383897-60-7

Upstream product

• 54-42-2 5-Iodo-2'-deoxyuridine 
• 74-99-7 prop-1-yne 
• 84558-94-1 5-(1-propynyl)-2'-deoxyuridine 

Downstream Products

• 382137-74-8 3-(β-D-2-deoxyribofuranosyl)-3,7-dihydro-6-methyl-2H-pyrrolo[2,3-d]pyrimidin-2-one 
• 644962-78-7 3-{5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-methyl-3H-furo[2,3-d]pyrimidin-2-one 
• 644962-87-8 3-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-tetrahydro-furan-2-yl}-6-methyl-3,7-dihydro-pyrrolo[2,3-d]pyrimidin-2-one 
• 644962-92-5 Diisopropyl-phosphoramidous acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(6-methyl-2-oxo-2,7-dihydro-pyrrolo[2,3-d]pyrimidin-3-yl)-tetrahydro-furan-3-yl ester 2-cyano-ethyl ester 

Relevant academic research and scientific papers

Synthesis and enzymatic incorporation of a novel, bicyclic pyrimidine nucleoside: A thymidine mimic

Nucleophilic ring-opening and rearrangement reaction of a furanopyrimidine nucleoside with anhydrous hydrazine provided a novel, 6,6-bicyclic pyrimidopyridazin-7-one nucleoside (dH, 4), whose structure was confirmed by X-ray crystallography. This novel nucleoside was converted to its 5′-triphosphate (dHTP) for studies with DNA polymerases and incorporated into a template by using standard phosphoramidite chemistry. In the template, dH directed the incorporation of dATP and to a lesser extent dGTP into the transcript and dHTP was efficiently incorporated at the 3′-end of a primer opposite dA using both exonuclease free Klenow fragment (KF exo-) and Taq DNA polymerases and extended with natural dNTPs.

Pyrrolo-dC and pyrrolo-C: Fluorescent analogs of cytidine and 2′-deoxycytidine for the study of oligonucleotides

Pyrrolo-dC (1a, 6-methyl-3-(2-deoxy-β-D-ribofuranosyl)-3H-pyrrolo[2,3- d]pyrimidin-2-one) and its cyanoethyl phosphoramidite 2a were synthesized. The latter was incorporated into oligodeoxyribonucleotides by standard automated synthesis techniques, where

Synthesis and some biochemical properties of a novel 5,6,7,8-tetrahydropyrimido[4,5-c]pyridazine nucleoside

A novel nucleoside analogue is described based on the pyridazine ring system. The nucleoside was successfully incorporated into DNA via both its phosphoramidite and 5′-triphosphate derivatives. Enzymatically, the analogue behaves essentially as thymidine: