383-38-0

Usage

Uses

Used in Pharmaceutical Industry:
(4-FLUORO-BENZENESULFONYL)-ACETIC ACID is used as a building block for the synthesis of pharmaceuticals and agrochemicals. Its unique structural features, including the fluorine atom and sulfonyl group, make it a valuable component in the development of a wide range of organic compounds with potential applications in the medical field.
Used in Drug Development:
In the pharmaceutical industry, (4-FLUORO-BENZENESULFONYL)-ACETIC ACID is utilized as a key intermediate in the development of new drugs. Its reactivity and structural properties allow for the creation of novel drug candidates that can address various medical conditions and improve patient outcomes.
Used in Agrochemical Synthesis:
(4-FLUORO-BENZENESULFONYL)-ACETIC ACID also finds application in the agrochemical industry, where it serves as a building block for the synthesis of various agrochemical products. Its versatility in organic synthesis makes it a valuable asset in the development of new compounds for agricultural use, such as pesticides and herbicides.

Upstream product

• 79-11-8 chloroacetic acid 
• 1037147-97-9 ((4-fluorophenyl)sulfonyl)acetic acid ethyl ester 
• 78066-05-4 ethyl 2-(p-fluorophenylthiaoxy)acetate 
• 332-51-4 (4-fluorophenylthio)acetic acid 
• 371-42-6 4-Fluorothiophenol 

Downstream Products

• 102582-92-3 (4-Fluoro-benzenesulfonyl)-acetic acid; compound with 2-[bis-(2-hydroxy-ethyl)-amino]-ethanol 
• 66074-02-0 3,4-bis(4-fluorobenzene-1-sulfonyl)furoxan 
• 1412451-22-9 N-[cyclopropyl(phenyl)methyl]-2-[(4-fluorophenyl)sulfonyl]-N-(pyridin-2-ylmethyl)acetamide 
• 226396-71-0 2-(4-fluorobenzenesulfonyl)acetic acid methyl ester 
• 383-47-1 (4-fluoro-benzenesulfonyl)-acetic acid-(4-bromo-phenacyl ester) 

Relevant academic research and scientific papers

Modular Synthesis of Carbon-Substituted Furoxans via Radical Addition Pathway. Useful Tool for Transformation of Aliphatic Carboxylic Acids Based on "build-and-Scrap" Strategy

Utilizing radical chemistry, a new general C-C bond formation on the furoxan ring was developed. By taking advantage of the lability of furoxans, a wide variety of transformation of the synthesized furoxans have been demonstrated. Thus, this developed methodology enabled not only the modular synthesis of furoxans but also short-step transformations of carboxylic acids to a broad range of functional groups.

Mass spectra of arylsulphonylacetic acids and correlation of fragment ions with substituent constants

The mass spectral studies of arylsulphonylacetic acids reveal that the skeletal rearrangement via aryl-oxygen bond formation is predominant with a weak competing alkyl migration.A linear correlation is obtained between the intensities of + ions, i.e. +> and the Hammett substituent constants.

SYNTHESIS OF ORGANOSULFONYLACETIC ACID

Alkylsulfonylacetic acids and their esters were obtained by the alcoholysis of alkyl β,β-dichlorovinyl sulfones and the oxidation of alkylthioacetic acids.Arylsulfonylacetic acids were synthesized by the reaction of sodium arenesulfinates with monochloroacetic acid.The optimum conditions for the reaction were obtained.Arylsulfonylacetic esters were obtained by the reaction of monochloroacetic esters with sodium arenesulfinate in DMFA, and their hydrolysis led to the corresponding acids with yields of 65-98percent.Dichloroacetic estersreacts with arenesulfinates, forming di(arylsulfonyl)acetic esters.