38372-24-6

Upstream product

• 387-79-1 17-Hydroxypregnenolone 
• 1093959-59-1 3β-hydroxypregn-5-en-20-one-3-acetate 
• 979-02-2 16-dehydropregnenolone acetate 

Downstream Products

• 566-65-4 dihydroprogesterone 
• 24199-63-1 {4-[Bis-(2-chloro-ethyl)-amino]-phenyl}-acetic acid (3S,8S,9S,10R,13S,14S)-17-acetyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl ester 
• 64226-67-1 3α-(1H-uracil-1-yl)-pregn-5-en-20-one 
• 64226-61-5 3α-(3H-uracil-3-yl)-pregn-5-en-20-one 
• 1232-18-4 17-Ethyl-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-cyclopenta[a]phenanthren-3-one 
• 2862-58-0 (S)-17-Ethyl-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 
• 53-43-0 dehydroepiandrosterone 
• 1164-98-3 3β-21-Dihydroxy-5-pregnen-20-one 
• 91414-17-4 3β-hydroxy-20-phenylselenopregna-5,17-diene 
• 57-83-0 progesterone 

Relevant academic research and scientific papers

Proline-promoted dehydroxylation of α-ketols

A new single-step proline-potassium acetate promoted reductive dehydroxylation of α-ketols is reported. We introduce the unexplored reactivity of proline and, for the first time, reveal its ability to function as a reducing agent. The developed metal-free and open-flask operation generally results in good yields. Our protocol allows the challenging selective dehydroxylation of hydroxyketones without affecting other functional groups.

Steroidal androgen receptor inhibitor as well as preparation method and medical application thereof

The invention relates to the field of medicinal chemistry, in particular relates to a steroidal androgen receptor inhibitor as well as a preparation method and medical application thereof, and particularly discloses medicines for treating related diseases of an androgen receptor, for example, cell proliferation dependent on androgen, hirsutism, acnes, androgenetic alopecia and the like. The general structural formula of the compound is as shown in the specification; and group definitions in the general formula are specified in the specification.