38228-99-8

Usage

Uses

Used in Rubber Industry:
N,N'-Dibenzylphthalamide is used as a primary antioxidant and heat stabilizer for the production of natural and synthetic rubbers, such as in the manufacturing of tires and other rubber products. It helps to prevent the degradation of rubber materials at high temperatures, ensuring the durability and performance of rubber products.
Used in Plastic Industry:
N,N'-Dibenzylphthalamide is used as a plasticizer in the production of PVC materials, improving the flexibility and workability of the plastic.
Used in Pharmaceutical Industry:
N,N'-Dibenzylphthalamide serves as an intermediate in the synthesis of pharmaceuticals and organic compounds, contributing to the development of new drugs and medicinal products.
However, it is important to note that DBZP may have potential health hazards and environmental impacts. Therefore, proper handling and safety precautions should be taken during its production and use to minimize any adverse effects.

Upstream product

• 1875-48-5 N-aminophthalamide 
• 100-46-9 benzylamine 
• 88-99-3 benzene-1,2-dicarboxylic acid 
• 32387-10-3 2-[(furan-2-ylmethylidene)amino]-1H-isoindole-1,3(2H)-dione 
• 34403-64-0 N-(p-chlorobenzylideneamino)phthalimide 
• 34403-62-8 N-(o-chlorobenzylideneamino)phthalimide 
• 524-38-9 N-hydroxyphthalimide 
• 1914-20-1 N-methoxyphthalimide 
• 601-70-7 3,3-dichlorophthalide 
• 7554-84-9 β-naptalam 
• 67-64-1 acetone 
• 85-44-9 phthalic anhydride 
• 612-14-6 phthalyl alcohol 
• 136918-14-4 phthalimide 

Relevant academic research and scientific papers

Guanidine cyclic diimides and their polymers

We report the formation and degradation of a unique guanidine cyclic diimide (GCDI) structure and GCDI-based polymers. The GCDI structure is readily formed under mild conditions. The X-ray crystal structure showed that the delocalized π-orbitals in the guanidine plane are significantly disrupted in the GCDI structure. Unlike amine-based imides, the GCDI structure readily degrades into the initial guanidine in protic solvents at ambient temperatures. Furthermore, poly(GCDI)s, a new category of polymers with the GCDI backbones, can be synthesized from guanidines and dianhydrides. Similar to the monomeric GCDIs, poly(GCDI)s are degraded in protic solvents unlike polyimides with high chemical stability.

MANGANESE BASED COMPLEXES AND USES THEREOF FOR HOMOGENEOUS CATALYSIS

The present invention relates to novel manganese complexes and their use, inter alia, for homogeneous catalysis in (1) the preparation of imine by dehydrogenative coupling of an alcohol and amine; (2) C-C coupling in Michael addition reaction using nitriles as Michael donors; (3) dehydrogenative coupling of alcohols to give esters and hydrogen gas (4) hydrogenation of esters to form alcohols (including hydrogenation of cyclic esters (lactones) or cyclic di-esters (di- lactones), or polyesters); (5) hydrogenation of amides (including cyclic dipeptides, lactams, diamide, polypeptides and polyamides) to alcohols and amines (or diamine); (6) hydrogenation of organic carbonates (including polycarbonates) to alcohols or hydrogenation of carbamates (including polycarbamates) or urea derivatives to alcohols and amines; (7) dehydrogenation of secondary alcohols to ketones; (8) amidation of esters (i.e., synthesis of amides from esters and amines); (9) acylation of alcohols using esters; (10) coupling of alcohols with water and a base to form carboxylic acids; and (11) preparation of amino acids or their salts by coupling of amino alcohols with water and a base. (12) preparation of amides (including formamides, cyclic dipeptides, diamide, lactams, polypeptides and polyamides) by dehydrogenative coupling of alcohols and amines; (13) preparation of imides from diols.

A phthalimidation protocol that follows protein defined parameters

This work outlines the first phthalimidation protocol suitable for protein labeling and performed in aqueous media at room temperature and neutral pH with no catalyst or co-reagent required. The methodology is suitable for a range of amines and its efficiency was determined with chemoselective and site-selective protein labeling. This journal is

Design, synthesis and structure-activity relationship studies of morpholino-1H-phenalene derivatives that antagonize Mcl-1/Bcl-2

We report herein characteristic studies of Mcl-1 and Bcl-2 dual inhibitors. It was found that a protruding carbonyl group forming hydrogen bond with R263 plays a predominant role compared with the hydrophobic group that occupies the p2 pocket. A series of dual inhibitors representing different parts of the morpholino-1H-phenalene were designed, synthesized and evaluated.

Studies on the Lossen-type rearrangement of N-(3-phenylpropionyloxy) phthalimide and N-tosyloxy derivatives with several nucleophiles

The reaction of N-(3-phenylpropionyloxy)phthalimide (1a) and N-tosyloxy (5a,b) derivatives with nucleophiles was examined and found to give the products via Lossen-type rearrangement. In order to obtain the scope of this reaction mechanism, further studies the reaction of several N-sulfonyloxyimide derivatives with various nucleophiles under similar conditions were carried out and found to afford the corresponding same types of products in high yields.

The reaction of phthalidylidene dichloride with primary amines. Synthesis and X-ray molecular structure of N-substituted phthalisoimides

An efficient method for the synthesis of N-substituted phthalisoimides, by reaction of phthalidylidene dichloride with primary amines, is described. The reactions with arylamines, arylenediamincs and alkylenediamines lead to the corresponding phthalisoimides or bisphthalisoimides in nearly quantitative yields. However, the reactions with alkylamines are not useful because of the relatively high nucleophilicity of alkylamines. Certain particular behaviours of arylamines, associated with the presence of specific ortho-substituents have been found. The reactions of arylamines bearing an o-hydroxymethyl group provide a convenient method for preparing 2-benzoxazinylbenzoic acids. The X-ray crystallographic structures of N-(2-methoxyphenyl)phthalisoimide 3a and 2-(4H-3.1-benzoxazin-2-yl)benzoic acid 15a have been determined.

Nucleophilic reactions of N-hydroxy-,methoxy-,2,3-epoxypropoxy-phthalimides

Reaction of N-hydroxyphthalimide (4) with equivalent amounts of aliphatic and aromatic primary amines gives the N-substituted phthalimides (7), while with excess of these amines if gives the diamides (8) of phthalic acid.The reaction of 4 with t-butyl amine gives only the butyl monoamide (9a) of phthaloylhydroxamic acid.N-Methoxyphthalimide (5) reacts in the same manner.Compound 4 does not condense with epichlorohydrin, but condense with epibromohydrin to give N-(2,3-epoxypropoxy)phthalimide (6) which on reaction with equivalent amounts of aliphatic primary amines gives the N-substituted phthalimides (7) and with excess of the amines it gives the diamides (8) of phthalic acid.The reaction of 6 with aromatic primary amines gives only the N-arylphthalimides.Secondary amines do not react with 6.

Synthesis and some reactions of 3,4-dimethoxyphenylmethyleneaminophthalimide

3,4-Dimethoxyphenylmethyleneaminophthalimide (1) reacts with aromatic hydrocarbons under Friedel-Craft's conditions to give 4-arylphthalazin-1-ones (2a-c).The reaction involves ring cleavage followed by cyclization and elimination of the aldehyde moiety.The investigation is extended to study the reaction of the title compound with Grignard reagents and amines leading to the formation of 2a, 4-6), respectively.

SOME REACTIONS OF 6-CHLORO-2-METHYL-4H-1-BENZOPYRAN-4-ONE. PART II

6-Chloro-2-methyl-4H-1-benzopyran-4-one (I) gave the isoxazole derivative IIa on reaction with hydroxylamine hydrochloride. The action of hydrazine and phenylhydrazine on I resulted in pyrazole dervatives IIIa and IIIb, respectively. The reactivity of I with ethyloxalate and aromatic nitroso compounds have been investigated. Phthalide VIIIa derived from the chromone I was synthesised and rearranged easily into phthalone IX upon refluxing with alcoholic sodium methoxide. Cleavage of VIIIa with amines and hydrazine hydrate was studied. Thiation of phthalide VIIIa with either Lawesson's reagent or phosphorous pentasulphide yielded the corresponding thione VIIIe.

Action of Grignard Reagents and Amines on Some N-(Arylmethyleneamino)phthalimides

N-(Arylmethyleneamino)phthalimides (2a-c) carrying an o-substituent in the aryl group were prepared by the reaction of N-aminophthalimide with o-substituted benzaldehydes.The reaction of these compounds with Grignard reagents proceeded either by normal addition to one of the carbonyl groups to give 3a-c or by addition and cleavage to give 4-arylphthalaz-1-ones 5a-c.The steric effect exhibited by either the Grignard reagent or the N-arylmethylene compound was studied.The reaction of N-furfurylideneaminophthalimide (2d) with Grignard reagents was also investigated.N-( Arylmethyleneamino)phthalimides reacted with primary amines to give N,N'-dialkylphthalamides (7a and b) while the reaction with secondary amines gave (8a and b).