38373-44-3 Usage
Uses
Used in Pharmaceutical Industry:
5-Chloro-2-methoxy-pyrimidine is utilized as a building block in the synthesis of various pharmaceuticals. Its unique structure allows it to be incorporated into the development of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, 5-chloro-2-methoxy-pyrimidine serves as a key component in the creation of agrochemicals. Its properties make it suitable for the formulation of pesticides and other agricultural chemicals, enhancing crop protection and yield.
Used in Organic Compound Production:
5-Chloro-2-methoxy-pyrimidine is employed as an intermediate in the synthesis of complex organic compounds. Its versatility in chemical reactions facilitates the production of a wide array of organic molecules for various applications.
Used in Synthesis of Complex Molecules:
As an intermediate, 5-chloro-2-methoxy-pyrimidine plays a crucial role in the synthesis of complex molecules. Its presence in these reactions aids in the construction of intricate molecular structures with specific functions and properties.
Check Digit Verification of cas no
The CAS Registry Mumber 38373-44-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,8,3,7 and 3 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 38373-44:
(7*3)+(6*8)+(5*3)+(4*7)+(3*3)+(2*4)+(1*4)=133
133 % 10 = 3
So 38373-44-3 is a valid CAS Registry Number.
InChI:InChI=1/C5H5ClN2O/c1-9-5-7-2-4(6)3-8-5/h2-3H,1H3
38373-44-3Relevant academic research and scientific papers
Pharmacological Evaluation of Novel Bioisosteres of an Adamantanyl Benzamide P2X7 Receptor Antagonist
Wilkinson, Shane M.,Barron, Melissa L.,O'Brien-Brown, James,Janssen, Bieneke,Stokes, Leanne,Werry, Eryn L.,Chishty, Mansoor,Skarratt, Kristen K.,Ong, Jennifer A.,Hibbs, David E.,Vugts, Danielle J.,Fuller, Stephen,Windhorst, Albert D.,Kassiou, Michael
, p. 2374 - 2380 (2017/11/21)
Adamantanyl benzamide 1 was identified as a potent P2X7R antagonist but failed to progress further due to poor metabolic stability. We describe the synthesis and SAR of a series of bioisosteres of benzamide 1 to explore improvements in the pharmacological properties of this lead. Initial efforts investigated a series of heteroaromatic bioisosteres, which demonstrated improved physicochemical properties but reduced P2X7R antagonism. Installation of bioisosteric fluorine on the adamantane bridgeheads was well tolerated and led to a series of bioisosteres with improved physicochemical properties and metabolic stability. Trifluorinated benzamide 34 demonstrated optimal physicochemical parameters, superior metabolic stability (ten times longer than lead benzamide 1), and an improved physicokinetic profile and proved effective in the presence of several known P2X7R polymorphisms.
