3335-98-6

Basic information

• Product Name: 1-Phenyloxindole
• Synonyms: 1-PHENYL-1,3-DIHYDRO-2H-INDOL-2-ONE;1-PHENYLOXINDOLE;1-PHENYLINDOLIN-2-ONE;PHENYLOXINDOLE;N-PHENYL-2-INDOLINONE;n-phenyloxindole;Phenyloxindol;1,3-Dihydro-1-phenyl-2H-indol-2-one 98%
• CAS NO: 3335-98-6
• Molecular Formula: C₁₄H₁₁NO
• Molecular Weight: 209.24
• EINECS: 1312995-182-4
• Product Categories: blocks;IndolesOxindoles;Indoline & Oxindole
• Mol File: 3335-98-6.mol
• Article Data: 34

Chemical Properties

• Melting Point: 123-125
• Boiling Point: 443.6 °C at 760 mmHg
• Flash Point: 222.7 °C
• Appearance: /
• Density: 1.228 g/cm³
• Vapor Pressure: 4.56E-08mmHg at 25°C
• Refractive Index: 1.648
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: Practically insoluble in water
• PKA: -3.41±0.20(Predicted)
• Water Solubility: 74.3mg/L at 20℃
• CAS DataBase Reference: 1-Phenyloxindole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Phenyloxindole(3335-98-6)
• EPA Substance Registry System: 1-Phenyloxindole(3335-98-6)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 3335-98-6(Hazardous Substances Data)

Usage

Flammability and Explosibility

Nonflammable

InChI:InChI=1/C14H11NO/c16-14-10-11-6-4-5-9-13(11)15(14)12-7-2-1-3-8-12/h1-9H,10H2

Synthetic route

sodium; (2-phenylamino-phenyl)-acetate → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With trifluoroacetic anhydride Product distribution; Further Variations:; Reagents;	100%
Multi-step reaction with 4 steps 1: 98 percent / dimethylformamide / 4 h / 24 °C 2: 98 percent / Et3N; DMAP / CH2Cl2 / 3.5 h / 20 - 40 °C 3: 95 percent / hydrogen / Pd/C / methanol / 3 h / 30 °C 4: polyphosphoric acid / toluene / 11 h / 110 °C View Scheme

2-diazo-N,N-diphenyl-acetamide (38118-74-0) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With [(S)-(2-phenyl-4-pheox)Ru(CH3CN)4]PF6 In dichloromethane at 20℃; for 0.0166667h; Inert atmosphere; regioselective reaction;	99%

2-chloro-N,N-diphenylacetamide (5428-43-3) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With palladium diacetate; triethylamine; johnphos In toluene at 80℃; for 3h;	95%
With aluminium trichloride at 180 - 190℃; for 0.166667h;	81.5%
With aluminium trichloride at 180 - 190℃; for 1h;	75%

1-phenyl-indole-2,3-dione (723-89-7) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With hydrazine hydrate for 0.25h; Heating;	92%
Stage #1: 1-phenyl-indole-2,3-dione With potassium hydroxide; hydrazine In water; ethylene glycol at 160℃; for 1.5h; Stage #2: With hydrogenchloride In water; ethylene glycol	90%
With hydrazine hydrate In ethanol for 6h; Wolff-Kishner reduction; Heating;	58%

3-(methylthio)-1-phenylindolin-2-one (79388-20-8) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With nickel In ethanol for 2h; Heating;	85%

2-acetoxy-N,N-diphenylacetamide → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With sulfuric acid; tetrabutylammomium bromide In 5,5-dimethyl-1,3-cyclohexadiene at 100℃; for 16h; Solvent; Reagent/catalyst;	84%

2-oxoindole (59-48-3) + iodobenzene (591-50-4) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In 1,4-dioxane for 24h; Reflux;	83%
With copper(l) iodide; potassium carbonate; N,N`-dimethylethylenediamine In acetonitrile Reflux; Inert atmosphere;	82%
With potassium phosphate; copper(l) iodide In dimethyl sulfoxide at 130℃; for 24h; Ullmann Condensation; Inert atmosphere; Glovebox;	41 %Chromat.
With potassium phosphate; copper(l) iodide; 3-azapentane-1,5-diamine In dimethyl sulfoxide at 50℃; for 24h; Reagent/catalyst; Inert atmosphere; Glovebox; Sealed tube;	27 %Chromat.

2-(2-bromophenyl)-N-phenylacetamide (120230-90-2) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With caesium carbonate; XPhos; palladium diacetate In toluene at 100℃; for 0.5h; microwave irradiation;	82%

2-(2-chlorophenyl)-N-phenylacetamide (71512-21-5) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With caesium carbonate; XPhos; palladium diacetate In toluene at 100℃; for 0.5h; microwave irradiation;	80%

methyl (2-nitrophenyl)acetate (30095-98-8) + phenylboronic acid (98-80-6) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With 1,2,2,3,4,4-hexamethylphosphetane 1-oxide; diphenylsilane In m-xylene at 120℃; for 4h; Catalytic behavior; Reagent/catalyst; Solvent; Inert atmosphere; Schlenk technique; Sealed tube;	80%

diphenylamine (122-39-4) + chloroacetyl chloride (79-04-9) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With montmorillonite KSF at 20℃; for 1.08333h; Stolle synthesis; Sonication; Neat (no solvent);	76%

2-bromo-N,N-diphenylacetamide (6335-34-8) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + N,N-diphenylacetamide (519-87-9)

Conditions	Yield
With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) In toluene for 14h; Heating;	A 8% B 75%

2-chloro-N,N-diphenylacetamide (5428-43-3) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + N,N-diphenylacetamide (519-87-9)

Conditions	Yield
With tri-n-butyl-tin hydride; 2,2'-azobis(isobutyronitrile) In toluene for 14h; Heating;	A 11% B 74%

2-[(methoxycarbonyl)phenylamino]benzeneacetic acid (353497-35-5) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 10,11-dihydro-10-oxo-5H-dibenz[b,f]azepine-5-carboxylic acid methyl ester (353497-31-1)

Conditions	Yield
With PPA at 95℃; for 3h;	A n/a B 70%

C18H21NO2 → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
at 120℃; for 60h;	68%

1-phenyl-1H-indole (16096-33-6) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With water; iodine In N,N-dimethyl-formamide for 12h; Reflux;	62%
With 1-fluoro-1,2-phenyliodohydrin-3-(1H)-one In 1,4-dioxane; water at 140℃; for 5h;	61%
With 1-fluoro-1,2-phenyliodohydrin-3-(1H)-one In 1,4-dioxane; water at 140℃; for 5h;	61%

2-oxoindole (59-48-3) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + N-phenyl-1,3-dihydro-3,3-diphenyl-2H-indol-2-one (124145-27-3)

Conditions	Yield
With cesium fluoride In acetonitrile at 20℃; for 6h;	A 45% B 26%
With cesium fluoride In acetonitrile at 75℃; for 6h; Reagent/catalyst;	A 22% B 39%

2-oxoindole (59-48-3) + bromobenzene (108-86-1) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With potassium carbonate; N,N`-dimethylethylenediamine; copper(l) iodide In acetonitrile Heating;	43%

{2-[Phenyl-(2,2,2-trifluoro-acetyl)-amino]-phenyl}-acetic acid (731851-81-3) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 5-trifluoroacetyl-5,11-dihydro-dibenzo[b,f]azepin-10-one (731851-85-7)

Conditions	Yield
With PPA In toluene at 110℃; for 11h;	A n/a B 40%

2-bromo-N,N-diphenylacetamide (6335-34-8) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
Multistep reaction.;	39%
In acetonitrile Cyclization; Dehydrobromination; Irradiation;	26%
Multistep reaction;	24 mg
Multi-step reaction with 2 steps 1: N,N'-ditosylhydrazine; 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere 2: [(S)-(2-phenyl-4-pheox)Ru(CH3CN)4]PF6 / dichloromethane / 0.02 h / 20 °C / Inert atmosphere View Scheme

2-oxoindole (59-48-3) + 2-(trimethylsilyl)phenyl trifluoromethanesulfonate (88284-48-4) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 5,11-diphenyl-5H-dibenzo[b,e]azepin-6(11H)-one + N-phenyl-1,3-dihydro-3,3-diphenyl-2H-indol-2-one (124145-27-3)

Conditions	Yield
With cesium fluoride In acetonitrile at 20℃; for 6h;	A 15% B 8% C 32%

3-hydroxy-1-phenyl-1,4,5,6-tetrahydro-indol-2-one (52480-52-1) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With pyridine hydrochloride at 230℃; for 1h;	12.4%
With pyridine hydrochloride at 230℃; for 1h; Product distribution; other time, temperature;	12.4%

2-chloro-N,N-diphenylacetamide (5428-43-3) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 3-hydroxy-1,1'-diphenyl-1,3,1',3'-tetrahydro-[3,3']biindolyl-2,2'-dione

Conditions	Yield
With aluminium trichloride

1-phenyl-3.3-dichloro-oxindole → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With calcium hypochlorite; water

2-[2-(phenylamino)phenyl]acetic acid (70172-33-7) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With PPA In toluene at 110℃; for 11h; Product distribution; Further Variations:; Reagents; Solvents; Temperatures;

[2-(acetyl-phenyl-amino)-phenyl]-acetic acid (731851-88-0) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 5-acetyl-1,3-dihydro-1-phenyl-2H-indol-2-one

Conditions	Yield
With PPA at 95℃; for 3h; Product distribution;	A n/a B 35 % Chromat.

[2-(benzyl-phenyl-amino)-phenyl]-acetic acid (731851-78-8) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
With PPA In chlorobenzene at 90℃; for 2h; Product distribution;

diphenylamine (122-39-4) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: 42 percent / NEt3 / CH2Cl2 / 16 h / 20 °C View Scheme
Multi-step reaction with 3 steps 1: 98 percent / 2 h / 20 °C 2: 83 percent / AlCl3 / CS2 / 2 h / 20 °C 3: 58 percent / hydrazine hydrate / ethanol / 6 h / Heating View Scheme
Multi-step reaction with 2 steps 1: 97 percent / dimethylformamide / 2 h / 80 °C 2: 75 percent / AlCl3 / 1 h / 180 - 190 °C View Scheme

(N,N-diphenylcarbamoyl) formyl chloride (75385-92-1) → 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6)

Conditions	Yield
Multi-step reaction with 2 steps 1: 83 percent / AlCl3 / CS2 / 2 h / 20 °C 2: 58 percent / hydrazine hydrate / ethanol / 6 h / Heating View Scheme

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) → sodium; (2-phenylamino-phenyl)-acetate

Conditions	Yield
With sodium hydroxide at 100℃; for 6h;	97%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 4-tert-butylphenyltosylate (7598-28-9) → 3-(4-tert-butylphenyl)-1-phenylindolin-2-one

Conditions	Yield
With potassium fluoride; 2-[2-(dicyclohexylphosphino)-phenyl]-1-methyl-1H-indole; palladium diacetate In tert-butyl alcohol at 20 - 120℃; for 18.0833h; Inert atmosphere; Schlenk technique;	97%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + para-thiocresol (106-45-6) → 1-phenyl-3-(p-tolylthio)indolin-2-one

Conditions	Yield
With oxygen; sodium hydroxide In N,N-dimethyl-formamide at 0℃; for 6h; Green chemistry;	97%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + trifluoromethylsulfonic anhydride (358-23-6) → 1-phenyl-1H-indol-2-yl trifluoromethanesulfonate (1373936-46-9)

Conditions	Yield
With 2,4,6-tri-tertbutylpyridine In 1,2-dichloro-ethane at 0 - 20℃; Inert atmosphere;	96%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + ethyl 2,3-butadienoate (14369-81-4) → C26H27NO5

Conditions	Yield
With triphenylphosphine In 5,5-dimethyl-1,3-cyclohexadiene at 50℃; for 24h; Inert atmosphere;	96%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + (SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide → (S)-2-methyl-N-(2,2,2-trifluoro-1-(2-oxo-1-phenylindolin-3-yl)ethyl)propane-2-sulfinamide + (S)-2-methyl-N-((S)-2,2,2-trifluoro-1-((S)-2-oxo-1-phenylindolin-3-yl)ethyl)propane-2-sulfinamide

Conditions	Yield
Stage #1: 1-phenyl-1,3-dihydro-indol-2-one With lithium diisopropyl amide In hexane; dichloromethane at -78℃; for 1h; Inert atmosphere; Stage #2: (SS)-2-methyl-N-(2,2,2-trifluoroethylidene)-propane-2-sulfinamide In hexane; dichloromethane at -78℃; for 5h; Inert atmosphere; Stage #3: With ammonium chloride In hexane; dichloromethane; water at -78℃; Inert atmosphere; diastereoselective reaction;	A n/a B 95%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + chlorobenzene (108-90-7) → 1,3-dihydro-1,3-diphenyl-2H-indol-2-one (23210-25-5)

Conditions	Yield
With copper(II) ferrite; potassium carbonate In 1,4-dioxane at 70℃; for 1.33333h; Reagent/catalyst;	95%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + chlorobenzene (108-90-7) → 1,3-dihydro-1,3-diphenyl-2H-indol-2-one (23210-25-5) + N-phenyl-1,3-dihydro-3,3-diphenyl-2H-indol-2-one (124145-27-3)

Conditions	Yield
With cobalt ferrite; potassium carbonate In 1,4-dioxane at 70℃; for 4h;	A 95% B 8%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + malononitrile (109-77-3) → 2-(2-oxo-1-phenylindolin-3-ylidene)malononitrile (1370462-98-8)

Conditions	Yield
With iron(III) chloride hexahydrate; oxygen In N,N-dimethyl-formamide at 50℃; for 2h; Green chemistry;	95%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + octanol (111-87-5) → C22H27NO (1571113-82-0)

Conditions	Yield
In 1,3,5-trimethyl-benzene at 170℃; for 24h; Inert atmosphere;	94%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 5-chloroindole 2,3-dione (17630-76-1) → (E)-5'-chloro-1-phenyl-[3,3'-biindolinylidene]-2,2'-dione

Conditions	Yield
With zirconium(IV) chloride In ethanol for 10h; Reflux;	94%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + formic acid ethyl ester (109-94-4) → 3-(Hydroxymethylene)-1-phenyloxindole

Conditions	Yield
With potassium tert-butylate In ethanol at 80℃; for 0.0833333h;	93%
In ethanol

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 4-bromobenzenecarbonitrile (623-00-7) → C21H14N2O

Conditions	Yield
With nickel(II) ferrite; potassium carbonate In 1,4-dioxane at 70℃; for 1.66667h; Reagent/catalyst;	93%

ammonium thiocyanate + 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) → 1-phenyl-5-thiocyanato-1,3-dihydro-indol-2-one

Conditions	Yield
With iodine In methanol at 20℃; for 0.416667h;	92%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + benzyl alcohol (100-51-6) → 3-benzyl-1,3-dihydro-1-phenyl-2H-indol-2-one (23226-10-0)

Conditions	Yield
In 1,3,5-trimethyl-benzene at 170℃; for 24h; Inert atmosphere;	92%
With (1,4-dimethyl-5,7-diphenyl-1,2,3,4-tetrahydro-6H-cyclopenta[b]pyrazin-6-one) irontricarbonyl complex3; potassium carbonate; triphenylphosphine In 5,5-dimethyl-1,3-cyclohexadiene at 150℃; for 24h;	75%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + p-Chlorothiophenol (106-54-7) → 3-((4-chlorophenyl)thio)-1-phenylindolin-2-one

Conditions	Yield
With iron(III) chloride; potassium carbonate In dimethyl sulfoxide at 50℃; for 1h; Green chemistry;	92%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + indole-2,3-dione (91-56-5) → (E)-1-phenyl-[3,3'-biindolinylidene]-2,2'-dione

Conditions	Yield
With zirconium(IV) chloride In ethanol Reflux;	91%
With zirconium(IV) chloride In ethanol for 9h; Reflux;	91%
With hydrogenchloride; acetic acid

1-bromo-4-methoxy-benzene (104-92-7) + 1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) → C21H17NO2

Conditions	Yield
With copper(II) ferrite; potassium carbonate In 1,4-dioxane at 70℃; for 2h; Reagent/catalyst;	91%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + para-chloroacetophenone (99-91-2) → C22H17NO2

Conditions	Yield
With nickel(II) ferrite; potassium carbonate In 1,4-dioxane at 70℃; for 1.66667h; Reagent/catalyst;	91%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 1-isopropyl-1H-indole-2,3-dione (10487-31-7) → (E)-1-isopropyl-1'-phenyl-[3,3'-biindolinylidene]-2,2'-dione

Conditions	Yield
With zirconium(IV) chloride In ethanol Reflux;	91%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + anthranilic acid amide (28144-70-9) → 1-phenyl-1'H-spiro[indoline-3,2'-quinazoline]-2,4'(3'H)-dione (1420904-39-7)

Conditions	Yield
With iron(III) chloride; toluene-4-sulfonic acid In N,N-dimethyl-formamide at 80℃; for 3.5h;	91%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 2-aminobenzanilide (4424-17-3) → 1,3'-diphenyl-1'H-spiro[indoline-3,2'-quinazoline]-2,4'(3'H)-dione

Conditions	Yield
With iron(III) chloride; toluene-4-sulfonic acid In N,N-dimethyl-formamide at 80℃; for 1h;	91%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) → 2-[2-(phenylamino)phenyl]acetic acid (70172-33-7)

Conditions	Yield
With sodium hydroxide In ethanol for 4h; Heating;	90%
With sodium hydroxide In ethanol for 4h; Heating;	88%
With sodium hydroxide In ethanol; water for 4h; Heating; Yield given;
Multi-step reaction with 2 steps 1: 97 percent / aq. NaOH / 6 h / 100 °C 2: acid / pH 2 View Scheme

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + 4-picolylchloride hydrochloride (1822-51-1) → linopirdine (105431-72-9)

Conditions	Yield
With potassium fluoride on basic alumina for 0.05h; microwave irradiation;	90%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) → 1-phenyl-indole-2,3-dione (723-89-7)

Conditions	Yield
With oxygen; sodium iodide In tetrahydrofuran at 60℃; for 12h; Schlenk technique; chemoselective reaction;	90%
With tert.-butylhydroperoxide In 1,2-dichloro-ethane at 85℃; for 24h; Schlenk technique;	84%
With tert.-butylnitrite; oxygen In tetrahydrofuran at 50℃; under 760.051 Torr; for 24h; Schlenk technique; Inert atmosphere;	80%
With tert.-butylnitrite In tetrahydrofuran at 25℃; under 1520.1 Torr;	66%

1-phenyl-1,3-dihydro-indol-2-one (3335-98-6) + N-butylisatin (4290-91-9) → (E)-1-butyl-1'-phenyl-[3,3'-biindolylidene]-2,2'-dione

Conditions	Yield
With zirconium(IV) chloride In ethanol for 10h; Reflux;	90%

Upstream product

• 38118-74-0 2-diazo-N,N-diphenyl-acetamide 
• 91-56-5 indole-2,3-dione 
• 591-50-4 iodobenzene 
• 16096-33-6 1-phenyl-1H-indole 
• 59-48-3 2-oxoindole 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 122-39-4 diphenylamine 
• 79-04-9 chloroacetyl chloride 
• 79388-17-3 diphenyl methyl sulfinylacetamide 
• 79388-14-0 N-phenyl-α-(methylthio)acetanilide 
• 731851-92-6 (2-phenylamino-phenyl)-acetic acid benzyl ester 
• 805236-74-2 [2-(methoxycarbonyl-phenyl-amino)-phenyl]-acetic acid methyl ester 
• 39507-06-7 (2-phenylamino-phenyl)-acetic acid methyl ester 
• 62-53-3 aniline 

Downstream Products

• 856337-37-6 3-bromo-1-phenyl-indolin-2-one 
• 122803-89-8 3-(4-diethylamino-phenylimino)-1-phenyl-indolin-2-one 
• 303984-71-6 1-phenyl-indoline-2,3-dione-3-phenylhydrazone 
• 19621-21-7 (Z)-3-benzylidene-1-phenylindolin-2-one 
• 28150-90-5 1-phenyl-indoline-2,3-dione-3-oxime 
• 16096-33-6 1-phenyl-1H-indole 
• 109312-11-0 5-bromo-1-phenyl-indolin-2-one 
• 856337-27-4 3,3-dibromo-1-phenyl-indolin-2-one 
• 856337-85-4 3,3,5,7-tetrabromo-1-phenyl-indolin-2-one 
• 105431-72-9 linopirdine 

Relevant articles and documents

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α-Sulfanyl N-aryl acetamides, attached to resin via the sulfur atom, undergo efficient Pummerer cyclisation upon activation of the sulfur link, to give oxindoles; heterocyclic products can be cleaved from the resin in a traceless manner using samarium(II) iodide.

Synthesis of Oxindole Derivatives via Intramolecular C–H Insertion of Diazoamides Using Ru(II)-Pheox Catalyst

This work presented the efficient intramolecular aromatic C–H insertion of diazoacetamide. The 1a–1o diazo compounds (except for 1k) were converted into their corresponding oxindoles via an intramolecular C–H insertion reaction in the presence of a Ru catalyst. The Ru-Pheox catalyst was shown to be highly efficient in this transformation in terms of the regioselectivity, producing the desired products in excellent yield (99%). The efficiency of the Ru catalyst reached 580 (TON) and 156 min?1 (TOF).

PIII/PV=O Catalyzed Cascade Synthesis of N-Functionalized Azaheterocycles

An organocatalytic method for the modular synthesis of diverse N-aryl and N-alkyl azaheterocycles (indoles, oxindoles, benzimidazoles, and quinoxalinediones) is reported. The method employs a small-ring organophosphorus-based catalyst (1,2,2,3,4,4-hexamethylphosphetane P-oxide) and a hydrosilane reductant to drive the conversion of ortho-functionalized nitroarenes into azaheterocycles through sequential intermolecular reductive C?N cross coupling with boronic acids, followed by intramolecular cyclization. This method enables the rapid construction of azaheterocycles from readily available building blocks, including a regiospecific approach to N-substituted benzimidazoles and quinoxalinediones.

Preparation method for N-phenyl indolone

The invention especially relates to a preparation method for N-phenyl indolone, belonging to the field of organic synthesis. The preparation method for N-phenyl indolone comprises the following steps:subjecting diphenylamine (a compound as shown in a formula II) and chloroacetyl chloride (a compound as shown in a formula III) to a condensation reaction to prepare 2-chloro-N,N-diphenylacetamide (acompound as shown in a formula IV); subjecting 2-chloro-N,N-diphenylacetamide and acetate to an esterification reaction so as to obtain 2-acetoxy-N,N-diphenylacetamide (a compound as shown in a formula V); and subjecting 2-acetoxy-N,N-diphenylacetamide to a ring closure reaction so as to obtain N-phenyl indolone. The preparation method provided by the invention is a clean high-efficiency synthesis method for N-phenyl indolone; in the whole preparation process, high-contamination raw materials are discarded, and reaction temperature is lowered; and the method is friendly to environment and safe and simple to operate, and has great industrial application value.