384-37-2

Basic information

• Product Name: 1-nitro-2-(trifluoromethylsulfonyl)benzene
• Synonyms: 1-nitro-2-(trifluoromethylsulfonyl)benzene
• CAS NO: 384-37-2
• Molecular Weight: 255.174
• Mol File: 384-37-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-nitro-2-(trifluoromethylsulfonyl)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-nitro-2-(trifluoromethylsulfonyl)benzene(384-37-2)
• EPA Substance Registry System: 1-nitro-2-(trifluoromethylsulfonyl)benzene(384-37-2)

Safety Data

• Hazardous Substances Data: 384-37-2(Hazardous Substances Data)

Usage

Type of compound

Nitroaromatic compound

Groups attached to benzene ring

Nitro group and trifluoromethylsulfonyl group

Usage

Building block in organic synthesis, production of pharmaceuticals and agrochemicals

Physical form

White to pale yellow crystalline solid

Health hazards

Irritant to skin, eyes, and respiratory system

Precautions

Handle with care and in a well-ventilated area

Upstream product

• 2926-29-6 Langlois reagent 
• 365-33-3 2-nitrobenzenediazonium tetrafluoroborate 
• 88-74-4 2-nitro-aniline 
• 1948-95-4 <4-Carboxy-2-nitro-phenyl>-trifluormethyl-sulfon 
• 330-17-6 4-(trifluoromethylthio)benzoic acid 
• 17128-26-6 Trifluormethyl-<4-carboxy-2-nitro-phenyl>-sulfoxid 
• 22351-78-6 N-(2-trifluoromethanesulfonyl-phenyl)-phthalimide 
• 456-56-4 phenyl trifluoromethylsulfide 
• 426-58-4 (trifluoromethylsulfonyl)benzene 
• 17095-18-0 2-((trifluoromethyl)sulfonyl)aniline 
• 17095-16-8 Trifluor-(4-amino-2-nitro-phenyl)-sulfon 
• 1644-87-7 1-nitro-2-[(trifluoromethyl)thio]benzene 

Downstream Products

• 3771-34-4 4-Dimethylamino-2'-trifluormethansulfonyl-azobenzol 
• 17128-17-5 4-Dimethylamino-2'-trifluormethansulfonyl-azobenzol 
• 17095-18-0 2-((trifluoromethyl)sulfonyl)aniline 
• 2358-41-0 1-fluoro-2-[(trifluoromethyl)sulfonyl]benzene 
• 32858-96-1 2-Hydroxyphenyltrifluoromethylsulphone 
• 88-75-5 2-hydroxynitrobenzene 

Relevant articles and documents

Method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide

The invention provides a method for producing 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. 2-nitroaniline is used as an initial raw material, is subjected to diazotization reaction, trifluoromethyl sulfonation reaction, fluoronation, chlorosulfonation reaction, and is reacted with ammonium hydroxide to finally produce the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide. Comparedwith reported synthesis methods, the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has the advantages that the reaction yield of the synthesis route is high, used reaction agents are economic and easy to obtain, reaction conditions are mild and controllable, and in a reaction process, column chromatography and purification are not needed, so that the method for producing the 4-fluoro-3-(trifluoromethylsulfonyl)benzenesulfonamide has wide commercial application prospects.

Copper-Promoted Trifluoromethanesulfonylation and Trifluoromethylation of Arenediazonium Tetrafluoroborates with NaSO2CF3

A tunable chemoselective trifluoromethanesulfonylation and trifluoromethylation of arenediazonium tetrafluoroborates with Langlois' reagent (NaSO2CF3) was developed. The Cu2O-catalyzed reaction in DMSO gave aryl trifluoromethanesulfones as the major products. On the other hand, the trifluoromethylated arenes were produced in the presence of oxidant tert-butyl hydroperoxide, CuBF4(MeCN)4, and 2,2′;6′,2 terpyridine (tpy). Both of these transformations proceed under mild conditions and tolerate functional groups.

An efficient synthesis of ABT-263, a novel inhibitor of antiapoptotic Bcl-2 proteins

ABT-263, a newly developed Bcl-2 inhibitor, was efficiently synthesized. The key intermediates 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-enyl] methyl}piperazin-1-yl)benzoic acid and 4-fluoro-3-[(trifluoromethyl)sulfonyl] benzenesulfonamide were eff