3832-97-1

Upstream product

• 26832-96-2 diethyl 2-(4-fluoroanilino)methylenemalonate 
• 371-40-4 4-fluoroaniline 
• 74-96-4 ethyl bromide 
• 71083-00-6 ethyl 6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylate 

Relevant academic research and scientific papers

Compound with carbostyril and beta-lactam structure and synthesis method thereof

The invention provides a compound with a carbostyril and beta-lactam structure and a synthesis method thereof. The molecular structure of the compound is as shown in the specification, and the compound is 6-(1-ethyl-6-fluorin-4-oxo-1,4-dihydro-quinoline-3

Bacterial patterning controlled by light exposure

Patterning of multiple bacterial strains in one system is achieved by employing a single photo-activated antibiotic. Varying the light-exposure time results in zones with mixed and single populations.

A small-molecule inhibitor of nipah virus envelope protein-mediated membrane fusion

Nipah virus (NiV), a highly pathogenic paramyxovirus, causes respiratory disease in pigs and severe febrile encephalitis in humans with high mortality rates. On the basis of the structural similarity of viral fusion (F) proteins within the family Paramyxoviridae, we designed and tested 18 quinolone derivatives in a NiV and measles virus (MV) envelope protein-based fusion assay beside evaluation of cytotoxicity. We found five compounds successfully inhibiting NiV envelope protein-induced cell fusion. The most active molecules (19 and 20), which also inhibit the syncytium formation induced by infectious NiV and show a low cytotoxicity in Vero cells, represent a promising lead quinolone-type compound structure. Molecular modeling indicated that compound 19 fits well into a particular protein cavity present on the NiV F protein that is important for the fusion process. 2009 American Chemical Society.