38275-56-8

Basic information

• Product Name: 2-Pyrimidinecarbonitrile, 5-chloro- (9CI)
• Synonyms: 2-Pyrimidinecarbonitrile, 5-chloro- (9CI);5-chloropyrimidine-2-carbonitrile;5-CHLOROPYRIMIDINE-2-CARBONITRILE,PURITY:97% MIN(HPLC);2-Cyano-5-chloropyrimidine;5-Chloro-2-pyrimidinecarbonitrile;5-chloropyriMidine-2-carbonitril
• CAS NO: 38275-56-8
• Molecular Formula: C₅H₂ClN₃
• Molecular Weight: 139.54248
• Product Categories: PYRIMIDINE;Heterocycle-Pyrimidine series
• Mol File: 38275-56-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 78℃
• Boiling Point: 292℃
• Flash Point: 130℃
• Appearance: /
• Density: 1.43
• Vapor Pressure: 0.00189mmHg at 25°C
• Refractive Index: 1.568
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -4.65±0.22(Predicted)
• CAS DataBase Reference: 2-Pyrimidinecarbonitrile, 5-chloro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrimidinecarbonitrile, 5-chloro- (9CI)(38275-56-8)
• EPA Substance Registry System: 2-Pyrimidinecarbonitrile, 5-chloro- (9CI)(38275-56-8)

Safety Data

• Hazardous Substances Data: 38275-56-8(Hazardous Substances Data)

Usage

General Description

2-Pyrimidinecarbonitrile, 5-chloro- (9CI) is a chemical compound classified under the pyrimidine category. Pyrimidines are aromatic heterocyclic organic compounds similar to pyridine, with one carbon atom replaced by a nitrogen atom. 2-Pyrimidinecarbonitrile, 5-chloro- possess a chlorine atom along with a cyano group in its structure suggesting potential reactivity. Although there is limited specific information available regarding its physical properties or uses, as a derivative of pyrimidine, it may have potential use in a variety of applications including pharmaceuticals, agrochemicals, and other chemical research. 2-Pyrimidinecarbonitrile, 5-chloro- (9CI) also might be important for various analytical and synthetic purposes. However, health and environmental impacts should be adequately evaluated before use.

InChI:InChI=1/C5H2ClN3/c6-4-2-8-5(1-7)9-3-4/h2-3H

Upstream product

• 143-33-9 sodium cyanide 
• 38275-47-7 5-chloro-2-(methylsulfonyl)pyrimidine 
• 7677-24-9 trimethylsilyl cyanide 
• 114969-48-1 5-chloropyrimidine N-oxide 

Downstream Products

• 894797-00-3 5-chloropyrimidine-2-carboxylic acid methyl ester 
• 56621-93-3 5-aminopyrimidine-2-carbonitrile 

Relevant articles and documents

CYCLOALKYLAMINO ACID DERIVATIVES

The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R1, R2, R3, R4, R5, R8, m, n, p, q, r, s, t and u are as defined herein. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Studies on Pyrimidine Derivatives. XXXIX. Site-Selectivity in the Reaction of 5-Substituted and 4,5-Disubstituted Pyrimidine N-Oxides with Trimethylsilyl Cynanide

The site-selectivity in the modified Reissert-Henze reaction of 5-substituted and 4,5-disubstituted pyrimidine 1-oxides with trimethylsilyl cyanide was examined.The reaction of 5-substituted 4-methoxypyrimidine 1-oxides with trimethylsilyl cyanide gave exclusively 2-pyrimidinecarbonitriles in good yields without exception.On the other hand, the other 5-substituted and 4,5-disubstituted pyrimidine 1-oxides gave mainly 6-pyrimidinecarbonitriles.Keywords--site-selectivity; pyrimidine N-oxide; trimethylsilyl cyanide; Reissert-Henze reasction; pyrimidinecarbonitrile