38275-47-7

Usage

Uses

Used in Pharmaceutical Industry:
5-Chloro-2-(methylsulfonyl)pyrimidine is used as an intermediate in the synthesis of pharmaceuticals for its ability to contribute to the development of new drugs. Its unique structure allows it to be a key component in the creation of molecules with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical sector, 5-Chloro-2-(methylsulfonyl)pyrimidine is utilized as an intermediate in the synthesis of agrochemicals, playing a crucial role in the development of pesticides and other agricultural chemicals that are essential for crop protection and yield enhancement.
Used in Cancer Treatment Research:
5-Chloro-2-(methylsulfonyl)pyrimidine has been studied for its potential use in the treatment of cancer due to its demonstrated ability to inhibit the growth of certain cancer cell lines. It is explored as a possible therapeutic agent, contributing to advancements in oncology and cancer treatment options.

Upstream product

• 100-52-7 benzaldehyde 
• 38275-34-2 5-chloro-2-(methylsulfonyl)-4-pyrimidinecarboxylic acid 
• 38275-42-2 2-methylthio-5-chloropyrimidine 
• 61727-33-1 5-chloro-2-(methylthio)pyrimidine-4-carboxylic acid 

Downstream Products

• 38275-56-8 5-chloropyrimidine-2-carbonitrile 
• 1801862-02-1 3-chloro-2-[3-(difluoromethyl)isoxazol-5-yl]phenyl 5-chloropyrimidin-2-yl ether 
• 76660-32-7 2-(4-aminophenoxy)-5-chloropyrimidine 
• 69033-95-0 methyl 2-[2-(5-chloro-2-pyrimidyloxy)-4-chlorophenoxy] propionate 
• 69033-89-2 5-chloro-2-(4-methoxy-phenylsulfanyl)-pyrimidine 

Relevant academic research and scientific papers

PROCESS FOR SYNTHESIS OF A 2-THIOALKYL PYRIMIDINE

A method for preparing a compound of Formula 1 and compounds therefrom, comprising treating a compound of Formula 2 with a compound of Formula 3 and reacting the resulting intermediate of Formula 4 with a compound of Formula 5 (or a salt thereof). The compound of Formula 1, prepared by the above method, can be used to prepare a compound of Formula 8 wherein R2, R3, R4, m and r are as defined in the specification.

PROCESS FOR SYNTHESIS OF A 2-(5-ISOXAZOLYL)-PHENOL

A method for preparing a compound of Formula (1) and compounds therefrom, comprising treating a compound of Formula (2) to provide a compound of Formula (5) and treating the compound of Formula (5) with a hydroxylamine salt wherein R1, R2 and m are as defined in the specification. The compound of Formula (1), prepared by the above method, can be used to prepare a compound of Formula (8) wherein R1, R2, R3 and m are as defined in the specification.

INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL

The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

CYCLOALKYLAMINO ACID DERIVATIVES

The invention relates to compounds of formula I and to pharmaceutically acceptable salts, prodrugs, solvates or hydrates thereof; wherein B, D, E, R1, R2, R3, R4, R5, R8, m, n, p, q, r, s, t and u are as defined herein. This invention also relates to a method of using such compounds in the treatment of hyperproliferative diseases and autoimmune diseases in mammals, especially humans, and to pharmaceutical compositions containing such compounds.

Decarboxylation in the synthesis of 4-alkyl-, 4-alkenyl- and 4-acylpyrimidines

Decarboxylation of allylic esters of 4-carboxypyrimidines in toluene at 111°C in the presence of a Pd(0) catalyst, gives a mixture of a 4-alkenylpyrimidine and a pyrimidine unsubstituted in the 4-position. If the decarboxylation is carried out in the presence of benzaldehyde, then benzaldehyde is added to the 4-position. Decarboxylation of 4-carboxypyrimidines in the presence of different electrophiles, results in incorporation of the electrophile into the 4-position together with a pyrimidine unsubstituted in the 4-position. Use of microwave irradiation enhances the rate of the decarboxylations.

Efficient synthesis of a new pyrimidine derivative

A ready preparation for a new pyrimidine derivative, 2-aminomethyl-5-chloropyrimidine, from s-methylthiouronium sulphate and mucochloric acid is reported.

Pyrimidine-2-sulphides and their S-oxides for use in medicine and methods of use therefor, pharmaceutical compositions containing them, processes for their preparation and per se novel sulphides and S-oxides

Compounds of the formula STR1 (wherein X represents a halogen atom; n is 0, 1 or 2; R1 and R2, which may be the same or different, each represents a hydrogen atom or a carboxyl, esterified carboxyl, amido or mono- or di-C1-4 alkylamido group or a C1-4 alkyl group which may if desired carry a carboxyl or esterified carboxyl group; and R3 represents a C1-32 saturated or unsaturated, straight or branched, cyclic or acyclic aliphatic group or an araliphatic or heterocyclic substituted aliphatic group, a heterocyclic group or an aryl group which groups may if desired carry one or more substituents selected from halogen atoms and oxo, nitro, hydroxy, etherified hydroxy, esterified hydroxy, primary, secondary or tertiary amino, acylamino etherified mercapto or S=O or --SO2 derivatives thereof and esterified phosphonic acid groups) and, where an acidic or basic group is present, physiologically compatible salts thereof have been found to be of use in combating abnormal cell proliferation. The compounds are prepared inter alia by oxidation of the corresponding sulfide, displacement of a leaving atom or group from the 2-position of the pyrimidine by reaction with a sulfinic acid or by ring closure of the pyrimidine ring.