78066-05-4

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 371-42-6 4-Fluorothiophenol 
• 702-13-6 4-(isopropylthio)-1-fluorobenzene 
• 39794-75-7 ethyl α-p-toluenesulfonyloxyacetate 
• 405-31-2 bis(4-fluorophenyl)disulfide 
• 141-97-9 ethyl acetoacetate 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 332-51-4 (4-fluorophenylthio)acetic acid 
• 70932-09-1 2-(p-fluorophenylthiaoxy)acetyl chloride 
• 66074-02-0 3,4-bis(4-fluorobenzene-1-sulfonyl)furoxan 
• 383-38-0 p-fluorophenylsulphonylacetic acid 
• 1037147-97-9 ((4-fluorophenyl)sulfonyl)acetic acid ethyl ester 
• 36107-09-2 ((4-fluorophenyl)sulfonyl)acetohydrazide 
• 1246615-91-7 ethyl 2,2-difluoro-2-((4-fluorophenyl)thio)acetate 

Relevant academic research and scientific papers

Catalyst-free, visible-light-promoted S-H insertion reaction between thiols and α-diazoesters

A visible-light-promoted S-H insertion reaction between thiols and α-diazoesters was developed. The reaction proceeded smoothly at room temperature with a broad substrate scope, affording various thioethers in moderate to excellent yields. The catalyst- A

Design, synthesis and bioactivity evaluation of novel thioether derivatives containing a sulfonohydrazide moiety

A series of novel thioether derivatives containing a sulfonohydrazide moiety were synthesized and determined using 1H NMR, 13C NMR, HRMS, and elemental analysis. Their in vitro antibacterial activities against Xanthomonas oryzae pv.

Modular Synthesis of Carbon-Substituted Furoxans via Radical Addition Pathway. Useful Tool for Transformation of Aliphatic Carboxylic Acids Based on "build-and-Scrap" Strategy

Utilizing radical chemistry, a new general C-C bond formation on the furoxan ring was developed. By taking advantage of the lability of furoxans, a wide variety of transformation of the synthesized furoxans have been demonstrated. Thus, this developed methodology enabled not only the modular synthesis of furoxans but also short-step transformations of carboxylic acids to a broad range of functional groups.

Sulfonium ylide formation and subsequent C[sbnd]S bond cleavage of aromatic isopropyl sulfide catalyzed by hemin in aqueous solvent

Heme is an abundant and widely existed cofactor for a variety of metalloenzymes, whose broader use is generally impeded by its high instability and poor solubility. Here we report an environment-benign and efficient strategy for the sulfonium ylide formation and subsequent C[sbnd]S bond cleavage of aromatic isopropyl sulfides, which was catalyzed by hemin in assistance of Triton X-100. This aqueous catalytic system exhibited good functional group tolerance to a variety of sulfides and diazo esters. And the reaction mechanism was preliminarily proposed on the basis of designed reactions. Furthermore, the cleavage of C[sbnd]S bond followed by introducing a functional ester group to aromatic sulfides, may potentially be employed for the late stage functionalization (LSF) of organosulfur drug in the future.

Design, Synthesis, and Evaluation of New Sulfone Derivatives Containing a 1,3,4-Oxadiazole Moiety as Active Antibacterial Agents

This study aimed to synthesize some new sulfone derivatives containing a 1,3,4-oxadiazole moiety and investigate their in vitro antibacterial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Xanthomonas axonopodis pv. citri (Xac), the pathogens

2,5-substituent-1,3,4-oxadiazole sulfone derivative as well as preparation method and application thereof

The invention discloses a 2,5-substituent-1,3,4-oxadiazole sulfone derivative as well as a preparation method and application thereof. The 2,5-substituent-1,3,4-oxadiazole sulfone derivative has a general formula shown in a formula (I), wherein R1 is 4-chlorine or 4-fluorine; and R2 is methyl, ethyl, propyl, n-butyl, n-pentyl, benzyl, 4-chlorobenzyl or 4-fluorobenzyl. The 2,5-substituent-1,3,4-oxadiazole sulfone derivative disclosed by the invention has good activity on rice bacterial leaf blight and xanthomonas citri and is simple in structure, simple in preparation technology and low in production cost. (The formula (I) is described in the specification).

2. 5 - Substituted - 1, 3, 4 - oxadiazoles double-sulfones derivatives, preparation method and application thereof (by machine translation)

The invention discloses a 2, 5 - substituted - 1, 3, 4 - oxadiazoles double-sulfones derivatives, preparation method and application thereof, having formula (I) of the general formula, wherein: R1 For the 4 - chloro or 4 - fluoro; R2 For hydroxy, methyl, ethyl, benzyl, 4 - benzylic or 4 - fluorobenzyl. The invention relates to a rice BLB and citrus ulcer bacteria has better activity, the structure is simple, the preparation process is simple, the production cost is low. (by machine translation)

Sulfur-containing andrographolide derivative and pharmaceutical composition and synthesis method thereof and application of sulfur-containing andrographolide derivative in preparation of medicine for treating prostatic cancers

The invention relates to an andrographolide derivative shown in the following general formula (I) or general formula (II) (please see the formula in the description) and a preparation method thereof and a composition containing the compound shown in the g

Synthesis of thioether andrographolide derivatives and their inhibitory effect against cancer cells

A series of novel thioether andrographolide derivatives were synthesized by incorporating various aromatic (or heteroaromatic) substituents into C-12 or 14-OH. A total of 38 andrographolide derivatives were prepared and evaluated for their in vitro inhibi

Copper-Catalyzed Synthesis of α-Thioaryl Carbonyl Compounds Through S-S and C-C Bond Cleavage

A method to access α-thioaryl ketones and α-thioaryl esters employing copper acetate (hydrate) as catalyst and readily accessible diaryl disulfides and β-diketones (or β-keto esters) has been developed. Both alkyl- and aryl-substituted carbonyl compounds can be prepared. Copyright