38215-64-4Relevant academic research and scientific papers
Synthesis, physical-chemical characterisation and biological evaluation of novel 2-amido-3-hydroxypyridin-4(1H)-ones: Iron chelators with the potential for treating Alzheimer's disease
Gaeta, Alessandra,Molina-Holgado, Francisco,Kong, Xiao L.,Salvage, Sarah,Fakih, Sarah,Francis, Paul T.,Williams, Robert J.,Hider, Robert C.
experimental part, p. 1285 - 1297 (2011/03/23)
A novel class of 2-amido-3-hydroxypyridin-4-one iron chelators is described. These compounds have been designed to behave as suitable molecular probes which will improve our knowledge of the role of iron in neurodegenerative conditions. Neurodegenerative disorders, such as Alzheimer's disease (AD) and Parkinson disease (PD), can be considered as diverse pathological conditions sharing critical metabolic processes such as protein aggregation and oxidative stress. Interestingly, both these metabolic alterations seem to be associated with the involvement of metal ions, including iron. Iron chelation is therefore a potential therapeutic approach. The physico-chemical (pKa, pFe 3+ and log P) and biological properties (inhibition of iron-containing enzymes) of these chelators have been investigated in order to obtain a suitable profile for the treatment of neurodegenerative conditions. Studies with neuronal cell cultures confirm that the new iron chelators are neuroprotective against β-amyloid-induced toxicity.
IRON MODULATORS
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Page/Page column 14; Figure 3, (2010/11/24)
Iron modulator compounds of formula (I) are provided for treating amyloidoses wherein R1 is selected from H, C1-6 alkyl, C1-6 alkenyl, C1-6 hydroxyalkyl, C1-6 hydroxyalkenyl, R2 is selected from H, C1-6 alkyl, C1-6 alkenyl, C1-6 hydroxyalkyl, C1-6 hydroxyalkenyl and C6-10 aralykyl in which the aryl group of the aralkyl group is optionally substituted by hydroxy, halo or C1-4 alkyl R3 is selected from H, C1-6 alkyl, C1-6 alkenyl and C1-12 acyl; R4 is selected from H and C1-3 alkyl R5, R6 and R7 are independently selected from H, C1-6 alkyl, C3-7 aryl, and C1-10 aralkyl; the alkyl, aryl and aralkyl groups being optionally substituted by one or more halo, hydroxy and nitro groups or R5 and R7 together with the nitrogen atom to which they are bonded form a heterocyclic ring optionally substituted by one or more hydroxyl groups or a pharmaceutically acceptable tautomer, ester or addition salt thereof.
Electron transfer-initiated asymmetric photocyclization of chiral auxiliary-substituted N-acyl-α-dehydro(1-naphthyl)alaninamides to the corresponding 3,4-dihydrobenzo[f]quinolinone derivatives
Maekawa, Kei,Kubo, Kanji,Igarashi, Tetsutaro,Sakurai, Tadamitsu
, p. 11211 - 11224 (2007/10/03)
Photoinduced electron transfer reactions of the title N-acyl-α- dehydronaphthylalaninamides [(Z)-1] with (S)-1-phenylethylamino and (S)-alaninamide auxiliary groups in methanol containing a tertiary amine were shown to form (R,S)- and (S,S)-3,4-dihydroben
OPTICAL ACTIVITY OF LACTONES AND LACTAMS-IV CHIROPTICAL PROPERTIES OF 4-IMIDAZOLIDINONES
Polonski, T.
, p. 611 - 616 (2007/10/02)
The chiroptical properties of 4-imidazolidinones are reviewed.Several optically active compounds were obtained from amides and N-methylamides of corresponding N-acylamino acids.The origin of the two lowest energy electronic transitions is considered.The e
Aqueous Solutions Containing Amino Acids and Peptides. Part 16. --Solute-Solute Interactions in Solutions Containing some N-Acetyl-N'-methylamino Acid Amides
Blackburn, G. Michael,Lilley, Terence H.,Milburn, Peter J.
, p. 2191 - 2206 (2007/10/02)
The energetics of the interactions occuring between some N-acetyl-N'-methylamino acid amides in aqueous solutions at 25 deg C have been investigated.Osmotic coefficients and enthalpies of dilution have been obtained for single-component and two-component
