartmann, Jennifer L.,Patel, Kiran C.,Dahl, Bart J.,McClintock, Sean P.
experimental part, p. 645 - 653 (2011/03/19)
Dications of 9-(3-phenyl-1H-inden-1-ylidene)-5H-dibenzo[a,d]cycloheptene, 52+, were prepared by oxidation with SbF5 in SO 2ClF, and their magnetic behavior was compared to dications of 9-(3-phenyl-1H-inden-1-ylidene)-9H-fl
Dications of 3-phenylindenylidenefluorenes: Evaluation of antiaromaticity of indenyl and fluorenyl cations by magnetic measures
Mills, Nancy S.,Llagostera, Kathleen B.,Tirla, Cornelia,Gordon, Stacey M.,Carpenetti, Donald
, p. 7940 - 7946 (2007/10/03)
Dications of p-substituted 3-phenylindenylidenefluorenes were prepared to examine the response of the resulting indenyl and fluorenyl cationic systems to magnetic measures of antiaromaticity. All measures, 1H NMR shifts, nucleus independent che
BIPHENYL INTEGRIN ANTAGONISTS
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Page/Page column 35-36, (2010/11/08)
The following invention is directed to pharmaceutical compounds and compositions of the Formula (I). useful for treating conditions mediated by αVβ3 and/or αVβ5 integrin.
The effect of meta- and para-methoxy substitution on the reactivity of the radical cations of arylalkenes and alkanes. Radical ions in photochemistry. Part 26
Arnold, Donald R.,Du, Xinyao,Henseleit, Kerstin M.
, p. 839 - 852 (2007/10/02)
The effect of meta- and para-methoxy substitution on the reactivity of some radical cations has been determined.The compounds chosen for study were 1-(3-methoxyphenyl)-1-phenylethylene (7), 1-(4-methoxyphenyl)-1-phenylethylene (8), 3-(3-methoxyphenyl)inde
Response of Acidity and Magnetic Rtesonance Properties to Aryl Substitution in Carbon Acids and Derived Carbanions: 2- and 3-Arylindenes
Greifenstein, Linda G.,Lambert, Joseph B.,Nienhuis, Ronald J.,Fried, Herbert E.,Pagani, Giorgio A.
, p. 5125 - 5132 (2007/10/02)
Substitution in the aryl ring of 2- and 3-arylindenes has been used to examine the acidity of these hydrocarbons and the charge density and ion pair structure of their anions.Acidities were measured for the 2-arylindenes both in pure Me2SO and in Me2SO-H2
