332-51-4

Basic information

• Product Name: (4-FLUOROPHENYLTHIO)ACETIC ACID
• Synonyms: 2-(4-Fluorophenylthio)aceticacid97%;2-(p-Fluorophenylthio)acetic acid;RARECHEM AL BO 0775;(4-FLUOROPHENYLTHIO)ACETIC ACID;2-[(4-FLUOROPHENYL)THIO]ACETIC ACID;BUTTPARK 51\07-08;2-(4-Fluorophenylthio)acetic acid 97%
• CAS NO: 332-51-4
• Molecular Formula: C₈H₇FO₂S
• Molecular Weight: 186.2
• Mol File: 332-51-4.mol
• Article Data: 17

Chemical Properties

• Melting Point: 76-79°C
• Boiling Point: 315.4 °C at 760 mmHg
• Flash Point: 144.5 °C
• Appearance: Off-white to white crystalline solid
• Density: 1.36 g/cm³
• Vapor Pressure: 0.000185mmHg at 25°C
• CAS DataBase Reference: (4-FLUOROPHENYLTHIO)ACETIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: (4-FLUOROPHENYLTHIO)ACETIC ACID(332-51-4)
• EPA Substance Registry System: (4-FLUOROPHENYLTHIO)ACETIC ACID(332-51-4)

Safety Data

• Hazard Codes: C,Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• HazardClass: CORROSIVE
• Hazardous Substances Data: 332-51-4(Hazardous Substances Data)

Usage

General Description

(4-Fluorophenylthio)acetic acid is a chemical compound with the molecular formula C8H7FO2S. It is a derivative of acetic acid with a fluorophenylthio group attached to the carbon atom. (4-FLUOROPHENYLTHIO)ACETIC ACID is classified as a carboxylic acid and is often used in organic synthesis and chemical research. It has potential applications in the development of pharmaceuticals and agrochemicals due to its unique chemical properties. However, it is important to handle this compound with caution as it may pose health and environmental risks if not properly managed.

InChI:InChI=1/C8H7FO2S/c9-6-1-3-7(4-2-6)12-5-8(10)11/h1-4H,5H2,(H,10,11)/p-1

Upstream product

• 226396-70-9 (4-fluoro-phenylsulfanyl)-acetic acid methyl ester 
• 78066-05-4 ethyl 2-(p-fluorophenylthiaoxy)acetate 
• 371-40-4 4-fluoroaniline 
• 68-11-1 mercaptoacetic acid 
• 96783-59-4 1-(4-fluorophenyl)-2-(pyrrolidin-1-yl)diazene 
• 79-11-8 chloroacetic acid 
• 371-42-6 4-Fluorothiophenol 

Downstream Products

• 371-15-3 p-fluorothioanisole 
• 383-38-0 p-fluorophenylsulphonylacetic acid 
• 70932-09-1 2-(p-fluorophenylthiaoxy)acetyl chloride 
• 1009372-91-1 N-(4-bromo-butyl)-2-(4-fluoro-benzenesulfonyl)-N-trityloxy-acetamide 
• 1009372-89-7 2-(4-fluoro-phenylsulfanyl)-N-trityloxy-acetamide 
• 1299398-32-5 3-((4-fluorophenyl)thio)quinoline 
• 32065-14-8 ethylenebis(N,N'-5-chlorosalicylideneiminato)oxovanadium(IV) 
• 3996-46-1 p-FC₆H₄SOCH₂COOH 
• 252874-22-9 N,N'-bis(5-methylsalicylidene)ethylenediaminatooxovanadium(IV) 
• 36913-44-7 N,N'-bis(salicylidene)ethylenediaminatooxovanadium(IV) 
• 658-14-0 4-fluorophenyl methyl sulfoxide 
• 455-15-2 1-(methylsufonyl)-4-fluorobenzene 
• 1224199-53-4 N-cyclohexyl-N-ethyl-(4-fluorophenylthio)acetic acid amide 
• 1092945-80-6 N-[2-(7-fluoro-2,4-dimethyl-1H-indol-3-yl)ethyl]-2-(4-fluorophenylthio)acetamide 

Relevant articles and documents

RETRACTED ARTICLE: Design, synthesis, and biological evaluation of heterotetracyclic quinolinone derivatives as anticancer agents targeting topoisomerases

A series of thiochromeno[2,3-c]quinolin-12-one derivatives with various substitutions were synthesized and evaluated as topoisomerase (Topo) inhibitors. Six (8, 10, 12, 14, 19, and 26) of 23 compounds showed strong inhibitory activities against Topo-media

FMS-LIKE TYROSINE KINASE INHIBITORS

The present invention relates to Fms-like tyrosine kinase (FLT3) inhibitors. The present invention provides novel 4-quinolinone derivatives used as FLT3 inhibitors and for treatment and/or prevention of tumors.

Synthesis of thioether andrographolide derivatives and their inhibitory effect against cancer cells

A series of novel thioether andrographolide derivatives were synthesized by incorporating various aromatic (or heteroaromatic) substituents into C-12 or 14-OH. A total of 38 andrographolide derivatives were prepared and evaluated for their in vitro inhibi