383883-62-3

Upstream product

• 54125-02-9 danishefsky's diene 
• 383883-64-5 (3R,4S)-3-Methoxy-4-{[(E)-4-methoxy-phenylimino]-methyl}-1-p-tolyl-azetidin-2-one 
• 104-94-9 4-methoxy-aniline 
• 383883-66-7 (+)-(3R,4R)-4-formyl-3-methoxy-1-(p-tolyl)-2-azetidinone 

Downstream Products

• 604788-89-8 (3R,4S)-4-[(2R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(4-methoxy-phenyl)-piperidin-2-yl]-3-methoxy-1-p-tolyl-azetidin-2-one 
• 604788-91-2 (3R,4S)-4-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(4-methoxy-phenyl)-piperidin-2-yl]-3-methoxy-1-p-tolyl-azetidin-2-one 
• 604788-94-5 (3R,4S)-4-[(2R,4R)-4-(tert-Butyl-dimethyl-silanyloxy)-piperidin-2-yl]-3-methoxy-1-p-tolyl-azetidin-2-one 
• 604788-93-4 (3R,4S)-4-[(2R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-piperidin-2-yl]-3-methoxy-1-p-tolyl-azetidin-2-one 
• 604788-85-4 (3R,4S)-4-[(2R,4S)-4-Hydroxy-1-(4-methoxy-phenyl)-piperidin-2-yl]-3-methoxy-1-p-tolyl-azetidin-2-one 
• 604788-87-6 (3R,4S)-4-[(2R,4R)-4-Hydroxy-1-(4-methoxy-phenyl)-piperidin-2-yl]-3-methoxy-1-p-tolyl-azetidin-2-one 
• 604789-04-0 (1S,2R,7R,8aR)-7-(tert-Butyl-dimethyl-silanyloxy)-2-methoxy-1-p-tolylamino-hexahydro-indolizin-3-one 
• 604788-83-2 (R)-2-((2S,3R)-3-Methoxy-4-oxo-1-p-tolyl-azetidin-2-yl)-1-(4-methoxy-phenyl)-piperidin-4-one 

Relevant academic research and scientific papers

Useful dual Diels-Alder behavior of 2-azetidinone-tethered aryl imines as azadienophiles or azadienes: A β-lactam-based stereocontrolled access to optically pure highly functionalized indolizidine systems

Imines derived from 4-oxoazetidine-2-carbaldehydes have been found to be versatile Diels - Alder reagents in that they exhibit two reactivity patterns. 2-Azetidinone-tethered imines undergo diastereoselective reaction with Danishefsky's diene in the prese

Dual behavior of 2-azetidinone-tethered arylimines as azadienophiles or azadienes. Application to the asymmetric synthesis of indolizidine-type systems

The first methodology to prepare indolizidine systems directly from β-lactams has been developed. This process involves the amide bond cleavage of the β-lactam ring in the aza Diels-Alder cycloadducts with concomitant cyclization. Indolizidinone precursor