383368-74-9

Upstream product

• 124-63-0 methanesulfonyl chloride 
• 383368-73-8 2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(1-ethoxy-ethoxy)-3,6-dihydro-2H-pyran-3-ol 
• 14086-08-9 (R)-2-(2-furyl)-1,2-ethanediol 
• 381164-65-4 (S)-2-(tert-butyldiphenylsilyloxy)-1-(2-furyl)ethyl benzoate 
• 381164-68-7 2-(tert-butyl-diphenyl-silanyloxymethyl)-6-(1-ethoxy-ethoxy)-6H-pyran-3-one 
• 381164-67-6 2-(tert-butyl-diphenyl-silanyloxymethyl)-6-hydroxy-6H-pyran-3-one 
• 381164-66-5 (S)-2-(tert-butyldiphenylsilyloxy)-1-(furan-2-yl)ethanol 
• 381164-73-4 Benzoic acid (S)-1-furan-2-yl-2-hydroxy-ethyl ester 
• 13265-84-4 D-glucal 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 14086-10-3 C₂₀H₁₆O₅ 

Downstream Products

• 381164-69-8 tert-butyl-[6-(1-ethoxy-ethoxy)-3,6-dihydro-2H-pyran-2-ylmethoxy]-diphenyl-silane 
• 64543-31-3 (-)-5R-5-hydroxydodeca-Z,Z-2,6-dienoic acid lactone 

Relevant academic research and scientific papers

Total synthesis and anti-leishmanial activity of R-(-)-argentilactone

Starting from the commercially available D-glucal (2), the naturally occurring α,β-unsaturated δ-lactone argentilactone (1a) has been synthesized. The important step is the configuration inversion at C-6 by the Mitsunobu reaction following the sugar-non-sugar-sugar strategy. The synthetic argentilactone has been tested against Leishmania mexicana for bioactivity.