383670-74-4

Basic information

• Product Name: Difluoro-(4-nitro-phenoxy)-acetic acid ethyl ester
• Synonyms: Difluoro-(4-nitro-phenoxy)-acetic acid ethyl ester
• CAS NO: 383670-74-4
• Molecular Formula: C₁₀H₉F₂NO₅
• Molecular Weight: 261.1789664
• Mol File: 383670-74-4.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Difluoro-(4-nitro-phenoxy)-acetic acid ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Difluoro-(4-nitro-phenoxy)-acetic acid ethyl ester(383670-74-4)
• EPA Substance Registry System: Difluoro-(4-nitro-phenoxy)-acetic acid ethyl ester(383670-74-4)

Safety Data

• Hazardous Substances Data: 383670-74-4(Hazardous Substances Data)

Upstream product

• 100-02-7 4-nitro-phenol 
• 667-27-6 Ethyl bromodifluoroacetate 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 

Downstream Products

• 383670-97-1 ethyl 2-(3-aminophenyloxy)-2,2-difluoroacetate hydrochloride 
• 383670-79-9 ethyl 2-(4-aminophenyloxy)-2,2-difluoroacetate hydrochloride 
• 24210-51-3 2,2-difluoro-2-(4-nitrophenoxy)acetic acid 
• 81932-04-9 1-(bromodifluoromethoxy)-4-nitrobenzene 

Relevant articles and documents

18F-Labeling of Aryl-SCF3, -OCF3 and -OCHF2 with [18F]Fluoride

We report that halogenophilic silver(I) triflate permits halogen exchange (halex) nucleophilic 18F-fluorination of aryl-OCHFCl, -OCF2Br and -SCF2Br precursors under mild conditions. This AgI-mediated process allows for the first time access to a range of 18F-labeled aryl-OCHF2, -OCF3 and -SCF3 derivatives, inclusive of [18F]riluzole. The 18F-labeling of these medicinally important motifs expands the radiochemical space available for PET applications. A halogen exchange (halex) 18F-fluorination process offers access for the first time to 18F-labeled arylOCF3, arylOCHF2 and arylSCF3, three motifs of established medicinal importance in PET radiotracers. The use of silver(I) triflate is critical to permit 18F-labeling under mild conditions.

Benzoxazepinones and their use as squalene synthase inhibitors

There is disclosed a compound represented by the formula [I]: wherein R1 is optionally substituted 1-carboxyethyl group, optionally substituted alkyl-sulfonyl group, optionally substituted (carboxy-cycloalkyl)-alkyl group, -X1-X2-Ar-X3-X4-COOH (wherein X1 and X4 are a bond or alkylene group, X2 and X3 are a bond, -O-, -S-, Ar is divalent aromatic group etc.), R2 is alkyl group optionally substituted with alkanoyloxy group and/or hydroxy group, R3 is alkyl group, and W is halogen atom, etc., or a salt thereof. The compound has the cholesterol lowering activity and the triglyceride lowering activity and is useful for preventing and/or treating hyperlipidemia.