383-38-0

Basic information

• Product Name: (4-FLUORO-BENZENESULFONYL)-ACETIC ACID
• Synonyms: ASINEX-REAG BAS 12738159;IFLAB-BB F2109-0036;(4-FLUORO-BENZENESULFONYL)-ACETIC ACID;AKOS BBS-00002848;RARECHEM AL BO 0774
• CAS NO: 383-38-0
• Molecular Formula: C₈H₇FO₄S
• Molecular Weight: 218.2
• Mol File: 383-38-0.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (4-FLUORO-BENZENESULFONYL)-ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUORO-BENZENESULFONYL)-ACETIC ACID(383-38-0)
• EPA Substance Registry System: (4-FLUORO-BENZENESULFONYL)-ACETIC ACID(383-38-0)

Safety Data

• Hazardous Substances Data: 383-38-0(Hazardous Substances Data)

Usage

General Description

(4-Fluoro-benzenesulfonyl)-acetic acid is a chemical compound with the molecular formula C8H7FO4S. It is a white to off-white crystalline powder with a molecular weight of 222.20 g/mol. (4-FLUORO-BENZENESULFONYL)-ACETIC ACID is often used as a building block in the synthesis of pharmaceuticals and agrochemicals. It contains a fluorine atom and a sulfonyl group, making it useful in the development of various organic compounds. Its acetic acid moiety also makes it readily reactive in organic synthesis. This chemical has potential applications in the pharmaceutical industry, particularly in the development of new drugs and pharmaceutical intermediates.

Upstream product

• 332-51-4 (4-fluorophenylthio)acetic acid 
• 1037147-97-9 ((4-fluorophenyl)sulfonyl)acetic acid ethyl ester 
• 78066-05-4 ethyl 2-(p-fluorophenylthiaoxy)acetate 
• 371-42-6 4-Fluorothiophenol 
• 79-11-8 chloroacetic acid 

Downstream Products

• 102582-92-3 (4-Fluoro-benzenesulfonyl)-acetic acid; compound with 2-[bis-(2-hydroxy-ethyl)-amino]-ethanol 
• 66074-02-0 3,4-bis(4-fluorobenzene-1-sulfonyl)furoxan 
• 1412451-22-9 N-[cyclopropyl(phenyl)methyl]-2-[(4-fluorophenyl)sulfonyl]-N-(pyridin-2-ylmethyl)acetamide 
• 226396-71-0 2-(4-fluorobenzenesulfonyl)acetic acid methyl ester 
• 383-47-1 (4-fluoro-benzenesulfonyl)-acetic acid-(4-bromo-phenacyl ester) 

Relevant articles and documents

Modular Synthesis of Carbon-Substituted Furoxans via Radical Addition Pathway. Useful Tool for Transformation of Aliphatic Carboxylic Acids Based on "build-and-Scrap" Strategy

Utilizing radical chemistry, a new general C-C bond formation on the furoxan ring was developed. By taking advantage of the lability of furoxans, a wide variety of transformation of the synthesized furoxans have been demonstrated. Thus, this developed methodology enabled not only the modular synthesis of furoxans but also short-step transformations of carboxylic acids to a broad range of functional groups.

SYNTHESIS OF ORGANOSULFONYLACETIC ACID

Alkylsulfonylacetic acids and their esters were obtained by the alcoholysis of alkyl β,β-dichlorovinyl sulfones and the oxidation of alkylthioacetic acids.Arylsulfonylacetic acids were synthesized by the reaction of sodium arenesulfinates with monochloroacetic acid.The optimum conditions for the reaction were obtained.Arylsulfonylacetic esters were obtained by the reaction of monochloroacetic esters with sodium arenesulfinate in DMFA, and their hydrolysis led to the corresponding acids with yields of 65-98percent.Dichloroacetic estersreacts with arenesulfinates, forming di(arylsulfonyl)acetic esters.