4961-40-4

Basic information

• Product Name: TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE
• Synonyms: 2-ethanediamine,n,n’-bis(2-aminoethyl)-tetrahydrochloride;n,n’-bis(2-aminoethyl)-1,2-ethanediaminetetrahydrochloride;trientinetetrahydrochloride;TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE;3,6-diazaoctane-1,8-diamine tetrahydrochloride;Triethylenetetramine4HCl;1,4,7,10-Tetraazadecane tetrahydrochloride;Triethylenetetramine·4hydrochloride
• CAS NO: 4961-40-4
• Molecular Formula: C₆H₂₂N₄*4Cl
• Molecular Weight: 292.08
• EINECS: 225-604-3
• Product Categories: Amine Salts;Nitrogen Compounds;Organic Building Blocks
• Mol File: 4961-40-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 269-270 °C(lit.)
• Boiling Point: 344.6°Cat760mmHg
• Flash Point: 162.2°C
• Appearance: /
• Density: 1.49g/cm³
• Vapor Pressure: 0.00861mmHg at 25°C
• CAS DataBase Reference: TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE(4961-40-4)
• EPA Substance Registry System: TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE(4961-40-4)

Safety Data

• Hazard Codes: Xn
• Statements: 36/37/38-40
• Safety Statements: 22-26-36
• WGK Germany: 3
• RTECS: KH8587087
• Hazardous Substances Data: 4961-40-4(Hazardous Substances Data)

Usage

Chemical Properties

beige powder or chunks

Uses

Triethylenetetramine tetrahydrochloride was used as primary amine displacer in affinity chromatography.

General Description

Triethylenetetramine tetrahydrochloride is a copper-chelating agent

Biochem/physiol Actions

Triethylenetetramine tetrahydrochloride induces apoptosis of acinar cells of the pancreas in male Fischer 344 rats.

InChI:InChI=1/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2/p+4

Upstream product

• 112-24-3 triethylentetramine 
• 206531-21-7 tert-butyl N-(2-aminoethyl)-N-[2-(2-aminoethyl(tert-butoxycarbonyl)amino)ethyl]carbamate 
• 876954-32-4 2-[3-(2-amino-ethyl)-2-phenylimidazolidin-1-yl]-ethylamine 
• 81904-67-8 1,3-bis-(2-benzylidenamino-ethyl)-2-phenyl-imidazolidine 

Downstream Products

• 112-24-3 triethylentetramine 
• 38260-01-4 N,N'-bis(2-aminoethyl)ethane-1,2-diamine dihydrochloride 
• 65294-33-9 6A-{{2-{{2-[(2-aminoethyl)amino]ethyl}amino}ethyl}amino}-6A-deoxy-β-cyclodextrin 

Relevant articles and documents

CRYSTALLINE FORM OF TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE AND ITS PHARMACEUTICAL USE

The present invention describes a new crystalline form of triethylenetetramine tetrachloride which has improved room temperature stability over known forms and over the dichloride salt. The new crystalline form is characterised by having peaks in an XRPD spectrum at 22.9, 25.4, 25.8, 26.6, 34.6 and 35.3 ± 0.1°2Θ and Raman shifts 943, 1173, 1527 and 1612 ± 5 cm-1. The crystalline form of triethylenetetramine tetrachloride is useful in the treatment of Wilson's disease. Also disclosed is a method for preparing a crystalline form of triethylenetetramine tetrachloride comprising the addition of an anti- solvent to an aqueous solution of the compound.