4961-40-4

Usage

Uses

Used in Affinity Chromatography:
Triethylenetetramine tetrahydrochloride is used as a primary amine displacer in affinity chromatography. Affinity chromatography is a technique used to separate and purify specific molecules, such as proteins, based on their interactions with a specific ligand or target molecule. In this application, triethylenetetramine tetrahydrochloride serves to displace primary amines from their binding sites on the affinity matrix, allowing for the selective elution of the target molecule.
In the biotechnology and pharmaceutical industries, affinity chromatography is a valuable tool for the purification of proteins, enzymes, and other biomolecules. The use of triethylenetetramine tetrahydrochloride as a primary amine displacer enhances the efficiency and selectivity of the purification process, making it a useful component in the development and optimization of affinity chromatography systems.

Biochem/physiol Actions

Triethylenetetramine tetrahydrochloride induces apoptosis of acinar cells of the pancreas in male Fischer 344 rats.

InChI:InChI=1/C6H18N4/c7-1-3-9-5-6-10-4-2-8/h9-10H,1-8H2/p+4

Upstream product

• 112-24-3 triethylentetramine 
• 206531-21-7 tert-butyl N-(2-aminoethyl)-N-[2-(2-aminoethyl(tert-butoxycarbonyl)amino)ethyl]carbamate 
• 876954-32-4 2-[3-(2-amino-ethyl)-2-phenylimidazolidin-1-yl]-ethylamine 
• 81904-67-8 1,3-bis-(2-benzylidenamino-ethyl)-2-phenyl-imidazolidine 

Downstream Products

• 112-24-3 triethylentetramine 
• 38260-01-4 N,N'-bis(2-aminoethyl)ethane-1,2-diamine dihydrochloride 
• 65294-33-9 6A-{{2-{{2-[(2-aminoethyl)amino]ethyl}amino}ethyl}amino}-6A-deoxy-β-cyclodextrin 

Relevant academic research and scientific papers

CRYSTALLINE FORM OF TRIETHYLENETETRAMINE TETRAHYDROCHLORIDE AND ITS PHARMACEUTICAL USE

The present invention describes a new crystalline form of triethylenetetramine tetrachloride which has improved room temperature stability over known forms and over the dichloride salt. The new crystalline form is characterised by having peaks in an XRPD spectrum at 22.9, 25.4, 25.8, 26.6, 34.6 and 35.3 ± 0.1°2Θ and Raman shifts 943, 1173, 1527 and 1612 ± 5 cm-1. The crystalline form of triethylenetetramine tetrachloride is useful in the treatment of Wilson's disease. Also disclosed is a method for preparing a crystalline form of triethylenetetramine tetrachloride comprising the addition of an anti- solvent to an aqueous solution of the compound.

Synthesis of triethylenetetramines

Methods and intermediates for synthesizing triethylenetetramine and salts thereof, as well as novel triethylenetetramine salts and their crystal structure, and triethylenetetramine salts of high purity.