38257-95-3

Upstream product

• 629-11-8 1,6-hexanediol 
• 76-83-5 trityl chloride 
• 141561-63-9 (((3-methylbut-2-en-1-yl)oxy)methanetrityl)tribenzene 
• 74500-56-4 1,4-pentanediol monotrityl ether 
• 804556-25-0 6-trityloxyhexanal 
• 312493-51-9 (((4-methoxybenzyl)oxy)methanetriyl)tribenzene 

Downstream Products

• 82777-69-3 Methanesulfonic acid 6-trityloxy-hexyl ester 
• 804556-25-0 6-trityloxyhexanal 
• 158576-27-3 1-iodo-6-triphenylmethyloxyhexane 
• 213767-49-8 methyl 3-O-allyl-2-O-[2',3',4'-tri-O-benzyl-6'-O-(6''-trityloxyhexyl)-α-D-galactopyranosyl]-4-O-benzyl-6-O-methanesulfonyl-α-D-mannopyranoside 
• 213768-27-5 (1S,3R,4R,5S,6S,7R,18R,20S,21S,22R)-4,5,6,22-Tetrakis-benzyloxy-21-((2R,3R,5R,6R)-3,5-bis-benzyloxy-6-methyl-tetrahydro-pyran-2-yloxy)-20-methoxy-2,9,16,19,23-pentaoxa-tricyclo[16.2.2.1^3,7]tricosane 
• 213767-70-5 methyl 3-O-allyl-2-O-[2',3',4'-tri-O-benzyl-6'-O-(6''-hydroxyhexyl)-α-D-galactopyranosyl]-4-O-benzyl-6-O-methanesulfonyl-α-D-mannopyranoside 
• 213767-87-4 methyl 2-O-(3'-O-allyl-4'-O-benzyl-α-D-galactopyranosyl)-2,3,4-tri-O-benzyl-6,6'-di-O-(hexane-1,6-diyl)-α-D-mannopyranoside 
• 213768-08-2 methyl 2-O-(2',3',4'-tri-O-benzyl-α-D-galactopyranosyl)-4-O-benzyl-6,6'-di-O-(hexane-1,6-diyl)-α-D-mannopyranoside 
• 213766-20-2 ethyl 2,3,4-tri-O-benzyl-6-O-(6'-trityloxyhexyl)-1-thio-α-D-galactopyranoside 
• 220129-97-5 6-(trityloxy)hexanoic acid 

Relevant academic research and scientific papers

Large scale monotritylations of water soluble compounds containing multiple hydroxyl groups

A procedure for the large scale monotritylation of watersoluble substrates containing multiple hydroxylgroups is reported; no elaborate purification procedures are required.

Design, Synthesis and Structural Analysis of Glucocerebrosidase Imaging Agents

Gaucher disease (GD) is a lysosomal storage disorder caused by inherited deficiencies in β-glucocerebrosidase (GBA). Current treatments require rapid disease diagnosis and a means of monitoring therapeutic efficacy, both of which may be supported by the u

A new class of organogelators based on triphenylmethyl derivatives of primary alcohols: Hydrophobic interactions alone can mediate gelation

In the present work, we have explored the use of the triphenylmethyl group, a commonly used protecting group for primary alcohols as a gelling structural component in the design of molecular gelators. We synthesized a small library of triphenylmethyl deri

Indium-mediated cleavage of the trityl group from protected alcohols and diols

The reaction of primary, secondary, allylic and benzylic trityl ethers with indium powder in MeOH/NH4Cl led to reductive cleavage of the trityl-oxygen bond, affording the corresponding alcohols in good to excellent yield under very mild reaction conditions. The detritylation process could successfully be extended to mono and detritylated diols. This methodology represents a new and efficient detritylation procedure under mild reaction conditions.

Influence of the spacer length on the phase behaviors of mesogen-jacketed liquid crystalline polymers with a bulk side-chain

A series of mesogen-jacketed liquid-crystalline polymers (MJLCPs) containing two triphenylmethyl (Tr) units in the side chains, named poly{2,5-bis[(triphenylmethoxy-alkyl)oxycarbonyl]-styrenes} (denoted as Pv-m-Tr, m = 2, 4, 6, 8, 10, 12, which is the num

Chemoselective reduction of aldehydes over ketones with sodium tris(hexafluoroisopropoxy)borohydride

Chemoselective reduction of aldehydes in the presence of ketones was achieved using sodium tris(hexafluoroisopropoxy)borohydride which can be stored as a THF solution. Georg Thieme Verlag Stuttgart.

Alternative reagents for the tritylation of alcohols

Two new tritylation reagents [viz. p-methoxybenzyl trityl ether (p-MBTE) and prenyl trityl ether (PTE)] were prepared. These two new reagents were utilized efficiently for the tritylation of alcohols, using DDQ or 20 mol% DDQ-3 eq. Mn(OAc)3. Copyright Tay

N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors

Novel N1-substituted thymine derivatives related to 1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine have been synthesized and evaluated against thymidine kinase-2 (TK-2) and related nucleoside kinases [i.e., Drosophila melanogaster deoxynucleosid

Efficient chemoselective deprotection of silyl ethers using catalytic 1-chloroethyl chloroformate in methanol

Fast and chemoselective desilylation of silyl-protected alcohols was achieved using a catalytic amount of 1-chloroethyl chloroformate in methanol. With a minimal amount of 1-chloroethyl chloroformate as the source for anhydrous HCl, extremely efficient cleavage of silyl ethers of primary and secondary alcohols was accomplished, and chemoselective deprotection of one silyl ether in the presence of another silyl or other acid-labile group was possible through controlling the amount of the chloroformate and reaction time.

New Antibacterial Agents Derived from the DNA Gyrase Inhibitor Cyclothialidine

Cyclothialidine (1, Ro 09-1437) is a potent DNA gyrase inhibitor that was isolated from Streptomyces filipinensis NR0484 and is a member of a new family of natural products. It acts by competitively inhibiting the ATPase activity exerted by the B subunit of DNA gyrase but barely exhibits any growth inhibitory activity against intact bacterial cells, presumably due to insufficient permeation of the cytoplasmic membrane. To explore the antibacterial potential of 1, we developed a flexible synthetic route allowing for the systematic modification of its structure. From a first set of analogues, structure-activity relationships (SAR) were established for different substitution patterns, and the 14-hydroxylated, bicyclic core (X) of 1 seemed to be the structural prerequisite for DNA gyrase inhibitory activity. The variation of the lactone ring size, however, revealed that activity can be found among 11- to 16-membered lactones, and even seco-analogues were shown to maintain some enzyme inhibitory properties, thereby reducing the minimal structural requirements to a rather simple, hydroxylated benzyl sulfide (XI). On the basis of these "minimal structures" a modification program afforded a number of inhibitors that showed in vitro activity against Gram-positive bacteria. The best activities were displayed by 14-membered lactones, and representatives of this subclass exhibit excellent and broad in vitro antibacterial activity against Gram-positive pathogens, including Staphylococcus aureus, Streptococcus pyogenes, and Enterococcus faecalis, and overcome resistance against clinically used drugs. By improving the pharmacokinetic properties of the most active compounds (94, 97), in particular by lowering their lipophilic properties, we were able to identify congeners of cyclothialidine (1) that showed efficacy in vivo.