38399-64-3Relevant academic research and scientific papers
Observations on the nature of the tethering chain in the synthesis of biaryls and heterobiaryls via intramolecular free radical ipso substitution reactions
Da Mata, Maria Lucilia E.N.,Motherwell, William B.,Ujjainwalla, Feroze
, p. 141 - 144 (1997)
A study of benzylic sulfonates and their corresponding N-methylsulphonamide derivatives as substrates in potential free radical [1,6] ipso substitution reactions reveals a preference for the alternative [1,7] addition mode. Empirical guidelines for biaryl
Synthesis of biaryls via intramolecular free radical ipso-substitution reactions
Ujjainwalla, Feroze,Da Mata, Maria Lucília E.N.,Pennell, Andrew M.K.,Escolano, Carmen,Motherwell, William B.,Vázquez, Santiago
, p. 6701 - 6719 (2015/08/24)
A variety of functionalised biaryls and heterobiaryls are prepared by intramolecular free radical [1,5]-ipso-substitution using sulfonamide and sulfonate derived tethering chains. The overall efficiency of the process is determined by appropriately positioned substituents on the aromatic acceptor ring. The extension of the process to benzylic sulfonates and their corresponding N-methylsulfonamide alternatives as substrates in potential [1,6]-ipso-substitution reactions leads mainly to the alternative [1,7] addition products.
