38372-01-9

Upstream product

• 7327-78-8 2-[1-(2-phenylhydrazino)ethyl]phenol 
• 118-93-4 o-hydroxyacetophenone 
• 100-63-0 phenylhydrazine 
• 3033-96-3 4-chloro-2'-hydroxychalcone 
• 43016-14-4 4-chloro-2'-hydroxychalcone dibromide 
• 1426534-12-4 C₂₂H₁₇ClN₂O 
• 1426534-27-1 C₂₂H₁₉ClN₂O 
• 872057-29-9 3-(4-chlorophenyl)-1-(2-methoxyphenyl)-2-propen-1-one 
• 579-74-8 2-Methoxyacetophenone 
• 104-88-1 4-chlorobenzaldehyde 
• 93514-36-4 4'-chloroflavanone 

Downstream Products

• 1426533-84-7 C₂₃H₁₇ClN₂O₃ 
• 1426533-85-8 C₂₅H₂₁ClN₂O₃ 
• 1426533-86-9 C₂₆H₂₃ClN₂O₃ 
• 1426533-87-0 C₂₈H₂₇ClN₂O₃ 

Relevant academic research and scientific papers

One-pot synthesis of 1,3,5-triarylpyrazoles

A series of novel 1,3,5-triarylpyrazoles were synthesized from flavanones, arylhydrazines, and trimethyl phosphate in an one-pot procedure. Facile reaction process, easy after-reaction workshop, and good yields are the distinct characteristics of the developed protocol. The target compounds were characterized by element analysis, infrared ray (IR), 1H NMR spectra, and electrospray ionization-mass spectrometry. The structure of representative compound (C23H20N2O3, Mr = 372.42) was further confirmed by X-ray diffraction. It crystallizes in monoclinic, space group P 21/c, a = 8.9720(5), b = 24.5523(13), c = 8.9687(6) A, α = 90.0000, β = 102.6417(17), γ = 90.0000°, V = 1927.76(20) A3, Z = 4, μ(MoKα) = 0.086, F(000) = 784, Dc = 1.283 g/cm3, the final R = 0.0349 and wR = 0.0844 for 1668 observed reflections (I > 2σ(I)).

Structure-guided design, synthesis and in vitro evaluation of a series of pyrazole-based fatty acid binding protein (FABP) 3 ligands

We designed a series of pyrazole-based carboxylic acids as candidate ligands of heart fatty acid binding protein (H-FABP, or FABP3), based on a comparison of the X-ray crystallographic structures of adipocyte fatty acid binding protein (FABP4)-selective inhibitor (BMS309403) complex and FABP3-elaidic acid complex. Some of the synthesized compounds exhibited dual FABP3/4 ligand activity, and some exhibited selectivity for FABP3.

Synthesis of pyrazole and isoxazole in triethanolamine medium

Reactions of 2′-hydroxy chalcone dibromides 2a-1 with phenyl hydrazine and hydrazine hydrate afford pyrazoles 1a-1 and with hydroxylamine hydrochloride give isoxazoles 5a-f in triethanolamine medium. Similarly reaction of β-diketone 3b-e with phenyl hydra

The preparation of 2-(1-phenyl-5-phenyl or 5-substituted phenyl-1H- pyrazol-3-yl)phenols from trilithiated 2'-hydroxyacetophenone phenylhydrazone and aromatic esters

2'-Hydroxyacetophenone phenylhydrazone was trilithiated with excess lithium diisopropylamide, and the resulting trianion-type intermediate was condensed with a variety of aromatic esters followed by acid cyclization to 2-(1-phenyl-5-phenyl or 5-substitute

SYNTHESIS OF SOME ISOMERIC PYRAZOLES

The syntheses of 3-o-hydroxyphenyl-1,5-diphenylpyrazoles (III) and 1,3-diphenyl-5-o-hydroxyphenylpyrazoles (V) by the oxidation of corresponding pyrazolines (II) with manganese dioxide and by the reaction of phenylhydrazine with 2'-hydroxychalcone dibromi